Antimutagenic effect of resveratrol against Trp-P-1

Uenobe, Fukuji; Nakamura, Seiichi; Miyazawa, Mitsuo

doi:10.1016/s0027-5107(96)00191-1

Cited by 144 publications

(78 citation statements)

References 12 publications

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“…Arachis hypogea (Ingham et al, 1976), Polygonum cuspidatum (Arichi et al, 1982), Yucca schidigera (Uenobe et al, 1997)]. The biological function of transResveratrol is thought to be the protection of plants from environmental stress and fungal attack (Soleas et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures

Tyihák²,

2000

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Experimental data suggest that Resveratrol, a compound found in grapes and other fruits may influence cell proliferation and apoptosis. The aim of our experiments was to study the effect of Resveratrol on tumor cell cultures and an endothelial cell culture in order to examine the effect of various doses of this compound on active cell death and cell proliferation. Human tumor (HT-29, SW-620, HT-1080) and endothelial (HUV-EC-C) cells were treated with various doses of (0.1 to 100.0 µg/ml) Resveratrol in vitro. Cell number, apoptotic and mitotic index was measured 24, 48 and 72 h after treatment. Low doses (0.1-1.0 µg/ml) of Resveratrol enhance cell proliferation, higher doses (10.0-100.0 µg/ml) induce apoptosis and decrease mitotic activity, which is reflected in changes of cell number. Resveratrol influences dose dependently the proliferative and apoptotic activity of human tumor and endothelial cells. The possible role of formaldehyde in the mechanism of action of Resveratrol is discussed.

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Section: Introductionmentioning

confidence: 99%

Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures

Tyihák²,

2000

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“…In animal studies, resveratrol interfered with the formation of azoxymethane-(AOM) induced aberrant crypt foci in rat colon (Tessitore et al, 2000), attenuated oesophageal carcinoma formation in rats that received N-nitrosomethylbenzylamine (NMBA) , decreased the number of adenomas in the small intestine and suppressed tumour formation in the colon of Apc Min þ mice (Schneider et al, 2001) and reduced mammary tumour formation in N-methyl-Nnitrosourea-(NMU) treated rats (Bhat et al, 2001). Resveratrol has been reported to possess a variety of anti-inflammatory, antiplatelet and both pro-and antioestrogenic effects (Bertelli et al, 1996;Gehm et al, 1997;Jang et al, 1997;Uenobe et al, 1997). It exerts a wide variety of biological effects germane to cancer chemoprevention, including the inhibition of cytochrome P450 enzyme expression activity (Chun et al, 1999;Guengerich et al, 2003), induction of apoptosis (Mahyar-Roemer et al, 2001, modulation of components of the cell cycle machinery (Schneider et al, 2000;Wolter et al, 2001), decrease in cyclooxygenase 1 (COX-1) activity and COX-2 expression (Subbaramaiah et al, 1998;Mutoh et al, 2000;Li et al, 2002), antioxidation (Sgambato et al, 2001), inhibition of activities of protein kinase C and D (Haworth Revised 17 October 2003;accepted 17 November 2003 andAvkiran, 2001;Slater et al, 2003) and decrease in the activity of transcription factors NFkB and AP-1 (Surh et al, 2001;Banerjee et al, 2002).…”

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confidence: 99%

Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene

et al. 2004

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Resveratrol (trans-3,5,4 0 -trihydroxystilbene) is a naturally occurring polyphenol with cancer chemopreventive properties in preclinical models of carcinogenesis, including those of colorectal cancer. Recently, a variety of analogues of resveratrol have been synthesised and investigated in in vitro assays. One analogue, 3,4,5,4 0 -tetramethoxystilbene (DMU 212), showed preferential growth-inhibitory and proapoptotic properties in transformed cells, when compared with their untransformed counterparts. As part of a chemoprevention drug development programme, the pharmacokinetic properties of DMU 212 were compared with those of resveratrol in the plasma, liver, kidney, lung, heart, brain and small intestinal and colonic mucosa of mice. DMU 212 or resveratrol (240 mg kg À1 ) were administered intragastrically, and drug concentrations were measured by HPLC. Metabolites were characterised by cochromatography with authentic reference compounds and were identified by mass spectrometry. The ratios of area of plasma or tissue concentration vs time curves of resveratrol over DMU 212 (AUC res /AUC DMU212 ) for the plasma, liver, small intestinal and colonic mucosa were 3.5, 5, 0.1 and 0.15, respectively. Thus, resveratrol afforded significantly higher levels than DMU 212 in the plasma and liver, while DMU 212 exhibited superior availability compared to resveratrol in the small intestine and colon. Resveratrol was metabolised to its sulphate or glucuronate conjugates, while DMU 212 underwent metabolic hydroxylation or single and double O-demethylation. DMU 212 and resveratrol inhibited the growth of human-derived colon cancer cells HCA-7 and HT-29 in vitro with IC 50 values of between 6 and 26 mM. In the light of the superior levels achieved in the gastrointestinal tract after the administration of DMU 212, when compared to resveratrol, the results provide a good rationale to evaluate DMU 212 as a colorectal cancer chemopreventive agent.

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“…Resveratrol is abundant in red wine with concentrations ranging from 10 to 20 M [6,7]. The works show that Resveratrol is rapidly absorbed and metabolized.…”

Section: Discussionmentioning

confidence: 99%

“…It also protects against lipid peroxidation in cell membranes and DNA damage caused by reactive oxygen species generation [4]. Resveratrol was further demonstrated to be an antitumor and chemopreventive agent; and found to affect cellular proliferation through its action on tumor initiation, promotion, and progression [5,6]. These properties have been explained mainly by its activities in cell cycle control and apoptosis induction [7,8].…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent effect of Resveratrol on bladder cancer cells: Chemoprevention and oxidative stress

et al. 2012

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Antimutagenic effect of resveratrol against Trp-P-1

Cited by 144 publications

References 12 publications

Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures

Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures

Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene

Dose-dependent effect of Resveratrol on bladder cancer cells: Chemoprevention and oxidative stress

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