Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception

In vivoanalgesic and anti-inflammatory activities ofRosmarinus officinalisaqueous extracts, rosmarinic acid and its acetyl ester derivative

“…Some studies suggested that ethanol and aqueous extracts of the aerial parts of R. officinalis display analgesic and antiinflammatory activities (Gonzáles-Trujano et al, 2007;Hosseinzaded & Nourbakhsh, 2003). Previous phytochemicals studies reported the involvement of the triterpenes micromeric acid, ursolic acid and ursolic acid in the antinociceptive effects of ethanol extract of Rosmarinus officinalis (Martínez et al, 2012). In our study, we separated the aerial parts of R. officinalis into stems and leaves and tested them separately; the aqueous extracts of these separated parts did not have analgesic activity.…”

“…Recently, Ono et al (2004) reported this compound could be a therapeutic agent to treat Alzheimer's disease. Previous phytochemical studies reported the involvement of three triterpenes in the antinociceptive effect of ethanol extracts of Rosmarinus officinalis (Martínez et al, 2012). In this work we used in vivo models to evaluate the analgesic and anti-inflammatory activities of two aqueous extracts of R. officinalis and of its constituent RA.…”

The Influence of Rosemary Essential Oil Applied Per Os on the Pharmacodynamic and Pharmacokinetic Properties of Paracetamol

“…The observed analgesic effect of REO in hot plate test in our study indicates its central mechanism of analgesia, since both paw licking and jumping are supraspinally integrated responses [24]. Serotonergic and opioid endogenous systems were suggested to be involved in the mechanism of action as an antinociceptive of the essential oil isolated from rosemary [25]. Furthermore, the GABAergic system may be another possible route involved in the pharmacological activity of rosemary [21].…”

Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets

“…Rosemary, especially the leaf extract, is one of the most popular herbs, traditionally consumed as a culinary spice to adjust food flavor, and is widely used in the food and cosmetic industries as a natural antioxidant agent due to its inherently high antioxidant activity. Moreover, this plant has been used for centuries in folk medicine, and a wide variety of pharmacological activities have been attributed, such as hepatoprotective [84], antibacterial [85], anti-atherogenic [86], antidiabetic [87], antinociceptive [88][89], anti-inflammatory [89][90][91], anti-tumor [92,93] and antioxidant [94,95] activities. In addition, rosemary extracts and their isolated components have been shown to exert an antiproliferative effect on breast, liver, prostate, lung and colon cancer cells [96][97][98][99][100].…”