Anti‐Inflammatory and Antinociceptive Activity of <i>Urera aurantiaca</i>

Riedel, Rodrigo; Marrassini, Carla; Anesini, Claudia; Gorzalczany, Susana

doi:10.1002/ptr.5226

Cited by 19 publications

(12 citation statements)

References 30 publications

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“…The latter effect was accomplished by inducing a decrease of NO levels (Marrassini et al ., ). Even though the antiinflammatory effect of the UA has previously been demonstrated in vivo (Riedel et al ., ), this is the first time that the antiinflammatory activity of UA has been demonstrated in macrophages, reinforcing the results obtained in vivo . Also, the PF mimicked the effect of the whole extract.…”

Section: Discussionsupporting

confidence: 87%

“…The UA also caused a significant and dose-dependent inhibitory effect on the increased vascular permeability induced by acetic acid; significant inhibition on nociception induced by acetic acid administered intraperitoneally and orally (ED50: 8.7 mg/kg, i.p. ); and presented antioxidant activity in both 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis 3-ethylbenzothiazoline 6-sulfonic acid tests (Riedel et al, 2015).…”

Section: Introductionmentioning

confidence: 97%

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Modulatory Effect of anUrera AurantiacaExtract on Immune and Tumoral Cells During Inflammation

Marrassini

Anesini

2016

Phytother. Res.

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There is a well known link between inflammation and cancer during initiation, propagation and metastasis. Urera aurantiaca (UA) Wedd. (Urticaceae) is a medicinal plant used in traditional medicine to treat inflammatory processes with proven in vivo antiinflammatory and antinociceptive effects. The effects of a methanolic extract (UA) and a purified fraction (PF) on the proliferation of normal and tumoral lymphocytes under the effect of prostaglandin E (PGE ) and on nitric oxide production by lipopolysaccharide-stimulated macrophages was evaluated. Both UA and PF stimulated normal lymphocytes but, in presence of PGE a modulatory effect was observed. The normal lymphocyte proliferation induced by PGE was driven by pathways involving both PKC and H O . In macrophages, UA and PF did not modify cell viability and abrogated the synthesis of nitric oxide induced by lipopolysaccharide. In tumoral lymphocytes, the UA exerted a biphasic effect: at low concentrations it increased cell proliferation, while at high concentrations, it displayed an antiproliferative effect. UA and PF were capable of reverting the proliferative action of PGE . The tumoral cell proliferation induced by PGE is related to PKC, ERK 1/2 and MAP Kinase P38 pathways. The observed effects could be attributed to polyphenols, flavonoids and tannins. This work demonstrates the modulatory effects of the UA on different cell types during inflammatory conditions, which reinforces its antiinflammatory action. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 97%

Modulatory Effect of anUrera AurantiacaExtract on Immune and Tumoral Cells During Inflammation

Marrassini

Anesini

2016

Phytother. Res.

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“…Some of these beneficial effects have been related to their antioxidant action. Oxidative stress has been recognized as a remarkable feature, which is frequently reported in the signalling cascade of inflammation and there are sufficient evidences suggesting its involvement in pathophysiology and complications of various diseases, including gout [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…When these cells become activated, they aggregate and infiltrate tissues where they undergo a respiratory burst, increasing their oxygen use and production of reactive oxygen species (ROS), cytokines as tumor necrosis fator (TNF- α ), interleukins such as IL-1, IL-6, and IL-8, and other mediators of inflammation. These events can initiate and also perpetuate inflammatory cascades and cause subsequent tissue damage [ 22 , 23 ]. It is known that drugs with anti-inflammatory and antihyperuricemic activities at the same time would be of interest for the treatment of gout [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation

Ferraz-Filha

Ferrari

Araújo

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC analysis identified caffeic acid and chlorogenic acid in AEL. Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice. Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema. In addition, AEL antioxidant activity in vitro was evaluated. AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. AEL showed significant antioxidant activity in all evaluated assays. The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases. We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species.

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“…It is a defense response of body characterized by pain, redness, heat, swelling, and loss of function (Riedel et al, 2014).Inflammation is an innate and adaptive immune systems normal body process that occur as a response to microbial pathogen infection, chemical irritation and tissue injury (Pan et al, 2010 ) .The purpose of inflammation is to eliminate or limit the spread of injurious agent and repairing tissue (Nathan, 2002).The reaction comprises systemic and local responses (Mohamed et al, 2011). There are different components to an inflammatory response such as a complex array of enzyme activation, mediator release, cell migration, tissue breakdown and repair.…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking Studies of Phytochemicals of Allophylus serratus Against Cyclooxygenase-2 Enzyme

Jemal

2019

Preprint

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Allophylus serratus is a medicinal plant used traditionally as anti-inflammatory agent. The main objectives of this study are to identify phytochemical compounds that have anti-inflammatory properties from the leaf extracts of Allophylus serratus and to search for cyclooxygenase-2 (COX-2) enzyme inhibitors through molecular docking. From the GC-MS analysis of leaf extracts of this plant, various phytochemicals were identified. About 10of these phytochemical compounds were analyzed for their drug likeliness based on Lipinski's rule of five and inhibitor property against the cyclooxygenase (COX-2) enzyme, a protein responsible for inflammationThe phytochemical compounds which satisfy the Lipinski's rule such as 2,4a,5,6,7,5,5,(R) and Sulfurous acid, dipentyl ester were subjected to docking experiments using AutoDock Vina. The results from molecular docking study revealed that 1H-Benzocycloheptene, 2,4a,5,6,7,8-hexahydro-3,5,5,9-tetramethyl-, (R)-, Sulfurous acid, dipentyl ester and 1,2-Benzenedicarboxylic acid, bis(2-methylpropyl) ester bind effectively to the active site region of COX-2 with a binding energy of -8.9, -8.4, and -7.9, respectively. The binding energy of the phyto-compounds were compared with the known antiinflammatory drug Diclofenac that inhibit COX-2 enzyme. It was found that the phytochemical compounds from leaf extracts of Allophylus serratus have strong inhibitory effect on COX-2 enzyme and as a result they have potential anti-inflammatory medicinal values. Thus the study puts forth experimental validation for traditional antidote and these phyto-compounds could be further promoted as potential lead molecule.

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Anti‐Inflammatory and Antinociceptive Activity of Urera aurantiaca

Cited by 19 publications

References 30 publications

Modulatory Effect of anUrera AurantiacaExtract on Immune and Tumoral Cells During Inflammation

Modulatory Effect of anUrera AurantiacaExtract on Immune and Tumoral Cells During Inflammation

Effects of the Aqueous Extract from Tabebuia roseoalba and Phenolic Acids on Hyperuricemia and Inflammation

Molecular Docking Studies of Phytochemicals of Allophylus serratus Against Cyclooxygenase-2 Enzyme

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