Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa

Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

“…In 1D-NMR spectrum (Table 2), the presence of two deshielded aromatic proton signals at δ H 9.42 (1H, d, J = 9.2 Hz, H-5) and δ H 8.28 (1H, s, H-4 ) suggested that 4 was a dimeric molecule formed from the fusion of a phenanthrene unit [23,46,53] and a 9,10-dihydrophenanthrene subunit [28,54]. The 1 H spectrum showed resonances for a pair of ortho-coupled aromatic protons at δ H 9.42 (1H, d, J = 9.2 Hz, H-5) and 7.31 (1H, d, J = 9.2 Hz, H-6), a broad singlet integrated for two aromatic protons at δ H 7.43 (2H, s, H-9, H-10), two meta-coupled aromatic protons at δ H 6.39 (1H, d, J = 2.6 Hz, H-6 ) and 6.42 (d, J = 2.6 Hz, H-8 ) and three isolated aromatic protons at δ H 7.11 (1H, s, H-1), 6.92 (1H, s, H-1 ) and 8.28 (1H, s, H-4 ). Additional signals belonging to three methoxyl groups at δ H 4.01 (3H, s, 3-OCH 3 ), 4.00 (3H, s, 4-OCH 3 ), 3.73 (3H, s, 7 -OCH 3 ) and two methylene groups emerging as a broad singlet at δ H 2.80 (4H, s, H-9 and H-10 ), were also observed.…”

“…The phytochemical and biological investigations of this family has been mainly conducted in relation with their traditional uses and focused on a large number of Asian orchids from the genus Arundina, Bletilla, Dendrobium, Gastrodia and Pleione at the expense of the New World orchids In fact, the first report on a phytochemical study of South American orchids was in the late 1990s and was mainly focused on species in the genus Scaphyglottis [1-3], Maxillaria [4][5][6][7] and Cyrtopodium [8][9][10].…”

Ethnobotany, Pharmacology and Chemistry of Medicinal Orchids from Veracruz

“…Anti-inflammatory, anti-nociceptive [28,29] and relaxing activities [30,31] detected in Scaphyglottis livida, a close related species. Lanostadienol derivative, gigantol, ciclobalanone [29].…”

“…Lanostadienol derivative, gigantol, ciclobalanone [29]. Phenanthrenederivati ve [28,30] and 3, 4-dihydroxi-5,5'-dimet hoxy bibenzyl [30].…”

“…Nevertheless, the proven pharmacological effects in a related species, S. livida, include anti-inflammatory [28], anti-nociceptive [29] and smooth muscle relaxing activity [30,31]. The responsible compounds were a lanostadienol derivative, gigantol, ciclobalanone [29], phenanthrene derivatives [28,30] and 3,4-dihydroxi-5,5'-dimetoxy benzyl [30]. The above activities, confirmed through pharmacological testing, might have an overall positive effect that could be related to the therapeutic application of S.…”