Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic

Mostafavi, Ebrahim; Zarepour, Atefeh; Barabadi, Hamed; Zarrabi, Ali; Truong, Linh; Medina-Cruz, David

doi:10.1016/j.btre.2022.e00714

Cited by 81 publications

(28 citation statements)

References 112 publications

(118 reference statements)

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“…In recent decades, the development of nanotechnology resulted in the design of various nanomaterials for biological and therapeutic applications such as gene therapy, tissue engineering, drug delivery, molecular imaging, etc. [ 1 , 2 , 3 , 4 ]. In comparison with conventional therapies, nanomaterials are more efficient for cancer therapy because they can be designed appropriately to target affected tumor sites and discriminatorily distribute their loads with fewer side effects.…”

Section: Introductionmentioning

confidence: 99%

NIR-Triggered Generation of Reactive Oxygen Species and Photodynamic Therapy Based on Mesoporous Silica-Coated LiYF4 Upconverting Nanoparticles

Yang

Jiang

et al. 2022

IJMS

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To date, the increase in reactive oxygen species (ROS) production for effectual photodynamic therapy (PDT) treatment still remains challenging. In this study, a facile and effective approach is utilized to coat mesoporous silica (mSiO2) shell on the ligand-free upconversion nanoparticles (UCNPs) based on the LiYF4 host material. Two kinds of mesoporous silica-coated UCNPs (UCNP@mSiO2) that display green emission (doped with Ho3+) and red emission (doped with Er3+), respectively, were successfully synthesized and well characterized. Three photosensitizers (PSs), merocyanine 540 (MC 540), rose bengal (RB), and chlorin e6 (Ce6), with the function of absorption of green or red emission, were selected and loaded into the mSiO2 shell of both UCNP@mSiO2 nanomaterials. A comprehensive study for the three UCNP@mSiO2/PS donor/acceptor pairs was performed to investigate the efficacy of fluorescence resonance energy transfer (FRET), ROS generation, and in vitro PDT using a MCF-7 cell line. ROS generation detection showed that as compared to the oleate-capped and ligand-free UCNP/PS pairs, the UCNP@mSiO2/PS nanocarrier system demonstrated more pronounced ROS generation due to the UCNP@mSiO2 nanoparticles in close vicinity to PS molecules and a higher loading capacity of the photosensitizer. As a result, the three LiYF4 UCNP@mSiO2/PS nanoplatforms displayed more prominent therapeutic efficacies in PDT by using in vitro cytotoxicity tests.

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Section: Introductionmentioning

confidence: 99%

NIR-Triggered Generation of Reactive Oxygen Species and Photodynamic Therapy Based on Mesoporous Silica-Coated LiYF4 Upconverting Nanoparticles

Yang

Jiang

et al. 2022

IJMS

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“…The biogenic nanoparticles facilitate excessive production of ROS and apoptotic enzymes that contributes to higher cytotoxicity in cancer cells [ 122 ]. Mostafavi et al described the efficiency of biogenic AgNPs and AuNPs for antineoplastic activity against leukemic models [ 123 ]. Barabadi et al .…”

Section: Nanocarrier-based Drug Delivery Systems To Overcome Mdrmentioning

confidence: 99%

Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer

2022

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Cancer often develops multidrug resistance (MDR) when cancer cells become resistant to numerous structurally and functionally different chemotherapeutic agents. MDR is considered one of the principal reasons for the failure of many forms of clinical chemotherapy. Several factors are involved in the development of MDR including increased expression of efflux transporters, the tumor microenvironment, changes in molecular targets and the activity of cancer stem cells. Recently, researchers have designed and developed a number of small molecule inhibitors and derivatives of natural compounds to overcome various mechanisms of clinical MDR. Unfortunately, most of the chemosensitizing approaches have failed in clinical trials due to non-specific interactions and adverse side effects at pharmacologically effective concentrations. Nanomedicine approaches provide an efficient drug delivery platform to overcome the limitations of conventional chemotherapy and improve therapeutic effectiveness. Multifunctional nanomaterials have been found to facilitate drug delivery by improving bioavailability and pharmacokinetics, enhancing the therapeutic efficacy of chemotherapeutic drugs to overcome MDR. In this review article, we discuss the major factors contributing to MDR and the limitations of existing chemotherapy- and nanocarrier-based drug delivery systems to overcome clinical MDR mechanisms. We critically review recent nanotechnology-based approaches to combat tumor heterogeneity, drug efflux mechanisms, DNA repair and apoptotic machineries to overcome clinical MDR. Recent successful therapies of this nature include liposomal nanoformulations, cRGDY-PEG-Cy5.5-Carbon dots and Cds/ZnS core–shell quantum dots that have been employed for the effective treatment of various cancer sub-types including small cell lung, head and neck and breast cancers. Graphical Abstract

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“…Biogenic gold nanoparticles are free from hazardous by-products which are generally found in case of chemical synthesis, that resulted in minimising usage in different applications [ 128 ]. To be used in biomedical applications, gold nanoparticles must be biocompatible.…”

Section: Advantages Of Biologically Synthesized Gold Nanoparticlesmentioning

confidence: 99%

Biologically Derived Gold Nanoparticles and Their Applications

Roy

Pandit

Gacem

et al. 2022

Bioinorganic Chemistry and Applications

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Nanotechnology is a rapidly evolving discipline as it has a wide variety of applications in several fields. They have been synthesized in a variety of ways. Traditional processes such as chemical and physical synthesis have limits, whether in the form of chemical contamination during synthesis operations or in subsequent applications and usage of more energy. Over the last decade, research has focused on establishing easy, nontoxic, clean, cost-effective, and environmentally friendly techniques for nanoparticle production. To achieve this goal, biological synthesis was created to close this gap. Biosynthesis of nanoparticles is a one-step process, and it is ecofriendly in nature. The metabolic activities of biological agents convert dissolved metal ions into nanometals. For biosynthesis of metal nanoparticles, various biological agents like plants, fungus, and bacteria are utilized. In this review paper, the aim is to provide a summary of contemporary research on the biosynthesis of gold nanoparticles and their applications in various domains have been discussed.

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Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic

Cited by 81 publications

References 112 publications

NIR-Triggered Generation of Reactive Oxygen Species and Photodynamic Therapy Based on Mesoporous Silica-Coated LiYF4 Upconverting Nanoparticles

NIR-Triggered Generation of Reactive Oxygen Species and Photodynamic Therapy Based on Mesoporous Silica-Coated LiYF4 Upconverting Nanoparticles

Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer

Biologically Derived Gold Nanoparticles and Their Applications

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