Antimycobacterial and cytotoxicity activity of synthetic and natural compounds

Souza, Ana Olı́via de; Galetti, Fábio C. S.; Silva, Célio Lopes; Bicalho, Beatriz; Parma, M. M.; Fonseca, S.F.; Marsaioli, Anita Jocelyne; Trindade, Angela Cristina Leal Badaró; Gil, Rossimíriam P. Freitas; Bezerra, Franciglauber Silva; Andrade‐Neto, Manoel; Oliveira, Maria C. F. de

doi:10.1590/s0100-40422007000700012

Cited by 99 publications

(72 citation statements)

References 16 publications

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“…Imine or azomethine groups are present in various natural, natural-derived, and non natural compounds. The imine group present in such compounds has been shown to be critical to their biological activities [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

Sadeek¹,

El‐Attar²,

El‐Hamid³

2015

Bull. Chem. Soc. Eth.

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ABSTRACT. Some new transition metal complexes of ciprofloxacin-imine derived from ciprofloxacin and ophenylenediamine were synthesized and characterized on the basis of melting point, magnetic moment, conductance measurements, elemental analysis, infrared, UV/Vis, nuclear magnetic resonance spectroscopy, mass spectra as well as thermal analyses. The data indicate that the ligand acts as tetradentate chelate bound to the metal ions through the deprotonated carboxylate and the azomethine group. The ligand as well as their metal complexes was also evaluated for their antibacterial activity against several bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and also, fungicidal activity aganist Candida albicans and Aspergillus fumigatus were tested. It was found that the metal complexes are more antibacterial as compared to uncomplexes ligand and no antifungal activity observed for ligand and their complexes. Also, this study showed that the ciprofloxacin-imine is more antibacterial as compared to ciprofloxacin alone.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

Sadeek¹,

El‐Attar²,

El‐Hamid³

2015

Bull. Chem. Soc. Eth.

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“…To CuCl 2 Á2H 2 O (2mmol) dissolved in aqueous/ethanol solution (1:2v/v) was added ligand HL 21 (2mmol) dissolved in hot ethanol and refluxing for 2h. The green-brown precipitate, which separated on cooling, was filtered, washed with hot water, ethanol followed by ether, and dried in vacuo.…”

Section: Descriptive Inorganic Chemistry Researches Of Metal Compoundmentioning

confidence: 99%

“…The complexes and ligands HL [21][22][23][24] were tested for their in vitro antibacterial activity against de Staphylococcus aureus var. Oxford 6538, Klebsiella pneumoniae ATCC 100131, Escherichia coli ATCC 10536, and Pseudomonas aeruginosa ATCC 9027 strains using the paper disc diffusion method (for the qualitative determination) and the serial dilutions in liquid broth method (for determination of MIC) [66].…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Schiff bases can be regarded as promising antimicrobial agents. For example, N-(salicylidene)-2-hydroxyaniline proved efficiency against Mycobacterium tuberculosis H37Rv, exhibiting an MIC value of 8μg/mL [21]. The 5-chloro-salicylaldehyde-Shiff base derivatives are efficient against Pseudomonas fluorescence (MIC=2.5-5.2μg/mL), Escherichia coli (MIC=1.6-5.7μg/mL), Bacillus subtilis (MIC=1.8μg/mL), and Staphylococcus aureus (MIC=1.6 and 3.1μg/mL), respectively, while the MIC values for the reference drug kanamycin against the same bacterial strains were 3.9μg/mL [22].…”

Section: Introductionmentioning

confidence: 99%

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Transition Metal Complexes with Antipyrine‐Derived Schiff Bases: Synthesis and Antibacterial Activity

Pahontu¹

2017

Descriptive Inorganic Chemistry Researches of Metal Compounds

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The increase of death rate, associated with infectious diseases, is directly linked to the bacteria that have multiple resistance to antibiotics. The lack of efficient medical treatment is the main cause of this problem. The synthesis of new antibacterial agents, through various methods, is, for sure, an emergency medical issue. Recent research focuses more and more on the synthesis of complexes of the transitional metals with ligands of Schiff-base type, as a result of the biological properties which they have. This article presents the synthesis of several complexes with base Schiff ligands, derived from 4-aminoantipyrine and in vitro research of their antibacterial activities. The new compounds were tested for their in vitro antibacterial activity against Staphylococcus aureus var. Oxford 6538, Klebsiella pneumoniae ATCC 100131, Escherichia coli ATCC 10536, and Pseudomonas aeruginosa ATCC 9027 strains. Based on the "in vitro" studies, we can say that ten of the complexes synthetized can be successfully used instead of streptomycin, where there is resistance to this antibiotic.

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“…bacterial [1], antifungal [2]properties. Meanwhile, Schiff bases have also been found to be useful ligands to form stable complexes with avariety of transition metal ions [3][4].…”

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confidence: 99%

Crystal structure of (E)-2,3-dibromo-4-((2,6-diisopropylphenylimino) methyl)-6-methoxyphenol, C20H23Br2NO2

Zhang¹,

Ge²,

Cui³

2012

Zeitschrift für Kristallographie - New Crystal Structures

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C 20 H 23 Br 2 NO 2 , P1 (No.2), a =12.629(8) Å, b =12.653(8) Å, c =14.032(9) Å, a =71.268(6)°, b =81.172(7)°, g =76.448(6)°, V =2056.9Å 3 , Z =4,R gt (F) =0.0410,Source of material 2,3-Dibromo-4-hydroxy-5-methoxybenzaldehyde (0.310g, 1mmol) and 2,6-diisopropylaniline (0.1780g, 1mmol) were mixed in methanol (20 mL). Them ixture was stirred at room temperature for 10-12 hourst og ive ay ellow solution. Yellow block-shaped single crystals were obtained by slow evaporation of the solution containing the compound in air. Experimental detailsAll Hatomswere positioned geometrically (C-H =0.93-0.96 Å) and were refined as riding, with U iso (H) =1 .2U eq (carrier) or 1.5U eq (methyl C). DiscussionSchiff bases have acted as important precursors for compounds reported to possess avariety of biological activities, such as anti-properties. Meanwhile, Schiff bases have also been found to be useful ligands to form stable complexes with avariety of transition metal ions [3][4]. As an extension of our work on the structural characterization of Schiff base compounds [5][6][7], in this paper we present an ew structure of a Schiff base compound. In the title compound, all the bond lengths are within normalranges [9]. There are two independent molecules in the asymmetric unit of the title compound (see the Figure) and each molecule of the compound exists in a trans configuration with respect to the C=N double bond. The dihedral angle between the benzene ring with two bromide substituents and the benzene ring with two isopropyl substituents is 50.3(2)°. There are intramolecular O1-H1×××N2 and O3-H3×××N1 hydrogen bonds. Their symmetry code are (1-x, 1-y,1-z) and (1-x,-y,1-z) respectively. In addition, the C14-H14B-p interaction with a 2.590Å distance of C14-Cg(1) exist in the compound. These hydrogen bonds and the C14-H14B-p interaction determines the molecule packing in the structure.

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Antimycobacterial and cytotoxicity activity of synthetic and natural compounds

Cited by 99 publications

References 16 publications

Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

Synthesis and characterization and antibacterial activity of some new transition metal complexes with ciprofloxacin-imine

Transition Metal Complexes with Antipyrine‐Derived Schiff Bases: Synthesis and Antibacterial Activity

Crystal structure of (E)-2,3-dibromo-4-((2,6-diisopropylphenylimino) methyl)-6-methoxyphenol, C20H23Br2NO2

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