Antiproliferative compounds ofArtabotrys madagascariensisfrom the Madagascar rainforest

Abstract

Bioassay-guided fractionation of an ethanol extract of Artabotrys madagascariensis led to the isolation of the new compound artabotrol A (1), two butenolides (2 and 3), and the tetracyclic triterpene polycarpol (4). Structure elucidation was determined on the basis of one and twodimensional NMR, and absolute configuration of compounds 2-4 was verified by analysis of CD and optical rotation spectra. Two of the isolates, melodorinol (2) and acetylmelodorinol (3), were found to display antiproliferative activity against five different tumor cell lines with IC 50 values ranging from 2.4 to 12 µM.

Toward the Total Synthesis of Klaivanolide: Complete Reinterpretation of Its Originally Assigned Structure

“…Reassignment of the structure of klaivanolide led us to propose structure 12 , which is already known in the literature as acetylmelodorinol, originally isolated from Melodorum fruticosum 17 and later from other Annonaceae such as Mitrella kentii 18 and Artabotrys madagascaiensis 19. Analysis of the NMR spectroscopic data between isolated “klaivanolide” and acetylmelodorinol showed that they are identical.…”

Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis

“…A compound named artabotrene has been described in the literature and assigned the structure 1a (Murphy et al, 2008). Its NMR data closely matched those of compound 1 , and it has a positive optical rotation.…”

Polycarpol in Unonopsis, Bocageopsis and Onychopetalum Amazonian species: chemosystematical implications and antimicrobial evaluation

“…This idea was supported over the years (Goulart et al, 1986;Jung et al, 1990). Polycarpol was recently isolated from Duguetia glabriuscula (Pereira et al, 2003), Duguetia furfuraceae (Silva et al, 2007), Artabotrys madagascariensis (Murphy et al, 2008), Piptostigma preussi (Ngantchou et al, 2009) and Artabotrys spinosus (Sichaem et al, 2011), all species from Annonaceae family, which has enhances the initial proposition of this compound as a chemotaxonomic marker for this family. Considering its broad occurrence at genera level, is appropriate to restrict the term "chemotaxonomic marker" at family level, being suggested the use of the term "chemical marker" to genera level.…”