2020
DOI: 10.1101/2020.05.16.100123
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Antimycobacterial potential of Mycobacteriophage under disease-mimicking conditions

Abstract: Antibiotic resistance continues to be a major global health risk with an increase in multi-drug resistant infections seen across nearly all bacterial diseases. This global burden is further pronounced by the misuse of antibiotics and the availability of only a handful of antibiotics in the development pipeline. Amongst the drug-resistant infections, mycobacterial infections such as Tuberculosis (TB) and Non-Tuberculosis infections have seen a significant increase in the incidence of multi-drug resistant and ex… Show more

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Cited by 4 publications
(6 citation statements)
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References 85 publications
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“…We thank the Molecular Reproduction, Development and Genetics, and Materials Engineering common facility for instrument access. The manuscript has been released as a pre-print at BioRxiv ( Kalapala et al, 2020 ).…”
mentioning
confidence: 99%
“…We thank the Molecular Reproduction, Development and Genetics, and Materials Engineering common facility for instrument access. The manuscript has been released as a pre-print at BioRxiv ( Kalapala et al, 2020 ).…”
mentioning
confidence: 99%
“…The following cell lines were used in this study: HEK293T cells expressing human ACE2 (NR-52511, BEI Resources, NIAID, NIH); HEK293T (NCCS, Pune, amplified in M. smegmatis and phage enumeration was done using the soft agar overlay technique as reported by Kalapala et al (Kalapala et al, 2020).…”
Section: Cell Linesmentioning
confidence: 99%
“…C, SRM University, Andhra Pradesh. TM4 mycobacteriophage (Bajpai et al, 2018) was amplified in M. smegmatis and phage enumeration was done using the soft agar overlay technique as reported by Kalapala et al (Kalapala et al, 2020).…”
Section: Experimental Model and Subject Detailsmentioning
confidence: 99%
“…A recent study has reported that a cocktail of phages was effective in inhibiting M. smegmatis growth under acidic, hypoxic and stationary phase growth conditions [107].…”
Section: Challenges Towards Intracellular Phage Therapymentioning
confidence: 99%
“…This would ensure that the evolving phage-resistant population will still be susceptible to other phages in the cocktail [110][111][112]. A phage cocktail was shown to reduce development of phage tolerance in M. smegmatis and M. tuberculosis compared to treatment with single phages [107]. Broad-range lytic phages need to be identified or developed and tested against clinical strains and demographically predominant strains in addition to lab strains [113][114][115].…”
Section: Challenges Towards Intracellular Phage Therapymentioning
confidence: 99%