Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties

Aboshouk, Dalia R.; Youssef, M. Adel; Bekheit, Mohamed S.; Hamed, Ahmed R.; Girgis, Adel S.

doi:10.1039/d3ra08962b

Cited by 3 publications

References 145 publications

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The Past and Future of Angiogenesis as a Target for Cancer Therapy and Prevention

Albini,

Noonan,

Corradino

et al. 2024

Cancer Prevention Research

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Cancer growth is dependent on angiogenesis, the formation of new blood vessels, which represents a hallmark of cancer. Since this concept was established in the Seventies, inhibition of tumor development and metastases by blocking the neoangiogenic process has been an important approach to the treatment of tumors. However, antiangiogenic therapies are often administered when cancer has already progressed. The key to reducing the cancer burden is prevention. We noticed 20 years ago that a series of possible cancer chemopreventive agents showed antiangiogenic properties when tested in experimental models. This article reviews the relevant advances in the understanding of the rationale for targeting angiogenesis for cancer therapy and prevention and on substances with antiangiogenic activity that may be suitable for such strategies. Many compounds, either dietary derivatives or repurposed drugs, with antiangiogenic activity are possible tools for cancer angioprevention. Such molecules have a favorable safety profile and are likely to allow the prolonged duration necessary for an efficient preventive strategy. Recent evidence on mechanisms and possible use is described here for food derivatives, including flavonoids, retinoids, triterpenoids, omega fatty acids, and carotenoids from marine microorganisms. As examples, a number of compounds, including epigallocatechin, resveratrol, xanthohumol, hydroxytyrosol, curcumin, fenretinide, lycopene, fucoxanthin, and repurposed drugs, such as aspirin, β-blockers, renin–angiotensin–aldosterone inhibitors, carnitines, and biguanides are reviewed.

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The Past and Future of Angiogenesis as a Target for Cancer Therapy and Prevention

Albini,

Noonan,

Corradino

et al. 2024

Cancer Prevention Research

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Development of 3-Indolyl Substituted Phenyl Pyrazolo-Carboxamide Hybrids as Potential Type Ii Vegfr-2 Inhibitors and in Vitro Cytotoxicity Studies

Valapil,

Devabattula,

Barahdia

et al. 2024

Preprint

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Indole Compounds in Oncology: Therapeutic Potential and Mechanistic Insights

Hassan,

Farid,

Panda

et al. 2024

Pharmaceuticals

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Cancer remains a formidable global health challenge, with current treatment modalities such as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy and adverse side effects. The indole scaffold, a prominent heterocyclic structure, has emerged as a promising candidate in the fight against cancer. This review consolidates recent advancements in developing natural and synthetic indolyl analogs, highlighting their antiproliferative activities against various cancer types over the past five years. These analogs are categorized based on their efficacy against common cancer types, supported by biochemical assays demonstrating their antiproliferative properties. In this review, emphasis is placed on elucidating the mechanisms of action of these compounds. Given the limitations of conventional cancer therapies, developing targeted therapeutics with enhanced selectivity and reduced side effects remains a critical focus in oncological research.

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Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties

Abstract: VEGF, an important category of tyrosine kinases, and its receptors (VEGFR) are hyper-activated in different cancers. The recently reported indolyl analogs with potential antineoplastic and VEGFR inhibitory properties are highlighted.

Cited by 3 publications

References 145 publications

The Past and Future of Angiogenesis as a Target for Cancer Therapy and Prevention

The Past and Future of Angiogenesis as a Target for Cancer Therapy and Prevention

Development of 3-Indolyl Substituted Phenyl Pyrazolo-Carboxamide Hybrids as Potential Type Ii Vegfr-2 Inhibitors and in Vitro Cytotoxicity Studies

Indole Compounds in Oncology: Therapeutic Potential and Mechanistic Insights

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