“…Organoselenium compounds are gaining interest in the medicinal chemistry community due to their promising biological activities for a wide range of clinical applications [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Starting from Ebselen, the first compound showing the ability to function as glutathione peroxidase (GPx) mimetic [ 8 ], several Se-bearing molecules were reported as anticancer [ 9 , 10 , 11 , 12 ], anti-inflammatory [ 13 , 14 ], antidepressant [ 15 , 16 ], and antibacterial [ 17 , 18 , 19 ], among others. Worth mentioning, some of us developed the DiSeBAs class of compounds [ 20 ], endowed with a potent anti-HIV activity due to their ability to inhibit the key viral protein NCp7 [ 21 , 22 ].…”