Antinociceptive, anti-inflammatory and antipyretic properties ofMelastoma malabathricumleaves aqueous extract in experimental animals

Abstract

The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments.

Gastroprotective Effects of Melastoma malabathricum Aqueous Leaf Extract against Ethanol-Induced Gastric Ulcer Iin Rats

“…Oxidative stress can damage many biological molecules. The M. malabathricum flower extract possesses anti-nociceptive; anti-inflammatory and antipyretic activities and thus the ulcer prevention could be attributed to these properties and supports previous claims on its traditional uses to treat various ailments [4] . M. malabathricum flower extract has been shown to contain anti-oxidant cytotoxic flavonoids which may mediate the protection of gastric mucosa [5] .…”

“…The crude extract of M. malabathricum has been used in the treatment of diarrhoea as an astringent and is also used for postpartum treatment and for haemorrhoids [1] . Some metabolites isolated from the Melastoma plant have also been reported to have antiviral and cytotoxic activity [2] ; anti-helmethic and anti-spasmodic action [3] ,anti-nociceptive, anti-inflammatory and antipyretic properties [4] , anti-oxidant and anti-cancer activity [5] and anti-hypertensive activity [6] . However, there is no data available regarding the anti-ulcerogenic activity of the M. malabathricum L. leaf extract.…”

IDENTIFICATION AND MODE OF ACTION OF ANTIBACTERIAL COMPONENTS FROM <I>MELASTOMA MALABATHRICUM</I> LINN LEAVES

“…Antibacterial activity of M. malabathricum was evaluated against standard and clinical isolates of Gram-positive and Gram-negative pathogenic bacteria by disk diffusion method and minimum inhibitory concentration ( Table 1). Zakaria et al (2011) reported that the methanolic extract of M. malabathricum possesses antimicrobial activity and this activity was ascribed to flavonoids. Flavonoids are the most known group of polyphenolic compounds for their pharmacological properties including antibacterial activity (Dulger and Hacioglu, 2009;Marzouk et al, 2010).…”

“…(Melastomataceae) is one of the most important herbs or shrubs found in Malaysia and known to Malays as "senduduk". The plant has been used in traditional Malay medicine for alleviating diarrhea, leucorrhoea, puerperal infection, dysentery; wound healing, post-partum treatment and haemorrhoids (Sirat et al, 2010;Zakaria et al, 2011).…”

“…Several activities have been reported to M. malabathricum leaves including antiviral activity , antibacterial activity (Sunilson et al, 2008;Zulaikah et al, 2008;Choudhury et al, 2011), antioxidant activity (Sirat et al, 2010) and antinociceptive, anti-inflammatory and antipyretic activity (Zakaria et al, 2006).…”