Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice

Zhang, Guoxin; Zhu, Chunhao; Ma, Lin; Yang, Jiamei; Du, Juan; Zhang, Wenjin; Sun, Tao; Niu, Junfeng; Yu, Jian‐Qiang

doi:10.1016/j.intimp.2019.105753

Cited by 31 publications

(22 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, pre-injury administration of quercetin showed long term effects on mechanical hypersensitivity, indicating the antinociceptive effects of quercetin in CCI model [136]. CCI-induced mechanical allodynia has been reduced by isoorientin [131], morin [132], puerarin [115], EGCG [133], and genistein [135]. Isoorientin [131] and morin [132] reduced cold allodynia.…”

Section: Sciatic Nerve Chronic Constriction Injury (Cci)mentioning

confidence: 92%

“…Morin restored GSH level and decreased nitrite level in the spinal cord [132] and genistein decreased the levels of ROS and MDA, increased GPx and CAT activities to combat the oxidative stress, as well as normalized nerve-injury-induced inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) [135] in CCI model of neuropathic pain. Another study showed that isoorientin increased the levels of T-AOC, T-SOD, and CAT, and decreased MDA levels in CCI operated mice [131].…”

Section: Effects Of Flavonoids On Sciatic Nerve CCI Modelmentioning

confidence: 94%

“…Furthermore, EGCG and compound 30 but not compound 23 reduced NF-κB protein expression in dorsal horn of spinal cord [134]. The treatment of puerarin, and isoorientin also attenuated CCI-induced pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) [115,131]. Genistein also downregulated mRNA expressions of both IL-1β and IL-6 in sciatic nerve and protein expression of IL-1β in DRG and spinal cord [135].…”

Section: Effects Of Flavonoids On Sciatic Nerve CCI Modelmentioning

confidence: 96%

“…CCI-induced mechanical allodynia has been reduced by isoorientin [131], morin [132], puerarin [115], EGCG [133], and genistein [135]. Isoorientin [131] and morin [132] reduced cold allodynia. Luteolin has been reported to reduce cold and mechanical hyperalgesia, but not thermal hyperalgesia [137].…”

Section: Sciatic Nerve Chronic Constriction Injury (Cci)mentioning

confidence: 96%

“…CCI-induced pain includes several symptoms, including spontaneous (tingling, burning, electric-shock like) pain, dysesthesia, paraesthesia, allodynia, and hyperalgesia [127]. Flavonoids diosmin [128], hesperidin [129], and grape seed proanthocyanidins [130] reduced both thermal and mechanical hyperalgesia, whereas isoorientin [131], morin [132], EGCG [133], epigallocatechin derivate compounds 23 and 30 [134], and genistein [135] reduced only thermal hyperalgesia. Quercetin has been reported to reduce thermal and mechanical hypersensitivities in a superior degree compared to gabapentin and morphine [136].…”

Section: Sciatic Nerve Chronic Constriction Injury (Cci)mentioning

confidence: 99%

See 4 more Smart Citations

In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Basu

2020

Molecules

View full text Add to dashboard Cite

Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects.

show abstract

Section: Sciatic Nerve Chronic Constriction Injury (Cci)mentioning

confidence: 92%

Section: Effects Of Flavonoids On Sciatic Nerve CCI Modelmentioning

confidence: 94%

Section: Effects Of Flavonoids On Sciatic Nerve CCI Modelmentioning

confidence: 96%

Section: Sciatic Nerve Chronic Constriction Injury (Cci)mentioning

confidence: 96%

Section: Sciatic Nerve Chronic Constriction Injury (Cci)mentioning

confidence: 99%

See 3 more Smart Citations

In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Basu

2020

Molecules

View full text Add to dashboard Cite

show abstract

Drug Discovery from Medicinal Plants and Phytochemicals against Neuropathic Pain

Palai

Kesh

Rudrapal

2023

Phytochemical Drug Discovery for Central Nervous System Disorders

View full text Add to dashboard Cite

Transcranial direct current stimulation alleviates nociceptive behavior in male rats with neuropathic pain by regulating oxidative stress and reducing neuroinflammation

Akçay

Samur

Derın

2023

J of Neuroscience Research

View full text Add to dashboard Cite

Transcranial direct curent stimulation (tDCS) and trans‐spinal direct current stimulation (tsDCS) are promising therapies for pain that can alter the excitability of neuronal activity in cerebral cortex. The aim of the study is to investigate the therapeutic effects of direct current stimulation (DCS) over the spinal cord and cerebral cortex on oxidative stress and neuroinflammation in rats with chronic constriction injury (CCI). Male Wistar rats were randomly divided into four experimental groups: Sham, CCI, CCI + tDCS and CCI + tsDCS. The neuropathic pain model was induced by using the CCI model. Rats with neuropathy were treated with cathodal tDCS and tsDCS stimulations consisting of 0.5 mA for 30 min a day for 7 days from day 8 onwards. Locomotor activity was measured by open‐field test and nociceptive behavior was assessed by hot‐plate, tail‐flick and Randall–Selitto tests. Following the behavioral experiments, total oxidant capacity (TOC), total antioxidant capacity (TAC) and proinflammatory cytokine levels were evaluated in spinal cord and cerebral cortex tissues. The CCI model induced significant mechanical and thermal hyperalgesia. Nociceptive behaviors in rats with CCI were reversed by DCS treatment. Higher TOC and lower TAC levels were detected in the spinal cord and cerebral cortex tissues of the CCI rats compared to the control. tsDCS treatment amended oxidant/antioxidant status. Moreover, tsDCS modulated the central levels of Tumor necrosis factor‐α (TNF‐α), interleukin 1‐beta (IL‐1β), IL‐6 and IL‐18. tsDCS stimulation showed better therapeutic effect on neuropathic pain by regulating oxidant/antioxidant levels and reducing neuroinflammation. DCS, especially at spinal level, may be a promising therapeutic strategy that can be used alone or in combination with other effective treatments for alleviating neuropathic pain.

show abstract

Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice

Cited by 31 publications

References 84 publications

In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Drug Discovery from Medicinal Plants and Phytochemicals against Neuropathic Pain

Transcranial direct current stimulation alleviates nociceptive behavior in male rats with neuropathic pain by regulating oxidative stress and reducing neuroinflammation

Contact Info

Product

Resources

About