Antinociceptive effectiveness of Tithonia tubaeformis in a vincristine model of chemotherapy-induced painful neuropathy in mice

Nawaz, Noor Ul Ain; Saeed, Muhammad; Rauf, Khalid; Usman, Muhammad; Arif, Muhammad; Ullah, Zaki; Raziq, Naila

doi:10.1016/j.biopha.2018.04.115

Cited by 18 publications

(15 citation statements)

References 70 publications

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“…Our result were coherent with the results from the studies of Kuai et al and Deng et al that postulated that CISP induced thermal and mechanical hyperalgesia (Kuai et al 2020;Deng et al 2012). Moreover, Nawaz et al portrayed that CISP and vincristine decreased the reaction time in models of heat hyperalgesia (Nawaz et al 2018).…”

Section: Discussionsupporting

confidence: 92%

“…The second phase (inflammatory phase) which last between 15 and 30 min after the administration of formalin is associated with the onset of inflammatory reactions which is largely mediated by central nociceptive neurons sensitisation involving the recruitment of cytokines, chemokines and prostaglandins (Martinez et al 2016). The acetic acid writings model is associated with the existence of peritoneum visceral pain involving a complex interplay involving proinflammatory cytokines, prostaglandins, sympathomimetic amines and eicosanoids via the activation of mast cells and peritoneal macrophages (Nawaz et al 2018;Martinez et al 2016). Administration of acetic acid provokes contraction of the abdominal cavity, dorsal abdominal muscles twisting as well as the whole body movement (Le Bars et al 2001;Nawaz et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The acetic acid writings model is associated with the existence of peritoneum visceral pain involving a complex interplay involving proinflammatory cytokines, prostaglandins, sympathomimetic amines and eicosanoids via the activation of mast cells and peritoneal macrophages (Nawaz et al 2018;Martinez et al 2016). Administration of acetic acid provokes contraction of the abdominal cavity, dorsal abdominal muscles twisting as well as the whole body movement (Le Bars et al 2001;Nawaz et al 2018). The data obtained from the acetic acid writhing test demonstrated that TTE displayed peripheral antinociceptive effects…”

Section: Discussionmentioning

confidence: 99%

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Antiallodynic and anti-hyperalgesia effects ofTiliacora triandraagainst cisplatin-induced peripheral neuropathy

Liu

Wen

et al. 2021

All Life

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Cisplatin (CISP) is one of the most commonly used drug for treating various cancers and solid tumours, however, its usage has been heavy restricted due to its deleterious side effects including peripheral neuropathy. Therefore, this study describes the anti-hyperalgesia and anti-allodynia effects of Tiliacora triandra (TTE) in CISP induced peripheral neuropathy. Peripheral neuropathy was established in rats by intraperitoneal injection of 2.5 mg/kg of CISP once a week for 4 weeks and the rats were concurrently treated with TTE (250 and 500 mg/kg, po) daily for 5 weeks. After the treatment, thermal hyperalgesia, motor coordination (rotarod test), mechanical allodynia, acetic acid writhing and formalin tests were evaluated. The rats were sacrificed and blood samples were collected for estimation of haematological parameters. TTE significantly restored motor coordination deficits induced by CISP and TTE-treated rats showed marked improvement in thermal/chemical hyperalgesia and mechanical allodynia. Additionally, treatment with TTE also increased haematological parameters including haemoglobin, platelet count, WBC and RBC compared to CISP-treated group. These findings demonstrated that TTE effectively ameliorated CISP induced peripheral neuropathic pain in a cisplatin paradigm.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Antiallodynic and anti-hyperalgesia effects ofTiliacora triandraagainst cisplatin-induced peripheral neuropathy

Liu

Wen

et al. 2021

All Life

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“…A Mexican medicinal plant Tithonia tubaeformis is used for the treatment of rheumatism and stomachache. Its hydromethanolic extract is effective in attenuating vincristine-induced allodynia and thermal hyperalgesia in mice, relieving chemotherapy-induced peripheral neuropathy (Nawaz et al, 2018 ). Hypericum perforatum (St. John's Wort) is used for centuries as a natural remedy for the treatment of a variety of disorders including depression (Asgary et al, 2012 ; Abtahi Froushani et al, 2015 ).…”

Section: Need To Clarify the Prevention Of Neurotoxicitymentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

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“…Furthermore, its analgesic effect was demonstrated with the administration of an oral increased dose of a hydroalcoholic extract (100 and 200 mg/kg) in the acid acetic-induced writhing and tail immersion tests. Furthermore, the same doses of hydroalcoholic extract reduced tactile allodynia and thermal hyperalgesia in vincristine-induced neuropathy [ 206 ]. Mice treated with 2000 mg/kg of methanolic extract from T. tubaeformis did not show behavioral changes, cyanosis, or other signs.…”

Section: Preclinical Studies Of Mexican Medicinal Plants Used In Inflammatory and Neuropathic Pain Treatmentmentioning

confidence: 99%

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Quiñonez-Bastidas

Navarrete

2021

Plants

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Despite the availability of many anti-pain drugs, in the form of NSAIDs, steroids, gabapentinoids, opioids, and antidepressants, in this study we address the natural compounds belonging to the group of Mexican medicinal plants or “Mexican folk medicine”, used for pain management in Mexico. Our interest in this subject is due to the growing idea that “natural is harmless” and to the large number of side effects exhibited in pharmacotherapy. The objective of this review was to document the scientific evidence about Mexican medicinal plants and their derivatives used for inflammatory and neuropathic pain treatment, as well as the mechanisms of action implicated in their antinociceptive effects, their possible adverse effects, and the main pharmacological aspects of each plant or compound. Our data review suggested that most studies on Mexican medicinal plants have used inflammatory experimental models for testing. The anti-pain properties exerted by medicinal plants lack adverse effects, and their toxicological assays report that they are safe to consume; therefore, more studies should be performed on preclinical neuropathic pain models. Moreover, there is no convincing evidence about the possible mechanisms of action involved in the anti-pain properties exerted by Mexican plants. Therefore, the isolation and pharmacological characterization of these plant derivatives’ compounds will be important in the design of future preclinical studies.

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Antinociceptive effectiveness of Tithonia tubaeformis in a vincristine model of chemotherapy-induced painful neuropathy in mice

Cited by 18 publications

References 70 publications

Antiallodynic and anti-hyperalgesia effects ofTiliacora triandraagainst cisplatin-induced peripheral neuropathy

Antiallodynic and anti-hyperalgesia effects ofTiliacora triandraagainst cisplatin-induced peripheral neuropathy

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

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