Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice

Santos, Thiago C.; Marques, Maxsuel S.; Menezes, Igor Alexandre Côrtes de; Dias, Kellyane S.; Silva, Aline B. L.; Mello, Iderjane C.M.; Carvalho, Ana Carla da Silva; Cavalcanti, Sócrates C.H.; Antoniolli, Ângelo Roberto; Marçal, R. M.

doi:10.1016/j.fitote.2007.01.006

Cited by 25 publications

(17 citation statements)

References 22 publications

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“…The samples were fixed in lacto-phenol–cotton blue stain and observed under the microscope at 400 x to examine morphological abnormalities. Samples from control SA plates without adding the essential oil were also stained and their morphological aspects were observed (22). …”

Section: Methodsmentioning

confidence: 99%

“…(Lamiaceae), popularly known in Brazil for “alfazema”, is a fast-growing perennial herb found in dense clumps along roadsides, in over-grazed pastures and around stockyards in the tropics. Its branched, semi-woody stems can reach a height of 2 m, and the plant gives off a characteristic minty smell when crushed (21). Originally native to tropical America, it is now considered a weed worldwide (4).…”

Section: Introductionmentioning

confidence: 99%

“…The leaves are used as an anticancer and antifertility (in females) agent, while their aqueous extract has showed an antinociceptive effect and acute toxicity (21). To date, although few reports (11, 27) have found antibacterial and antifungal properties of H. suaveolens essential oil there has been a lack of studies emphasizing its anti- Aspergillus activity.…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition and antifungal activity of Hyptis suaveolens (L.) poit leaves essential oil against Aspergillus species

Moreira¹,

Lima²,

Wanderley³

et al. 2010

Braz. J. Microbiol.

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This study aimed to identify the constituents of the essential oil from Hyptis suaveolens (L.) leaves using a Gas Chromatograph - Mass Spectrometer and assess its inhibitory effect on some potentially pathogenic Aspergilli (A. flavus, A. parasiticus, A. ochraceus, A. fumigatus and A. niger). Eucaliptol (47.64 %) was the most abundant component in the oil, followed for gama-ellemene (8.15 %), beta-pynene (6.55 %), (+)-3-carene (5.16 %), trans-beta-cariophyllene (4.69 %) and germacrene (4.86 %). The essential oil revealed an interesting anti-Aspergillus property characterized by a Minimum Inhibitory Concentration and Minimum Fungicidal Concentration of 40 and 80 µL/mL, respectively. The oil at 80 and 40 µL/mL strongly inhibited the mycelial growth of A. fumigatus and A. parasiticus along 14 days. In addition, at 10 and 20 µL/mL the oil was able to cause morphological changes in A. flavus as decreased conidiation, leakage of cytoplasm, loss of pigmentation and disrupted cell structure suggesting fungal wall degeneration. These findings showed the interesting anti-Aspergillus property of H. suaveolens leaves essential oil supporting its possible rational use as alternative source of new antifungal compounds to be applied in the aspergillosis treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chemical composition and antifungal activity of Hyptis suaveolens (L.) poit leaves essential oil against Aspergillus species

Moreira¹,

Lima²,

Wanderley³

et al. 2010

Braz. J. Microbiol.

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“…have been shown to have anti-inflammatory (Grassi et al, 2006) and antiplasmodial properties (Chukwujekwu et al, 2005). Essential oils isolated from the genus Hyptis, have also been shown to have analgesic and regenerative properties (Melo et al, 2006;Santos et al, 2007;Menezes et al, 2007;Arrigoni-Blank et al, 2008). According to the wide range of activity of the genus, related to skin diseases, and the lack of references on Hyptis lacustris specifically, this plant should be considered for activity-guided fractionation studies.…”

Section: Leishmaniasismentioning

confidence: 99%

Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts

Valadeau

Pabón

Deharo

et al. 2009

Journal of Ethnopharmacology

125

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“…The experimental models used for assessing the peripheral activity were the formalin-nociception test and the acetic acid-induced writhing test (chemical stimuli), while the hot plate method (thermal stimuli) was used specifically for the central activity. The acetic acid-induced abdominal writhing test is a visceral pain model used for screening of peripheral and central analgesic activity (Panthong et al, 2007;Santos et al, 2007). The injection of 0.7% acetic acid in the peritoneal cavity of mice induced writhing which was considered as a stereotyped behavior in the experimental animals.…”

Section: Resultsmentioning

confidence: 99%

Analgesic activity ofGleditsia triacanthosmethanolic fruit extract and its saponin-containing fraction

Saleh¹,

Kassem

Melek

2015

Pharmaceutical Biology

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Context: Gleditsia triacanthos L. (Leguminosae) pods are used in folk medicine for pain relief as anodyne and narcotic. Objective: The objective of this study is to evaluate analgesic activity of Gleditsia triacanthos methanolic fruit extract (MEGT) and its saponin-containing fraction (SFGT). Materials and methods: Peripheral analgesic activity was assessed using the acetic acid-induced writhing model in mice at doses of 140, 280, and 560 mg/kg and formalin test in rats at 100, 200, and 400 mg/kg doses. Central analgesic activity was evaluated using the hotplate method in rats (100, 200, and 400 mg/kg). Results: In the writhing test, six mice groups treated with MEGT and SFGT found ED 50 values 268.2 and 161.2 mg/kg, respectively, displayed a significant decrease in writhing count compared with the group treated with standard drug indomethacin (14 mg/kg). SFGT (280 and 560 mg/kg) showed 64.94 and 70.78% protection, respectively, which are more than double % protection caused by indomethacin (31.82%). In the formalin test, MEGT and SFGT (ED 50 values 287.6 and 283.4 mg/kg for phase I as well as 295.1 and 290.4 mg/kg for phase II, respectively) at 400 mg/kg showed significant % inhibition in both phase I (18.86 and 52.57%) and phase II (39.36 and 44.29%) with reference to 10 mg/kg indomethacin (56.0 and 32.29%). MEGT and SFGT caused significant delay in responses in hotplate model (ED 50 values 155.4 and 200.6 mg/kg, respectively) compared with that of 10 mg/kg indomethacin at 30, 60, and 120 min. Discussion and conclusion: Central and peripheral analgesic activities induced by Gleditsia triacanthos fruits might account for its uses in folk medicine.

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Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice

Cited by 25 publications

References 22 publications

Chemical composition and antifungal activity of Hyptis suaveolens (L.) poit leaves essential oil against Aspergillus species

Chemical composition and antifungal activity of Hyptis suaveolens (L.) poit leaves essential oil against Aspergillus species

Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts

Analgesic activity ofGleditsia triacanthosmethanolic fruit extract and its saponin-containing fraction

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