Antineoplastic Agents. 554. The Manitoba Bacterium Streptomyces sp.^,1

Abstract

A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 microg/mL) growth of a minipanel of human cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit cancer cell growth.

Proline‐Containing Dipeptides from a Marine Sponge of a Callyspongia Species

“…podatypa [32], while other diketopiperazines were reported in the marine bacteria Pseudomonas aeruginosa [35], Halobacillus litoralis Ys3106 [38], and Streptomyces sp. [39] [40], and in the bacterial strains CF-20 and C-148 [36]. In this context, whether compounds 1 -3 are produced by the sponge or by symbiotic bacteria remains to be established.…”

Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H‐Pyrano‐[4,3‐b]pyran‐5‐one and 4,6‐Dihydro‐5H‐pyrano‐[3,2‐c]pyridine‐5‐one Scaffolds

“…Pyridone structural motif is a part of many natural and synthetic molecules, which exhibit diverse biological activities. Diazaquinomycin A shows antitumor and antibiotic properties , and it is known as nonnucleoside HIV reverse transcriptase inhibitor L‐697,661 . Phosphodiesterase inhibitor milrinone is used in the treatment of heart failure ( Fig.…”

Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants

“…Many of today's medicines are either obtained directly from a natural source or were developed from a lead compound originally from a natural source (Patrick 2005). However, one crucial aspect to be considered for a successful drug discovery program from natural products is selection of the natural source to be studied (Guimaraes et al 2008).…”