Antineoplastic Therapy Side Effects and Polypharmacy in Older Adults With Cancer

Stout, Nicole L.; Wagner, S

doi:10.1097/tgr.0000000000000212

Cited by 21 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Frailty is also an important consideration regarding participant composition in the included studies given that more than half of older adults with cancer experience frailty or prefrail states, 68 but only a single study included in our review measured frailty 43 . Older adults with cancer are amongst the most at‐risk for side‐effects or deleterious impacts from treatment, 69 given that more than half are frail or pre‐frail at time of diagnosis 70,71 . Because of this increased risk of treatment toxicity, 72 future interventions targeting self‐management amongst populations experiencing frailty would target a crucial unmet need.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of self‐management interventions for older adults with cancer

et al. 2021

View full text Add to dashboard Cite

Aim The purpose of this systematic review was to determine the effectiveness of self‐management interventions for older adults with cancer and to determine the effective components of said interventions. Methods We conducted a systematic review of self‐management interventions for older adults (65+) with cancer guided by the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis statement. We conducted an exhaustive search of the following databases: Ageline, AMED, ASSIA, CINAHL, Cochrane, Embase, Medline, PsychINFO, and Sociological Abstracts. We assessed for quality using the Cochrane Risk of Bias tool and Down & Black for quasi‐experimental studies, with data synthesized in a narrative and tabular format. Results Sixteen thousand nine hundred and eight‐five titles and abstracts were screened, subsequently 452 full‐text papers were reviewed by two independent reviewers, of which 13 full‐text papers were included in the final review. All self‐management interventions included in this review measured Quality of Life; other outcomes included mood, self‐care activity, supportive care needs, self‐advocacy, pain intensity, and analgesic intake; only one intervention measured frailty. Effective interventions were delivered by a multidisciplinary teams (n = 4), nurses (n = 3), and mental health professionals (n = 1). Self‐management core skills most commonly targeted included: problem solving; behavioural self‐monitoring and tailoring; and settings goals and action planning. Conclusions Global calls to action argue for increased emphasize on self‐management but presently, few interventions exist that explicitly target the self‐management needs of older adults with cancer. Future work should focus on explicit pathways to support older adults and their caregivers to prepare for and engage in cancer self‐management processes and behaviours.

show abstract

Section: Discussionmentioning

confidence: 99%

Systematic review of self‐management interventions for older adults with cancer

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Most of the chemotherapeutic drugs, with very few exceptions, are highly reactive and unselective compounds that target both normal and cancer cells. While normal cells are capable of fixing the damage eventually created by chemotherapeutics, cancer cells are not, thus making them more susceptible to the cytotoxicity [7,8].…”

Section: Introductionmentioning

confidence: 99%

Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors

et al. 2019

View full text Add to dashboard Cite

A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.

show abstract

“…It has been estimated that, especially, 40% of individuals aged over 65 years will have cancers [ 82 ]. In addition, it is known that the adverse effects of anticancer therapies increased with aging [ 83 ].…”

Section: Msc and Tissue Homeostasismentioning

confidence: 99%

Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies

Fraile

Eiró

Costa

et al. 2022

Biology

View full text Add to dashboard Cite

Aging and frailty are complex processes implicating multifactorial mechanisms, such as replicative senescence, oxidative stress, mitochondrial dysfunction, or autophagy disorder. All of these mechanisms drive dramatic changes in the tissue environment, such as senescence-associated secretory phenotype factors and inflamm-aging. Thus, there is a demand for new therapeutic strategies against the devastating effects of the aging and associated diseases. Mesenchymal stem cells (MSC) participate in a “galaxy” of tissue signals (proliferative, anti-inflammatory, and antioxidative stress, and proangiogenic, antitumor, antifibrotic, and antimicrobial effects) contributing to tissue homeostasis. However, MSC are also not immune to aging. Three strategies based on MSC have been proposed: remove, rejuvenate, or replace the senescent MSC. These strategies include the use of senolytic drugs, antioxidant agents and genetic engineering, or transplantation of younger MSC. Nevertheless, these strategies may have the drawback of the adverse effects of prolonged use of the different drugs used or, where appropriate, those of cell therapy. In this review, we propose the new strategy of “Exogenous Restitution of Intercellular Signalling of Stem Cells” (ERISSC). This concept is based on the potential use of secretome from MSC, which are composed of molecules such as growth factors, cytokines, and extracellular vesicles and have the same biological effects as their parent cells. To face this cell-free regenerative therapy challenge, we have to clarify key strategy aspects, such as establishing tools that allow us a more precise diagnosis of aging frailty in order to identify the therapeutic requirements adapted to each case, identify the ideal type of MSC in the context of the functional heterogeneity of these cellular populations, to optimize the mass production and standardization of the primary materials (cells) and their secretome-derived products, to establish the appropriate methods to validate the anti-aging effects and to determine the most appropriate route of administration for each case.

show abstract

Antineoplastic Therapy Side Effects and Polypharmacy in Older Adults With Cancer

Cited by 21 publications

References 31 publications

Systematic review of self‐management interventions for older adults with cancer

Systematic review of self‐management interventions for older adults with cancer

Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors

Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies

Contact Info

Product

Resources

About