Antinociceptive Effect of Volatile Oils from Ocimum basilicum Flowers on Adult Zebrafish

Batista, Francisco Lucas Alves; Araújo, José Ismael Feitosa de; Araújo, Sandra Maria Barbosa de; Sousa, Daniela Braga de; Sobrinho, Francisco Bastos C.; Bezerra, Franciglauber Silva; Silva, Maria Gabriely de Lima; Oliveira, Maria Rayane Correia de; Costa, Roger Henrique Sousa da; Rodrigues, Lindaiane Bezerra; Magalhães, Francisco Ernani Alves; Coutinho, Henrique Douglas Melo; Menezes, Irwin Rose Alencar de

doi:10.1007/s43450-021-00154-5

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The sensitivity caused by this oil can be associated to its major compound eugenol 65 . On the other hand, similar results were found with Ocimum basilicum essential oil showed no alteration in locomotor activity or death in adult zebrafish, even after 96 h of analysis, corroborating the results obtained in this study 66 . The zebrafish has been a wellaccepted model in vitro toxicological tests performed in laboratory 67 .…”

Section: Discussionsupporting

confidence: 91%

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Camilo

Leite

Mendes

et al. 2022

Sci Rep

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Lippia sidoides Cham. (Verbenaceae) is a species often mentioned in traditional medicine due to the medicinal properties attributed to its leaves, which include antibacterial, antifungal, acaricidal and antioxidant. Several of these actions have been scientifically proven, according to reports in the literature; however, little is known about toxicological aspects of this plant. This work included studies to determine the chemical composition and toxicity tests, using several methods aiming to evaluate the safety for use of the aqueous extract of L. sidoides leaves, in addition, the anxiolytic effect on adult zebrafish was investigated, thus contributing to the pharmacological knowledge and traditional medicine concerning the specie under study. The chemical profile was determined by liquid chromatography coupled to mass spectrometry-HPLC/MS with electrospray ionization. Toxicity was evaluated by zebrafish, Drosophila melanogaster, blood cells, and Artemia salina models. 12 compounds belonging to the flavonoid class were identified. In the toxicity assays, the observed results showed low toxicity of the aqueous extract in all tests performed. In the analysis with zebrafish, the highest doses of the extract were anxiolytic, neuromodulating the GABAa receptor. The obtained results support the safe use of the aqueous extract of L. sidoides leaves for the development of new drugs and for the use by populations in traditional medicine.

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Section: Discussionsupporting

confidence: 91%

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Camilo

Leite

Mendes

et al. 2022

Sci Rep

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“…During embryonic development, zebrafish will create melanin in their bodies; zebrafish exposed to EOs show a large decrease in this melanin, which might be indicative of an anti-melanogenic effect (Ho et al, 2023;Kim et al, 2023;Yan et al, 2023;Zhou et al, 2020). In addition, the anti-nociceptive effects of EOs on a zebrafish model of chemically induced pain were investigated (Batista et al, 2021;Lima et al, 2020). Moreover, the effects of EOs on anti-osteoporotic, anti-genotoxicity, and promotion of intestinal microbial homeostasis have been investigated in zebrafish models (Hasankhani et al, 2023;Khalil et al, 2011;Stephen, 2019).…”

Section: Zebrafish Models For the Evaluation Of Other Bioactivitiesmentioning

confidence: 99%

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Wang,

Yu,

Ding

et al. 2023

Qual. Assur. Saf. Crops Foods

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Essential oils (EOs) derived from crops, especially aromatic plants, have been well-acknowledged to provide several health benefits for humans. Zebrafish as an unprecedented tool has been widely used as an excellent vertebrate model in labs owing to its many useful characteristics. Its applications for rapidly and economically screening and identifying toxicity, safety, and bioactivity of EOs may serve to meet the rising demand for nutraceuticals, food supplements, and natural cosmetics. In this study, we summarized the research progress of zebrafish models in evaluating EOs. In addition, toxicity, safety, and various bioactivities of EOs were summarized using a wide variety of readily applicable zebrafish models covering antioxidant, anti-inflammatory, angiogenesis inhibition, neuromodulation, anesthesia, anti-melanogenesis, analgesic activities, etc. In conclusion, zebrafish is a valuable animal model for evaluating the bioactivity and safety of EOs, and using such a model may contribute to speeding up the identification of novel EOs with potential health functions and quality assessment, which in turn boosts the recognition of aromatic plants as important industrial crops and encourages a healthier way of life.

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Toxicological effects of aqueous extract of Genipa americana L. leaves on adult zebrafish (Danio rerio): Chemical profile, histopathological effects and lack of genotoxicity

Claro,

Rivero-Wendt,

Miranda-Vilela

et al. 2023

Toxicon

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Antinociceptive Effect of Volatile Oils from Ocimum basilicum Flowers on Adult Zebrafish

Cited by 3 publications

References 34 publications

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Toxicological effects of aqueous extract of Genipa americana L. leaves on adult zebrafish (Danio rerio): Chemical profile, histopathological effects and lack of genotoxicity

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