Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz

Moraes, Sabrina Zelice da Cruz de; Shan, Andrea Yu Kwan Villar; Melo, Marlange Almeida Oliveira; Silva, Juliane Pereira da; Passos, Fabíolla Rocha Santos; Graça, Ariel de Souza; Araujo, Brancilene Santos de; Quintans, Jullyana de Souza Siqueira; Júnior, Lucindo José Quintans; Barreto, Emiliano; Brandão, Geraldo Célio; Estevam, Charles dos Santos

doi:10.1016/j.jep.2020.112563

Cited by 15 publications

(10 citation statements)

References 68 publications

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“…In addition, TNF-α and IL-1β contents were assessed in previously centrifuged (770× g for 10 min) samples of lung lavages from animals treated with EEHB and indomethacin (both at 10 mg/kg), using ELISA according to the manufacturer’s protocol (BD-Bioscience Pharmingen, San Diego, CA, USA). Data were expressed as pg/mL [ 58 , 59 ].…”

Section: Methodsmentioning

confidence: 99%

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Almeida

Santos

Carvalho

et al. 2022

IJMS

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The Himatanthus genus presents anti-inflammatory, antioxidant activities, suggesting potential wound-healing properties. This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteatus in a murine model. The extract was obtained under high pressure conditions, incorporated (2%) into the GelMA (GelMA-HB), and physically characterized. The anti-inflammatory activity of the extract was assessed using a carrageenan-induced pleurisy model and the GelMA-HB scarring properties in a wound-healing assay. The extract reduced IL-1β and TNF-α levels (48.5 ± 6.7 and 64.1 ± 4.9 pg/mL) compared to the vehicle (94.4 ± 2.3 pg/mL and 106.3 ± 5.7 pg/mL; p < 0.001). GelMA-HB depicted significantly lower swelling and increased resistance to mechanical compression compared to GelMA (p < 0.05). GelMA-HB accelerated wound closure over the time course of the experiment (p < 0.05) and promoted a significantly greater peak of myofibroblast differentiation (36.1 ± 6.6 cells) and microvascular density (23.1 ± 0.7 microvessels) on day 7 in comparison to GelMA (31.9 ± 5.3 cells and 20.2 ± 0.6 microvessels) and the control (25.8 ± 4.6 cells and 17.5 ± 0.5 microvessels) (p < 0.05). In conclusion, GelMA-HB improved wound healing in rodents, probably by modulating the inflammatory response and myofibroblastic and microvascular differentiation.

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Section: Methodsmentioning

confidence: 99%

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Almeida

Santos

Carvalho

et al. 2022

IJMS

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“…[22] 2). Compound 25 (3,4-di-O-galloylquinic acid) has been identified in several plant species, [23,24] but this is the first report of its occurrence in mushrooms. Interestingly, this compound has several biological activities, and its potential association with tea and cosmetics industrial production has been recently suggested.…”

Section: Resultsmentioning

confidence: 95%

Metabolite Profiling of Pleurotus ostreatus Grown on Sisal Agro‐Industrial Waste Supplemented with Cocoa Almond Tegument and Wheat Bran

Ferraz,

Ribeiro,

Verde

et al. 2023

Chemistry & Biodiversity

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Pleurotus ostreatus is an edible fungus with high nutritional value that uses industrial and agricultural lignocellulosic residues as substrates for growth and reproduction. Understanding their growth metabolic dynamics on agro‐industrial wastes would help to develop economically viable and eco‐friendly biotechnological strategies for food production. Thus, we used UHPLC/MS/MS and GNPS as an innovative approach to investigate the chemical composition of two strains of P. ostreatus, coded as BH (Black Hirataki) and WH (White Hirataki), grown on sisal waste mixture (SW) supplemented with 20 % cocoa almond tegument (CAT) or 20 % of wheat bran (WB). Metabolite dereplication allowed the identification of 53 metabolites, which included glycerophospholipids, fatty acids, monoacylglycerols, steroids, carbohydrates, amino acids, and flavonoids. This is the first report of the identification of these compounds in P. ostreatus, except for the steroid ergosterol. Most of the metabolites described in this work possess potential biological activities, which support the nutraceutical properties of P. ostreatus. Thus, the results of this study provide essential leads to the understanding of white‐rot fungi chemical plasticity aiming at developing alternative biotechnologies strategies for waste recycling.

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“…The high amount of phenolic compounds presented in the sapucaia nut samples, when orally administered, showed anti-inflammatory, neuroprotective and anticancer activity due to the presence of ellagic acid, studies indicate that the presence of phenolic compounds is associated with antinociceptive, antitumor and anti-inflammatory activities due to their antioxidant activity, due to the presence of the phenol group, an ideal structure for sequestration and neutralization of free radicals (Moraes et al, 2020).…”

Section: Anti-inflammatory Actionmentioning

confidence: 99%

“…Polyphenolic compounds, mainly ellagic acid derivatives show antioxidant, neuroprotective, antiviral, antimicrobial, antidiabetic, anti-apoptotic, anti-inflammatory, antinociceptive, and antitumor activity (Moraes et al, 2020). Azevedo (2016) attributes the anti-inflammatory activity of terpenes to the interaction with enzymes in the inflammation cascade such as phospholipase A2 (PLA2), cyclooxygenase (COX) and lipoxygenase (LOX).…”

Section: Anti-inflammatory Actionmentioning

confidence: 99%

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Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz

Cited by 15 publications

References 68 publications

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Metabolite Profiling of Pleurotus ostreatus Grown on Sisal Agro‐Industrial Waste Supplemented with Cocoa Almond Tegument and Wheat Bran

Relevant studies focused on health sciences

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