Antinociceptive activity of the methanolic extract of Kaempferia galanga Linn. in experimental animals

Phytochemistry and medicinal properties of Kaempferia galanga L. (Zingiberaceae) extracts

“…A few of the medicinal properties are comparable with conventionally available medicines. For instance, analgesic effect of the herb is comparablewith the aspirin (Ridtitid et al, 2008) and the nematicidal activity is even greater than carbofuran (Tae-Kyun et al, 2010). Although this herb has been used for long time to treat swellings and arthritis (Mitra et al, 2007), the herb is not yet patented for its anti-inflammatory properties (Doreswamy, 2004).…”

“…This antinociceptive effect is reversed by naloxone in a dose of 10 mg/kg (Sulaiman et al, 2008). The capacity of the extracts to block abdominal constriction, hot plate and formaline test indicates that analgesic activity has both central mechanism, involving opioid receptors, and peripheral mechanism that involves cyclooxygenase pathway (Ridtitid et al, 2008;Sulaiman et al, 2008). incognita is 37 and 41 µg/ml, respectively that is greater than Carbofuran (92 µg/ml) but lesser than fosthiazate (2 µg/ml) (Hong et al, 2011).…”

“…When given subcutaneously in doses of 30, 100 and 300 mg/kg, the aqueous extracts of KG leaves show significant antinociceptive and anti-inflammatory effect in rats in a dosedependent manner (Sulaiman et al, 2008). When it is given orally at a dose of 200 mg/kg, the anti-nociceptive effect of KG rhizome extracts is more potent than aspirin using 100 mg/kg, but lesser than morphine using 5 mg/kg subcutaneously (Ridtitid et al, 2008). This antinociceptive effect is reversed by naloxone in a dose of 10 mg/kg (Sulaiman et al, 2008).…”

“…Responsible active constituent Possible mechanism of action Analgesic and anti-inflammatory -Central mechanism involving opioid receptors and peripheral mechanism involving cyclooxygenase pathway (Ridtitid et al, 2008;Sulaiman et al, 2008) Nematicidal activity Ethyl-trans-cinnamate, ethyl-p-methoxycinnamate (Hong et al, 2011) Mode of delivery of constituents is partly through steam phase. Mechanism is still unclear (Hong et al, 2011) Mosquito repellent and larvicidal activity Ethyl p-methoxycinnamate, ethyl-cinnamate, 3 carene, 2-propionic acid (Kim et al, 2008;Sutthanont et al, 2010) Destruction of ionic regulation in the anal gills (Insun et al, 1999) Vasorelaxant activity Ethyl-cinnamate (Othman et al, 2006) Inhibition of calcium influx into vascular cells, release of nitric oxide and prostaglandins from endothelial cells (Othman et al, 2002) Antineoplastic activity Ethyl-p-methoxycinnamate (Liu et al, 2010) Translocation of phosphatidylserine of Hep G2 cells to cell surface, resulting in an increase in sub-G cell population (Liu et al, 2010) Anti-oxidant activity Total phenolic content and flavovoids including luteolin and apigenin (Mustafa et al, 2010) -Anti microbial activity Ethyl-p-methoxycinnamat (Kanjanapothi et al, 2004a) -the antigen-induced release of -hexosaminidase in RHB-2H3 cell line (Tewtrakul et al, 2007).…”

Inhibitory Effects of Methanol Extract of Kaempferia galanga on melanogenesis in B16/F10 Melanoma Cells

“…삼내자와 관련된 국내 연구로 미백 화장료 조성물 11) , 미백 치약 조성물 12) , 미용 비누 13) 등이 있 으며, 국외 연구로는 항염증작용과 통증의 완화, 상 처 치료 등의 연구가 진행되고 있다 [14][15][16] . …”