Antinociceptive, cytotoxic and antibacterial activities of Cleome viscosa leaves

Abstract

Abstract:The methanol extract of the dried leaves of Cleome viscosa L., Cleomaceae, was investigated for its possible antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral doses of 250 and 500 mg/kg body weight (p<0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (p<0.001). The crude extract produced the most prominent cytotoxic activity against brine shrimp Artemia salina (LC50 28.18 µg/mL and LC90 112.20 µg/mL). The extract of C. viscosa L. exhibited significant in vitro antibacterial activity against Staphylococcus saprophyticus, Shigella sonnie, Salmonella typhi, Vibrio cholera, Streptococcus epidermidis, Shigella flexneri and Staphylococcus aureus with the zones of inhibition ranging from 10.76 to 16.34 mm. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.

Propriedades terapêuticas do gênero cleome, familia cleomaceae

“…A Cleome viscosa é uma integrante da família Cleomaceae que demonstrou ser capaz de inibir diversas cepas bacterianas in vitro através da metodologia da difusão em disco, dentre as cepas testadas estão Shigella sonnie, Staphylococcus aureus e Vibrio cholera. O efeito antibacteriano foi considerado relevante e os halos de inibição variaram de 10,76 a 16,34mm para Cleome viscosa e 28,90 a 44,88 no controle (BOSE et al, 2011). Sua utilização tem sido direcionada a diversos problemas de saúde como é o caso da inflamação, problemas hepáticos, diarreia e febre.…”

Antibacterial, antifungal and antioxidant activity of Cleome coluteoides: An In Vitro Comparative Study between Leaves, Stems, and Flowers

“…12 Phytochemical screening studies of Cleome genus have been found phenolic compounds, alkaloids, terpenoids, flavonoids, Fatty acids, coumarino-lignan, rich source of nutrients, especially vitamins A and C, protein, gallotannins, saponins, iridoid, hexacosanol and kaempferol. 7,[13][14][15][16][17] Therefore, finding natural antibacterial, antifungual and antioxdant agents with similar therapeutic effect could be a promising approach, which is safer and healthier. 18 To date, the chemical composition and…”

Inhibition Activity of Cleome Species Extract on Onion Guest Root

“…This plant possesses Ayurveda medicine such as seed used for anthelmintic, leaves used in wound healing, and fever [9,10]. Moreover, pharmacological of this plant is evaluated as an anesthetic, anti-diarrhea, anti-inflammatory, antimalarial, and antipyretic activities [11][12][13]. Moreover, the phytotoxic activity of C. viscosa showed inhibitory effect on germination and growth in agricultural product [14].…”