Antineoplastic activity of selected constituents of Duguetia glabriuscula

Matos, Maria Auxiliadora Costa; Leite, Lima; Brustolim, D.; Siqueira, João Máximo de; Carollo, Carlos Alexandre; Hellmann, Aline Regina; Pereira, Núbia Fernanda Gomes; Silva, Denise Brentan

doi:10.1016/j.fitote.2006.01.013

Cited by 27 publications

(28 citation statements)

References 9 publications

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“…It has been reported to be an agonist of liver X receptors, thus increasing cellular cholesterol efflux, lowering LDL, and raising HDL levels [22]. Other unique bioactive properties of polycarpol include antineoplastic [23] and antifilarial [24] activities, and cytotoxicity [25]. In the current study, its flat structure was identified on the basis of one-and two dimensional NMR data, while analysis of its ROESY spectrum confirmed the configuration.…”

Section: Resultssupporting

confidence: 54%

Antiproliferative compounds ofArtabotrys madagascariensisfrom the Madagascar rainforest

Murphy¹,

Cao²,

Brodie³

et al. 2008

Natural Product Research

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Bioassay-guided fractionation of an ethanol extract of Artabotrys madagascariensis led to the isolation of the new compound artabotrol A (1), two butenolides (2 and 3), and the tetracyclic triterpene polycarpol (4). Structure elucidation was determined on the basis of one and twodimensional NMR, and absolute configuration of compounds 2-4 was verified by analysis of CD and optical rotation spectra. Two of the isolates, melodorinol (2) and acetylmelodorinol (3), were found to display antiproliferative activity against five different tumor cell lines with IC 50 values ranging from 2.4 to 12 µM.

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Section: Resultssupporting

confidence: 54%

Antiproliferative compounds ofArtabotrys madagascariensisfrom the Madagascar rainforest

Murphy¹,

Cao²,

Brodie³

et al. 2008

Natural Product Research

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“…All the compounds isolated in this study have been previously isolated from different species (Mata et al, 1991;Olivera-Ortega et al, 1999;Nguyen et al, 2004;Oviedo-Chávez et al, 2004;Matos et al, 2006). However, ␤-amyrin and ␤-sitosterol were isolated for the first time from the Cyrtocarpa procera hexane extract.…”

Section: Nomentioning

confidence: 94%

“…␤-sitosterol has also been described to have activity as cytotoxic (Nguyen et al, 2004;Matos et al, 2006), antioxidant (Vivancos and Moreno, 2005;Ai-li and Changhai, 2006), anti-inflammatory (Gupta et al, 1980;Gómez et al, 1999) antihyperglycemic (Ortiz-Andrade et al, 2006), sedative and anxiolytic (Aguirre-Hernández et al, 2007) and gastro-protective (Navarrete et al, 2002). With regard to ␤-amyrin, this compound has been described as possessing anti-inflammatory, antinociceptive, and cytotoxic (Oliveira et al, 2004) qualities.…”

Section: Nomentioning

confidence: 99%

Anti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in rats

Rosas-Acevedo

Terrazas

González-Trujano

et al. 2011

Journal of Ethnopharmacology

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“…Caffeic acid derivatives can be found in PNE. Previous reports show that friedelin, sitosterol, some fatty acids and phenolic acids present cytotoxicity to several strains (Begin et al, 1988;Hoi et al, 2013;Matos et al, 2006;Ozcelik et al, 2011;Thao et al, 2010;Velasquez et al, 1993). Therefore, the presence of those compounds might explain the cytotoxicity observed.…”

Section: Resultsmentioning

confidence: 93%

Cytotoxic effect of Plectranthus neochilus extracts in head and neck carcinoma cell lines

Borges¹,

Ferreira²,

Elias³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Following a tendency of studying the potential effects of plant extracts to cancer, this study aimed to evaluate in vitro the cytotoxic activity of Plectranthus neochilus (PN) extracts and its fractions in head and neck squamous cell carcinoma (HNSCC) cell lines and assess their tumor specificity. MTT assay was conducted with two HNSCC cell lines, FaDu (hypopharynx carcinoma) and SCC-25 (tongue carcinoma), one keratinocyte (HaCat) and one fibroblast (L929) cell line. Two PN leaf crude extracts, one ethanolic (E) and one hexanic (H), and their nine fractions were tested. A dose-response curve was performed with hexane PNH fraction and a tumor specificity index (TSI) was calculated. For all cell lines studied, almost all extracts and fractions resulted in cell viability lower than 50%. Hexane and methanol PNH fractions were exceptions, causing a significantly low viability in SCC-25 (17.16 and 34.53%, respectively), but higher than 50% in FaDu, HaCat and L929. The dose-response curve with hexane PNH fraction resulted in a CC 50 of 540.9 µg/mL for FaDu, 550 µg/mL for L929, 762.1 µg/mL for HaCat and 274.2 µg/mL for SCC-25. The TSI L929/FaDu was 1.01, HaCat/FaDu was 1.40, L929/SCC-25 was 2.00 and HaCat/SCC-25 was 2.77. TSIs indicate its specificity for tongue carcinoma cells, when compared to fibroblasts and keratinocytes.

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Antineoplastic activity of selected constituents of Duguetia glabriuscula

Cited by 27 publications

References 9 publications

Antiproliferative compounds ofArtabotrys madagascariensisfrom the Madagascar rainforest

Antiproliferative compounds ofArtabotrys madagascariensisfrom the Madagascar rainforest

Anti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in rats

Cytotoxic effect of Plectranthus neochilus extracts in head and neck carcinoma cell lines

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