Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants

Hsieh, Pei Wen; Hsu, Li Chi; Lai, Chian-Hui; Wu, Chin Chung; Hwang, Tsong‐Long; Lin, Yin Ku; Wu, Yang Chang

doi:10.1007/s11274-009-0036-0

Cited by 14 publications

(10 citation statements)

References 58 publications

(56 reference statements)

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“…Presently, L. octovalvis is being explored in several biotherapy and anticancer studies (4–6). In some wetland ecosystems, L. octovalvis is also considered an invasive plant (7, 8).…”

Section: Genome Announcementmentioning

confidence: 99%

Complete Plastome Sequence of Ludwigia octovalvis (Onagraceae), a Globally Distributed Wetland Plant

et al. 2016

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“…Presently, L. octovalvis is being explored in several biotherapy and anticancer studies (4–6). In some wetland ecosystems, L. octovalvis is also considered an invasive plant (7, 8).…”

Section: Genome Announcementmentioning

confidence: 99%

Complete Plastome Sequence of Ludwigia octovalvis (Onagraceae), a Globally Distributed Wetland Plant

et al. 2016

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“…The crude extract exploited by Thronton media was categorized as nontoxic by NCI (National Cancer Institute) which defined IC 50 of crude extract over 30 µg/mL as noncytotoxic ( 14 , 32 ). The tested SUK 25 extracts were nontoxic against mammalian Chang liver cells with IC 50 values of 43.31 ± 1.24 µg/mL.…”

Section: Discussionmentioning

confidence: 99%

Anti-Methicillin Resistant Staphylococcus aureus Activity and Optimal Culture Condition of Streptomyces sp. SUK 25

Junaidah

Sudi

Sidek

et al. 2015

Jundishapur J Microbiol

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Background:The potential of secondary metabolites extracted from Streptomyces sp. to treat bacterial infections including infections with Staphylococcus aureus is previously documented. The current study showed significant antimicrobial activities associated with endophytic Streptomyces sp. isolated from medicinal plants in Peninsular Malaysia.Objectives:The current study aimed to determine anti-methicillin-resistant-Staphylococcus aureus (MRSA) activities of Streptomyces sp. isolates.Materials and Methods:Disc diffusion and Minimum Inhibitory Concentration (MIC) assay were used to determine the antibacterial activity of Streptomyces sp. isolates. Optimization of fermentation parameters for the most potent anti-MRSA extract in terms of medium type, pH, aeration rate, and culture period was also carried out. Lastly, toxicity of the extract against Chang liver cells was determined employing the MTT, 2- (3, 5- diphenyltetrazol-2-ium-2-yl) -4, 5-dimethyl -1, 3 - thiazole; bromide assay.Results:The results indicated Streptomyces sp. SUK 25 isolates showed the most potent anti-MRSA activity. Disc diffusion assay revealed that spread plate technique was more efficient in screening anti-MRSA activity compared to pour plate (P < 0.05). To determine anti–MRSA MIC of Streptomyces sp. SUK 25, Thronton media was used. Therefore, MIC was determined as 2.44 ± 0.01 µg/mL, and accordingly, the lowest MIC was 1.95 µg/mL based on a seven-day culture, pH7, and aeration rate of 140 rpm. The crude extract was not toxic against Chang liver cells (IC50 = 43.31 ± 1.24 µg/mL).Conclusions:The Streptomyces sp. SUK 25 culturing was optimized using Thronton media, at pH 7 and aeration of 140 rpm. Further isolation and identification of bioactive compounds will develop anti-MRSA therapeutics.

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“…and Fusarium sp.) isolated from Artemisia argyi proved cytotoxic against liver cancer cell lines (Hep G2) [ 67 ]. Similarly, Pestalotiopsis hainanensis was active against all tested cell lines (MCF-7 breast, COLO205 colon, and HL-60 leukemia), while Phomopsis mali and Rhodotorula glutinis inhibited the HL-60 leukemia cell line, Alternaria sp.…”

Section: Biological Activity Of Artemisia Endopmentioning

confidence: 99%

Endophytic Fungi in Species of Artemisia

Cosoveanu

Cabrera

2018

JoF

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The genus Artemisia, a collection of ~400 hardy herbaceous plant and shrub species, is an important resource contributing to chemistry, medicine, agriculture, industry, and ecology. Its communities of endophytic fungi have only recently begun to be explored. Summarized from studies conducted on the fungal endophytes in Artemisia species, both fungal phylogenetic diversity and the associated bioactivity was examined. Isolations from 14 species of Artemisia have led to 51 genera of fungal endophytes, 28 families, and 18 orders. Endophytes belonged mainly to Ascomycota, except for two taxa of Cantharellales and Sporidiobolales, one taxon of Mucoromycota, and one species of Oomycota. The mostly common families were Pleosporaceae, Trichocomaceae, Leptosphaeriaceae, and Botryosphaeriaceae (relative abundance = 14.89, 8.51, 7.14 and 6.38, respectively). In the search for bioactive metabolites, 27 novel compounds were characterized and 22 metabolites were isolated between 2006 and 2017. The first study on endophytic fungi isolated from species of Artemisia was published but 18 years ago. This summary of recently acquired data illustrates the considerable diversity of biological purposes addressed by fungal endophytes of Artemisia spp.

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Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants

Cited by 14 publications

References 58 publications

Complete Plastome Sequence of Ludwigia octovalvis (Onagraceae), a Globally Distributed Wetland Plant

Complete Plastome Sequence of Ludwigia octovalvis (Onagraceae), a Globally Distributed Wetland Plant

Anti-Methicillin Resistant Staphylococcus aureus Activity and Optimal Culture Condition of Streptomyces sp. SUK 25

Endophytic Fungi in Species of Artemisia

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