1975
DOI: 10.1016/0014-2999(75)90048-5
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Antinociceptive action of oxotremorine and regional turnover of rat brain noradrenaline, dopamine and 5-HT

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Cited by 27 publications
(2 citation statements)
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“…Much more recently Hotovy (1956) has reported that atropine sulphate at a very low dose (30,ugkg-') is able to induce analgesia in rabbits. On the other hand it is well known that atropine administered at a much higher dosage (0.5-5.Omgkg-') antagonizes antinociception induced by cholinomimetics such as physostigmine (Ireson, 1970) and oxotremorine (Paalzow & Paalzow, 1975;Bartolini et al, 1987). Bartolini et al (1980) reported that in rodents not only is atropine (1 mg kg-', s.c.) able to decrease the pain threshold but also clearly to potentiate naloxone hyperalgesia.…”
Section: Introduction Methodsmentioning
confidence: 99%
“…Much more recently Hotovy (1956) has reported that atropine sulphate at a very low dose (30,ugkg-') is able to induce analgesia in rabbits. On the other hand it is well known that atropine administered at a much higher dosage (0.5-5.Omgkg-') antagonizes antinociception induced by cholinomimetics such as physostigmine (Ireson, 1970) and oxotremorine (Paalzow & Paalzow, 1975;Bartolini et al, 1987). Bartolini et al (1980) reported that in rodents not only is atropine (1 mg kg-', s.c.) able to decrease the pain threshold but also clearly to potentiate naloxone hyperalgesia.…”
Section: Introduction Methodsmentioning
confidence: 99%
“…This difference in finding may be due to the fact that a 5-hydroxytryptaminergic system may mediate pain mechanisms (Messing & Lytle 1977) and play a role in tremorine (Sethy et a1 1971) and presumably OTMN antinpciception in mice, whilst there is no evidence to implicate this system in cholinergic analgesia in the rat (Paalzow & Paalzow 1975;Koehn et a1 1978). It may also be possible that DFP-induced antinociception is indirectly mediated via an endogenous opioid system (Koehn et a1 1980) which is not shared by OTMN, despite the fact that the latter authors were unable to show cross tolerance between DFP and morphine, which may be expected if they share a common mechanism.…”
Section: Discussionmentioning
confidence: 90%