Antimutagenicity and Cytotoxicity of the Constituents from the Aerial Parts of Rumex acetosa

Abstract

Four anthraquinones isolated for the first time from the aerial parts of Rumex acetosa (Polygonaceae), a Korean and a Japanese medicinal plant, and two synthetic derivatives were examined for their cytotoxicities against five cultured human tumor cell lines, i.e. A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCY15 (colon), using the Sulfrhodamine-B method in vitro and antimutagenic activities by Ames test with Salmonella typhimurium TA98 and TA100 and SOS chromotest with E. coli PQ37. Among the tested compounds, emodin strongly inhibited the proliferation of each examined tumor cell line with IC 50 values ranged from 2.94 to 3.64 m mg/ml and showed potent antimutagenic activities with 71.5% and 53.3% at the concentration of 0.1 mg/plate against the mutagens, NPD and sodium azide, respectively. Its antigenotoxic activity was also very effective at the final concentration of 10 m mg/reaction tube against the mutagens, MNNG and NQO by SOS chromotest, reducing the induction factors by 19.6% and 43.5%, respectively. The structure-activity correlation study suggests that an additional OH group at C-6 position in the anthraquinone nucleus may play an important role for their cytotoxicities and an introduction of OH-or OCH 3 group at C-6 position is necessary for their antimutagenicities.

Characterization of the complete chloroplast genome of sorrel (Rumex acetosa)

“…Characterization of the complete chloroplast genome of sorrel (Rumex acetosa) Rumex acetosa L. (Polygonaceae), a dioecious plant which has a multiple sex chromosome system (Shibata et al 1999(Shibata et al , 2000, is a perennial herb, commonly known as sheep's sorrel, red sorrel, sour weed, and field sorrel (Lee et al 2005). As a traditional medicine plant, it was shown to have some pharmacological activities, including anti-inflammatory, antioxidant (Wegiera et al 2007), anti-tumor, antibacterial, antiviral, and anti-fungal properties (Taylor et al 1996;Demirezer et al 2001;Lee et al 2005).…”

“…As a traditional medicine plant, it was shown to have some pharmacological activities, including anti-inflammatory, antioxidant (Wegiera et al 2007), anti-tumor, antibacterial, antiviral, and anti-fungal properties (Taylor et al 1996;Demirezer et al 2001;Lee et al 2005). Meanwhile, its leaves are widely used in sauces and salads (Ahmad et al 2006).…”

Aqueous Extracts of Dried Fruits of <i>Zanthoxylum armatum</i> DC., (Rutaceae) Induce Cellular and Nuclear Damage Coupled with Inhibition of Mitotic Activity <i>in Vivo</i>

“…Spiridonov et al, [25] reported acute in vitro cytotoxicity of Potentilla erecta extracts, which is used for alleviating symptoms of disease in cancer patients. The extracts of aerial parts of Rumex acetosa used in traditional Korean and Japanese medicine is also reported to show toxicity in vitro [26]. Similar reports are also available for Plantago sp used in traditional Spanish medicine [27].…”

Antioxidative Effects and Component Analysis of Extracts of the Rumex acetosa L.

“…수영의 잎은 유럽이나 미국에 존재하는 강한 신맛이 나는 시금치와 비슷하게 생겼으며, sorrel이라 는 이름으로도 알려져 있는 식물이다 [18]. 수영(R. acetosa)의 추출물은 해열, 이뇨, 살충, 항균, 항암활성 등에 효능이 있다고 알려져 있다 [20][21][22]. 또한, 수영을 달인 물은 관절염, 위염, 위궤양 등의 치료에 민간요 법으로 쓰이는 것으로 보고되고 있다.…”

“…또한, 수영을 달인 물은 관절염, 위염, 위궤양 등의 치료에 민간요 법으로 쓰이는 것으로 보고되고 있다. 수영의 성분으 로는 잎에서 vitexin과 quercitrin [23], 뿌리에서 chrysophanol을 비롯한 anthraquinone 및 그 배당체 [24], 지 상부에서 orientin을 비롯한 플라보노이드류 및 그 배 당체 [25]가 보고되어 있다 [25][26][27].…”