Antimutagens from Plumeria acuminata Ait

Guevara, Amelia; Amor, Evangeline C.; Russell, Graeme B.

doi:10.1016/s0165-1161(96)90240-x

Cited by 35 publications

(24 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25][26][27][28] Ursolic acid isolated from the ethanolic fraction of Eriobotrya japonica markedly and significantly decreased the numbers of S. typhimurium TA100 revertants per plate, thus showing antimutagenic activity. 29 In addition, lupeol, a triterpene that has had its pharmacological properties approved, was present.…”

Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Lira

Santos

Sannomiya

et al. 2008

Journal of Medicinal Food

View full text Add to dashboard Cite

Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian "cerrado" (tropical American savanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceae family, and it is commonly known as "murici." Considering the popular use of B. basiloba derivatives and the lack of pharmacological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) and chloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella typhimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and indirect mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B 1 , benzo[a]pyrene, and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level (89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B 1 . Phytochemical analysis of the extracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (ϩ)-catechin, quercetin-3-O-␣-L-arabinopyranoside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2Љ-O-galloyl)-␤-D-galactopyranoside, and quercetin-3-O-(2Љ-O-galloyl)-␣-L-arabinopyranoside.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Lira

Santos

Sannomiya

et al. 2008

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…Also, its administration to mice at a dose of 80 mg/kg reduced the number of micro-nucleated polychromatic erythrocytes induced by the mutagen mitomycin C by 76% [104].…”

Section: Mutagenesis and Carcinogenesismentioning

confidence: 99%

Ursolic acid: An anti‐ and pro‐inflammatory triterpenoid

Ikeda

Murakami

Ohigashi

2008

Molecular Nutrition Food Res

374

252

View full text Add to dashboard Cite

There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.

show abstract

“…The root contains iridoids: 13-O-caffeoylplumieride, 13-deoxyplumieride, β-dihydroplumericinic acid glucosyl ester plumenoside, 1α-plumieride, 8-isoplumieride, 1α-protoplumericin A (Abe et al 1988). The leaf contains L-(+)-bornesitol) (Nishibe et al 1971); triterpenoids: ursolic acid, lupeol acetate (Guevara et al 1996). The flower contains essential oils: β-linalool, cis-geraniol, trans-nerolidol (Huang et al 2005), and β-citronellol (Lin et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Larvicidal activity of silver nanoparticles synthesized using Plumeria rubra plant latex against Aedes aegypti and Anopheles stephensi

et al. 2011

View full text Add to dashboard Cite

In the present study activity of silver nanoparticles (AgNPs) synthesized using Plumeria rubra plant latex against second and fourth larval instar of Aedes aegypti and Anopheles stephensi was determined. Range of concentrations of synthesized AgNps (10, 5, 2.5, 1.25, 0.625, 0.3125 ppm) and aqueous crude latex (1,000, 500, 250, 125, 62.50, 31.25 ppm) were tested against larvae of A. aegypti and A. Stephensi. The synthesized AgNps from P. rubra latex were highly toxic than crude latex extract in both mosquito species. The LC(50) values for second and fourth larval instars after 24 h of crude latex exposure were 1.49, 1.82 ppm against A. aegypti and 1.10, 1.74 ppm against A. stephensi respectively. These figures were 181.67, 287.49 ppm against A. aegypti and 143.69, 170.58 ppm against A. stephensi respectively for crude latex extract. The mortality rates were positively correlated with the concentration of AgNPs. The characterization studies of synthesized AgNPs by UV-Vis spectrophotometry, transmission electron microscopy (TEM), Particle size analysis (PSA) and zeta potential confirmed the spherical shape and size (32-200 nm) of silver nanoparticles along with stability. Toxicity studies carried out against non-target fish species Poecilia reticulata, the most common organism in the habitats of A. aegypti and A. stephensi showed no toxicity at LC(50) and LC(90) doses of the AgNPs. This is the first report on mosquito larvicidal activity of latex synthesized nanoparticles.

show abstract

Antimutagens from Plumeria acuminata Ait

Cited by 35 publications

References 3 publications

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Ursolic acid: An anti‐ and pro‐inflammatory triterpenoid

Larvicidal activity of silver nanoparticles synthesized using Plumeria rubra plant latex against Aedes aegypti and Anopheles stephensi

Contact Info

Product

Resources

About