Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: Evidence for the involvement of apigenin

Pinheiro, Mariana Martins Gomes; Boylan, Fábio; Fernandes, Patrícia Dias

doi:10.1016/j.lfs.2012.06.013

Cited by 50 publications

(34 citation statements)

References 27 publications

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“…For example, luteolin has been found to possess antioxidant [5], anticancer action [6], anti-inflammatory [7], antihepatotoxic action [8], antiallergic, antiosteoporotic [9], antidiabetic [10], and antiplatelet and vasodilatory activity [11]. In addition to antioxidant, anticancer, and anti-inflammatory, apigenin also exhibits antihyperglycemic action [12] and antinociceptive effect [13]. Luteolin and apigenin are natural food additives used extensively in the food and pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Simultaneous Extraction of Luteolin and Apigenin from Tree Peony Pod and Evaluation of Its Antioxidant Activity

Wang

Yang

et al. 2014

The Scientific World Journal

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An efficient microwave-assisted extraction (MAE) technique was employed in simultaneous extraction of luteolin and apigenin from tree peony pod. The MAE procedure was optimized using response surface methodology (RSM) and compared with other conventional extraction techniques of macerate extraction (ME) and heat reflux extraction (HRE). The optimal conditions of MAE were as follows: employing 70% ethanol volume fraction as solvent, soaking time of 4 h, liquid-solid ratio of 10 (mL/g), microwave irradiation power of 265 W, microwave irradiation time of 9.6 min, and 3 extraction cycles. Under the optimal conditions, 151 μg/g luteolin and 104 μg/g apigenin were extracted from the tree peony pod. Compared with ME and HRE, MAE gave the highest extraction efficiency. The antioxidant activities of the extracts obtained by MAE, ME, and HRE were evaluated using a 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) free radical-scavenging assay, a ferric reducing antioxidant power assay (FRAP), and a reducing power assay. Meanwhile, the structural changes of the unprocessed and processed tree peony pod samples were analyzed by scanning electron microscopy.

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Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Simultaneous Extraction of Luteolin and Apigenin from Tree Peony Pod and Evaluation of Its Antioxidant Activity

Wang

Yang

et al. 2014

The Scientific World Journal

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“…Acetic acid causes algesic response which involves the interperitoneal liberation of several mediators such as neurotransmitters and neuromodulators, kinnis, histamine, acetylcholine, substance P and prostaglandins. These mediators increase vascular permeability, reduce the threshold of the nociception and stimulate the nervous terminal of nociceptive fibers (Gorzalczany et al, 2011;Pinheiro et al, 2012). In this model, the extract exhibited a significant and dose dependent reduction in the average number of writhes in mice, compared to control.…”

Section: Discussionmentioning

confidence: 81%

Antinociceptive and antiulcer activities of Pycnanthus angolensis

Sofidiya

Awolesi

2015

Revista Brasileira de Farmacognosia

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a b s t r a c tPycnanthus angolensis (Welw) Warb., Myristicaceae, is used in Nigeria folk medicine to treat complaints such as toothache, headache, sore throat, ulcers and wounds. The aim of the study was to investigate the antinociceptive and antiulcer activities of the stem bark extract of Pycnanthus angolensis. Acute toxicity was conducted with a single oral dose of 5 g/kg. Antinociceptive activity was evaluated in acetic acid-induced writhing, formalin and tail immersion tests in mice while antiulcer activity was evaluated in ethanol and indomethacin-induced models in rats. In acetic acid-induced writhing test, the extract (50, 100 and 150 mg/kg, p.o.), significantly reduced the number of writhes (46.75%, 57.28% and 75.69%) respectively, compared to control. The extract significantly (p < 0.001) reduced the time spent in licking the hind paw at both phases, in formalin test. In tail immersion test, significant antinociceptive effect was only observed with the dose of 150 mg/kg, with peak effect at 90 min (43.38%). There is no significant change in the spontaneous locomotor activity of animals in the open field. The extract prevented the gastric ulceration caused by ethanol and indomethacin treatments compared to control. The results showed that P. angolensis extract possesses antinociceptive and antiulcer activities supporting the traditional use for relieving pain and ulcers.

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“…The antinociceptive effect of A. hierochuntica could be promoted by a group of constituents, which were extracted during preparation of AQAH and CHAH, such as flavonoids, alkaloids and others. The aqueous and alcoholic extracts of A. hierochuntica were reported to contain a number of bioactive constituents including apigenin, luteolin, quercetin and kaempferol [10,11] , which were found to have antinociceptive effect that appeared to be mediated by opioid system in a manner similar to the effects of morphine-like compounds [29,35,36] or by inhibition the secretion of inflammatory cytokines such as IL-1 β and TNF-α [29,37,38] . The antinociceptive effect of A. hierochuntica could be attributed to the single or synergetic action of these constituents or other components.…”

Section: Resultsmentioning

confidence: 99%

Antinociceptive and Antiinflammatory Activities of Anastatica hierochuntica and Possible Mechanism of Action

Alatshan¹,

Qnais²,

Wedyan³

et al. 2018

pharmaceutical-sciences

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Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: Evidence for the involvement of apigenin

Abstract: The results obtained indicated that EE and DF have antinociceptive activity that is mediated, at least in part, by opioid and cholinergic systems. This effect can be attributed to the presence of apigenin, a flavonoid in the dichloromethane fraction.

Cited by 50 publications

References 27 publications

Microwave-Assisted Simultaneous Extraction of Luteolin and Apigenin from Tree Peony Pod and Evaluation of Its Antioxidant Activity

Microwave-Assisted Simultaneous Extraction of Luteolin and Apigenin from Tree Peony Pod and Evaluation of Its Antioxidant Activity

Antinociceptive and antiulcer activities of Pycnanthus angolensis

Antinociceptive and Antiinflammatory Activities of Anastatica hierochuntica and Possible Mechanism of Action

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