Antinociceptive effect of certain dihydroxy flavones in mice

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

“…They have been shown to inhibit both inflammatory and neuropathic pain through mechanisms involving the inhibition of cytokine production (e.g., IL-1b) and prostaglandin and inducing NO production and endogenous opioid-dependent mechanisms. These data were demonstrated for quercetin and other flavonoids (e.g., myricitrin, hesperidin, and dihydroxy flavones) in models of overt pain-like behavior, such as acetic acid and phenyl-p-benzoquinone-induced abdominal contortions and in the formalin test, in models of mechanical hyperalgesia induced by carrageenan and in thermal hyperalgesia in streptozotocin-induced diabetes [90][91][92][93][94][95]. Depending on the experimental model, flavonoids inhibited the production of intermediate and directly acting nociceptive mediators in inflammatory pain [93] as well as directly antagonized nociceptor sensitization by activating neuronal mechanisms, including the release of endogenous opioids in streptozotocin-induced diabetic neuropathy [90].…”

Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis

“…The acetic acid-induced abdominal constriction assay is regarded as a very sensitive method that uses minimal noxious stimulus, and even weak analgesics can be detected with this test (Vidyalakshmi et al, 2010). In this model, pain is generated indirectly via endogenous mediators like bradykinin, serotonin, histamine, substance P and prostaglandins, which stimulate peripheral nociceptive neurons that are sensitive to narcotic analgesics and non-steroid anti-inflammatory drugs (NSAIDs) (Collier et al, 1968;Derardt et al, 1980).…”

Anti‐Inflammatory and Antinociceptive Activity of Urera aurantiaca

“…), a non‐selective inhibitor of nitric oxide synthase, 30 min before U. aurantiaca 's extract (10 mg/kg i.p.). Doses and drug administration schedules were selected based on previous reports and on pilot experiments in our laboratory (Abdel‐Salam, ; De Mattos et al ., ; Spindola et al ., ; Vidyalakshmi et al ., ). The nociceptive response was evaluated in the acetic acid‐induced abdominal writhing test.…”