Antinociceptive effects of matrine on neuropathic pain induced by chronic constriction injury

Wang, Haiyan; Li, Yuxiang; Linglu, Dun; Xu, Tan; Hao, Yinju; Liu, Hongyan; Ma, Lin; Jiang, Yibin; Wang, Yanrong; Yu, Jian‐Qiang

doi:10.3109/13880209.2013.767363

Cited by 37 publications

(17 citation statements)

References 30 publications

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“…Furthermore, the growth of MCF-7 breast cancer cells was also inhibited by matrine via the miR-21/PTEN/Akt pathway (8). Additionally, matrine exhibited antinociceptive effects on neuropathic pain induced by chronic constriction injury in mice (9). Matrine was also effective in preventing the conversion of high-fructose diet-induced hepatic steatosis into non-alcoholic steatohepatitis in rats via regulating Nrf2 (5).…”

Section: Introductionmentioning

confidence: 84%

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3-adrenoreceptor/endothelial nitric oxide synthase pathway

Yang

Wang

et al. 2014

Molecular Medicine Reports

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Abstract. Matrine, an alkaloid isolated from the traditional Chinese medicine Sophora flavescens AIT has exhibited a number of therapeutic effects on cardiovascular and liver diseases. The purpose of the present study was to investigate whether matrine has a protective effect on heart failure in rats. Coronary artery ligation was used to induce a heart failure (CHF) model in rats. Four weeks following the procedure, the rats were treated with different doses of matrine for one month. Histopathological examination demonstrated that matrine treatment alleviated myocardial hypertrophy and cardiac fibrosis in failing hearts. Furthermore, matrine administration also inhibited the increase of plasma aspartate amino transferase, creatine phosphokinase and lactate dehydrogenase levels in CHF rats. The rats with heart failure exhibited a significant reduction in ejection fraction and fractional shortening, as well as an increase in the left ventricular end systolic dimension, and matrine attenuated this decline in heart function. Further investigation demonstrated that matrine treatment also inhibited the upregulation of Bax and increase in the Bcl-2 expression in the failing hearts. Furthermore, the upregulation of β3-adrenoreceptor (AR) and endothelial nitric oxide synthase proteins following heart failure were also attenuated by matrine. In conclusion, matrine had a preventive role in heart failure in rats at least in part by inhibiting myocardial apoptosis and the β3-AR pathway.

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Section: Introductionmentioning

confidence: 84%

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3-adrenoreceptor/endothelial nitric oxide synthase pathway

Yang

Wang

et al. 2014

Molecular Medicine Reports

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“…In a mouse model for squamous cell carcinoma, matrine was administered at a dosage of 250 g/kg with no apparent adverse impact on health (49). Furthermore, it has been reported that matrine could ease the pain of cancer patients receiving chemotherapy, enhance the body's immunity and protect major organs such as the heart, liver and kidney from being damaged by chemicals/drugs during chemotherapy (50)(51)(52), all of which could help improve the quality of life of lung cancer patients receiving chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway

Huang

Zhang

et al. 2014

Oncology Reports

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Abstract. Lung cancer is the leading cause of cancer-related mortality in humans. The prognosis for advanced lung cancer patients is extremely poor. Current standard care is rather ineffective for prolonging patient life while preserving satisfactory quality of life due to adverse side-effects. Matrine extracted from the traditional Chinese herbal plant Sophora flavescens was shown to induce cancer cell death in vitro. The aim of this study was to investigate the effect of matrine on the proliferation and apoptosis of lung cancer cells and the molecular basis of matrine-induced apoptosis. The results showed that matrine inhibited cell proliferation and induced apoptosis in lung cancer A549 and 95D cells in a dose-and time-dependent manner. The apoptotic effects of matrine on lung cancer cells appeared to act via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway and downregulation of the expression of the inhibitor of apoptosis protein (IAP) family proteins. Matrine exerts its cancer-killing effect via promoting apoptosis in lung cancer cells and may be a useful adjuvant therapeutic scheme for treating advanced lung cancer patients.

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“…Matrine (C 15 H 24 N 2 O) is an alkaloid extracted from sophora flavescens Ait ., has been demonstrated to possess a wide range of pharmacological effects including antioxidant 10 , anti-tumor 11 , anticancer 12 , antiinflammatory 13 , and antinociceptive 14 . The chemical structure was shown in Fig.…”

mentioning

confidence: 99%

Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2

Sun

et al. 2016

Sci Rep

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The co-infection of porcine reproductive respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) is quite common in clinical settings and no effective treatment to the co-infection is available. In this study, we established the porcine alveolar macrophages (PAM) cells model co-infected with PRRSV/PCV2 with modification in vitro, and investigated the antiviral activity of Matrine on this cell model and further evaluated the effect of Matrine on virus-induced TLR3,4/NF-κB/TNF-α pathway. The results demonstrated PAM cells inoculated with PRRSV followed by PCV2 2 h later enhanced PRRSV and PCV2 replications. Matrine treatment suppressed both PRRSV and PCV2 infection at 12 h post infection. Furthermore, PRRSV/PCV2 co- infection induced IκBα degradation and phosphorylation as well as the translocation of NF-κB from the cytoplasm to the nucleus indicating that PRRSV/PCV2 co-infection induced NF-κB activation. Matrine treatment significantly down-regulated the expression of TLR3, TLR4 and TNF-α although it, to some extent, suppressed p-IκBα expression, suggesting that TLR3,4/NF-κB/TNF-α pathway play an important role of Matrine in combating PRRSV/PCV2 co-infection. It is concluded that Matrine possesses activity against PRRSV/PCV2 co-infection in vitro and suppression of the TLR3,4/NF-κB/TNF-α pathway as an important underlying molecular mechanism. These findings warrant Matrine to be further explored for its antiviral activity in clinical settings.

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Antinociceptive effects of matrine on neuropathic pain induced by chronic constriction injury

Cited by 37 publications

References 30 publications

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3-adrenoreceptor/endothelial nitric oxide synthase pathway

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3-adrenoreceptor/endothelial nitric oxide synthase pathway

Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway

Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2

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