Antinociceptive activity of Wrightia tinctoria bark

Reddy, Y.S.R.; Venkatesh, Sama; Ravichandran, Thanammal; Murugan, V.; Suresh, B.

doi:10.1016/s0367-326x(02)00126-0

Cited by 16 publications

(10 citation statements)

References 3 publications

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“…The ethyl acetate, acetone and methanol extracts showed significant antinociceptive activity and were comparable with acetylsalicylic acid [101]. In the study of Bigonia et al in 2008, the ethanol (70%) extract of W. tinctoria bark showed significant analgesic activity in Eddy's hot plate reaction and tail flick method.…”

Section: Analgesic and Anti-inflammatory Activitymentioning

confidence: 88%

“…Reddy et al evaluated the antinociceptive activity of petroleum ether, chloroform, ethyl acetate, acetone and methanol extracts of W. tinctoria bark on acetic acidinduced writhing test in mice [101]. The ethyl acetate, acetone and methanol extracts showed significant antinociceptive activity and were comparable with acetylsalicylic acid [101].…”

Section: Analgesic and Anti-inflammatory Activitymentioning

confidence: 99%

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Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

2014

JCLM

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Section: Analgesic and Anti-inflammatory Activitymentioning

confidence: 88%

Section: Analgesic and Anti-inflammatory Activitymentioning

confidence: 99%

Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

2014

JCLM

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“…Studies that pursue promising natural products (to identify contraceptive agents from natural sources lacking potent estrogenic activity) towards a fruitful conclusion for development/ lead generation should continue 17 .…”

Section: Post Coital Interceptive Activitymentioning

confidence: 99%

Wrightia tinctoria (Roxb) R.Br. - An updated Review

S¹,

Divakar²

2014

H.J.D.Med.

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“…Many parts of this tree, native to India and Burma, have been extensively used for addressing psoriasis and jaundice in the Indian system of medicine. 9 While the whole plant displayed antinociceptive activity 10 and was effective against psoriasis and non-specific dermatitis, 11 the seeds find use as astringent, carminative, depurative and febrifuge. 12 The leaves of W. tinctoria have immunomodulatory, 13 anti-inflammatory and diuretic activities 14 apart from eliciting good effect against hepatitis C virus.…”

Section: Introductionmentioning

confidence: 99%

Alcoholic Extract of Wrightia tinctoria leaves and Isolates there of afford DNA Protection in Post Irradiated Sprague Dawley Rats

Sathianarayanan¹,

Jose²,

Balasubramanian³

et al. 2016

JYP

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Objective: The current study investigates the potential of alcoholic extract of Wrightia tinctoria leaves and its isolates in repairing the DNA damage induced by gamma radiation. Methodology: The ethanolic extract of Wrightia tinctoria (EEWT) the leaves was subjected to in vitro anti oxidant assay by DPPH radical scavenging and hydrogen peroxide scavenging methods. He EEWT was investigated to the Micronucleus assay, spleen colony assay and comet assay in Sprague Dawley rats wherein DNA damage had already been induced by irradiation. Results: The ethanolic extract of Wrightia tinctoria leaves having good antioxidant activity. In the micro nucleus assay, a 2 Gy quantum of wholebody gamma radiation significantly enhanced the levels of micronucleated reticulocytes and this induction was substantially reversed in the extract treatment group. Results of the spleen colony assay pointed to the extract's ability to enhance the recovery of the hematopoietic system, in a dosedependent manner, following 6 Gy gamma irradiation. The decrease in cellular repair index due to enhanced DNA repair was evident from the comet assay parameters. Moreover, the isolates from ethanolic extract of Wrightia tinctoria, when imperiled to DNA protection by in vitro gamma radiation method in plasmid pBR322 DNA, abetted DNA repair at higher dose. Conclusion: The DNA protection afforded is likely attributable to free radical scavenging properties along with a potential for regenerating the immune system through repair of post irradiated DNA.

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Antinociceptive activity of Wrightia tinctoria bark

Cited by 16 publications

References 3 publications

Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile

Wrightia tinctoria (Roxb) R.Br. - An updated Review

Alcoholic Extract of Wrightia tinctoria leaves and Isolates there of afford DNA Protection in Post Irradiated Sprague Dawley Rats

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