Antineoplastic Agents. 558. Ampelocissus sp. Cancer Cell Growth Inhibitory Constituents

Abstract

An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.

Repellent Effects of Annona Crude Seed Extract on the Asian Subterranean Termite Coptotermes gestroi Wasmann (Isoptera:Rhinotermitidae)

“…1998;Pettit et al, 2008). Annonaceous acetogenins are widely reported for its high insecticidal, molluscicidal and nematicidal properties (Rupprecht et al, 1990;McLaughlin et al, 1997;Isman, 2006).…”

In vitro cytotoxic, antifungal, trypanocidal and leishmanicidal activities of acetogenins isolated from Annona cornifolia A. St. -Hil. (Annonaceae)

“…-Hil., with orange fruits, is a small annual perennial tree found in the Brazilian savannah; their green fruit is popularly used in the treatment of ulcers (Correa 1984). Annonaceous acetogenins, isolated exclusively from the Annonaceae family until 2008(Pettit et al 2008, exhibit a broad range of biological properties (Yang et al 2009). Our group has already investigated acetogenins from the seeds of A. crassiflora (Santos et al 1994(Santos et al , 1996 and A. cornifolia (Santos et al 2006, 2007, Lima et al 2009, as well as from the leaves of Rollinia laurifolia (Pimenta et al 2001(Pimenta et al , 2003(Pimenta et al , 2005.…”

Antifungal activity of 9-hydroxy-folianin and sucrose octaacetate from the seeds of Annona cornifolia A. St. -Hil. (Annonaceae)

“…Annonaceous acetogenins are long-chain fatty acid derivatives that have been isolated exclusively from plants belonging to the Annonaceae family prior to 2008 (Pettit et al, 2008). These natural products exhibit a broad range of biological properties, such as cytotoxic, immunosuppressive, pesticidal, antiparasitic and antimicrobial activities, and their potential to inhibit cells that have multiple-drug resistance has attracted increasing interest (Bermejo et al, 2005).…”