Antinociceptive, anti-inflammatory and antipyretic effects of ethanol extract of Clerodendron serratum roots in experimental animals

Narayanan, N.; Thirugnanasambantham, P.; Subramanian, Venkataraman; Vijayasekaran, V.; Sukumar, E.

doi:10.1016/s0378-8741(98)00176-7

Cited by 36 publications

(17 citation statements)

References 2 publications

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“…f.) exerts antimicrobial and cytotoxic properties (Sikder et al, 2011). Ethanolic extract of the roots of Clerodendrum serratum L. exhibited antibacterial and anti-inflammatory activities (Narayanan et al, 1999). Studies indicate that Glycyrrhiza glabra L. possesses antibacterial, antioxidant, antimalerial, anti-inflammatory, antiviral, antifungal and immunostimulatory activities (Jatav et al, 2011).…”

Section: Immunostimulating Activity Of Knk Was Not Significantly Redumentioning

confidence: 99%

Preliminary study of the immunostimulating activity of an ayurvedic preparation, Kanakasava, on the splenic cells of BALB/c micein vitro

Sarker¹,

Nahar

Shahriar

et al. 2012

Pharmaceutical Biology

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Section: Immunostimulating Activity Of Knk Was Not Significantly Redumentioning

confidence: 99%

Preliminary study of the immunostimulating activity of an ayurvedic preparation, Kanakasava, on the splenic cells of BALB/c micein vitro

Sarker¹,

Nahar

Shahriar

et al. 2012

Pharmaceutical Biology

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“…It is an excellent antihistaminic and antiallergic agent (Gupta and Gupta 1968;Gupta et al 1967) as well as an immunomodulator (Juvekar et al 2006) and also has antinociceptive and anti-inflammatory properties (Narayanan et al 1999). …”

Section: Introductionmentioning

confidence: 99%

In vitro clonal propagation of Clerodendrum serratum (Linn.) Moon (barangi): a rare and threatened medicinal plant

Sharma

Purshottam

et al. 2008

Acta Physiol Plant

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An in vitro process for rapid clonal propagation of Clerodendrum serratum (Linn.) Moon, a rare and threatened medicinal shrub, has been developed. Nodal stem segments having axillary bud, taken from field-grown plant, showed bud-break within 15 days of culture on modified Murashige and Skoog (MS) (Physiol Plant 15:473-497, 1962) medium supplemented with 0.25 mg/l each of 6-benzylaminopurine and indole-3-acetic acid along with 15 mg/l adenine sulphate (AdS). Regenerated shoots could be further multiplied on the same agarified morphogenetic medium in presence of 0.5 mg/l 2-chloroethyltrimethyl ammonium chloride with increased concentration of AdS, i.e., 30 mg/l. A group of five shoots used as inoculum produced on an average 4.98 new shoots per original shoot after 4 weeks of subculture. Shoots excised from cultures of proliferating shoots were rooted in half-strength MS medium having 1 mg/l indole-3-propionic acid. In vitro rooted shoots-plantlets-grew luxuriantly under field conditions and came to flowering after 10 months of transplantation. The genetic fidelity of in vitro-raised field-grown plants and their mother plant was ascertained by random amplified polymorphic DNA markers. The protocol developed holds good for in vitro cloning of C. serratum.

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“…The genus Clerodendron, is reported to demonstrate biological activities such as antitumorgenic [7,8] , Hypoglycemic, hypolipidemic [5,9] , Hepatoprotective activity against CCl 4 induced liver injury in rats [10,11] , Anti-inflammatory [12][13][14] , free radicalscavenging activity, Anti-diarrhoeal, Antinociceptive and antipyretic effects [15][16][17] . To the best of our knowledge, there is only one scientific report published regarding the phytomedicinal properties of CC by Adeneye et al [6] .…”

Section: Introductionmentioning

confidence: 99%

Serotonergic Properties of the Roots of Clerodendron capitatum

Ibrahim¹,

Wahab²,

Mohamed³

et al. 2008

American J. of Biochemistry and Biotechnology

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Abstract:The aim of this study is to investigate the pharmacological effects of the methanolic extract of Clerodendron capitatum, CC, (family verbenaceae). These investigations were carried out on isolated frog rectus abdominus muscle and rabbit aortic strips and jejunum and non-pregnant rat uterus pretreated with oestradiol. Results showed that CC did not demonstrate any contracting, relaxant or blocking effects on frog rectus abdominus muscle and rat aortic strip preparations. The extract produced a concentration-dependent (p<0.05, t-test, n = 6) decrease of the normal rhythmic contraction of rabbit jejunum, however, this effect was reversed by prior addition of cyproheptadine (non-specific 5-HT antagonist). In addition, CC also produced a stimulant activity on rat uterus which was blocked by cyproheptadine. Future study is recommended to study the specificity of CC to different 5-HT receptors by using different isolated animal tissues and specific 5-HT antagonists.

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Antinociceptive, anti-inflammatory and antipyretic effects of ethanol extract of Clerodendron serratum roots in experimental animals

Cited by 36 publications

References 2 publications

Preliminary study of the immunostimulating activity of an ayurvedic preparation, Kanakasava, on the splenic cells of BALB/c micein vitro

Preliminary study of the immunostimulating activity of an ayurvedic preparation, Kanakasava, on the splenic cells of BALB/c micein vitro

In vitro clonal propagation of Clerodendrum serratum (Linn.) Moon (barangi): a rare and threatened medicinal plant

Serotonergic Properties of the Roots of Clerodendron capitatum

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