Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause

Cui, Linlin; Qin, Yingying; Gao, Xuan; Lu, Jun; Geng, Ling; Ding, Lingling; Qu, Zhipeng; Zhang, Xiruo; Chen, Zi‐Jiang

doi:10.1016/j.fertnstert.2015.10.017

Cited by 74 publications

(71 citation statements)

References 30 publications

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“…Lee used a non‐commercial ELISA assay with the lower limit of detection at 0.5 ng/mL (3.58 pmol/L) and Hagen used the Immunotech Beckman Coulter assay with a lower limit of detection at 2 pmol/L (0.28 ng/mL). A more recent study by Cui in 2016 using the ANSH lab assay shows serum AMH levels of 1.66 mg/L at birth. The lower limit of detection for this assay was 0.08 mg/L.…”

Section: Resultsmentioning

confidence: 96%

“…The weighted mean for serum AMH from 0 to 1 years was 10.55 pmol/L (1.48 ng/mL) (data pooled from studies by Lee, Cui and Johannsen) with the weighted median being 9.85 pmol/L (1.38 ng/mL) (data pooled from studies from Lee, Hagen, Sir‐Petermann and Cui) . (Table , Figure ).…”

Section: Resultsmentioning

confidence: 98%

“…Six cross‐sectional studies used cross‐sectional data to report the mean/median serum AMH with the reference ranges (SD/10th‐90th/5‐95th/2.5‐97.5th centile) from birth into adult life . Six studies reported this data in a longitudinal study design .…”

Section: Resultsmentioning

confidence: 99%

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Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Bhide

Pundir

Homburg

et al. 2019

Acta Obstet Gynecol Scand

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Introduction Certain medical disorders as well as their management may affect gonadal function. Recent advances in the management of these conditions accompanied by the availability and success of methods of fertility preservation has highlighted the need for assessment of ovarian reserve in childhood and adolescence. Serum anti‐Mullerian hormone (AMH) and antral follicle count are well established markers of ovarian reserve and serum inhibin has also been used. However, literature on reference ranges for ovarian reserve markers in this age‐group is relatively scarce. Thus, our aim was to evaluate published data to estimate reference values of ovarian reserve makers in childhood and adolescence. Material and methods We performed a systematic review of the literature reporting ovarian reserve markers in childhood and adolescence. We included only those studies examining markers of ovarian reserve in the normal healthy population between the ages of 0 and 19 years. PROSPERO registration: CRD42018119064. Results Serum AMH emerged as the most common biomarker assessed. Serum AMH was detectable at birth and, after a transient increase in infancy, increased steadily in childhood. Following a slight decrease at puberty, levels were constant throughout adolescence with a peak in adolescence or early adulthood. The mean serum AMH values during infancy, childhood and adolescence were 10.55, 22.32 and 31.84 pmol/L, respectively. The corresponding median values were 9.85, 24.49 and 26.32 pmol/L. It was not possible to construct age‐specific reference intervals because of methodological heterogeneity, variations in the assay used to measure AMH and differing interval width for age used in included studies. Serum inhibin showed an increase from childhood to adolescence, with median serum inhibin values of 53.86 pg/mL in adolescence. Antral follicle count showed a significant positive correlation with serum AMH and a median value of 30.52 in adolescence. Conclusions We summarize the trends and levels of biomarkers of ovarian reserve from birth until young adulthood. Peak levels of serum AMH are reported in adolescence or early adulthood. We have reported median/mean values for serum AMH in different age‐groups based on data pooled from several studies, which may be used as a reference when evaluating ovarian reserve in childhood and adolescence especially when considering fertility preservation.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 98%

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Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Bhide

Pundir

Homburg

et al. 2019

Acta Obstet Gynecol Scand

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“…Similarly, in a birth cohort study of >1300 adolescent girls (mean age 15.5), neither birth weight nor current BMI were associated with AMH levels (52, 53). Cross-sectional analyses in Chinese girls also reported no associations of BMI in childhood (ages 0–10 years) or adolescence (ages 11–18 years) with AMH measured concurrently (54). In contrast, in a study of adolescent girls who were normal (n=43), oligomenorrheic (n=27), or had polycystic ovarian syndrome (n=150), AMH levels were significantly lower in obese compared to non-obese girls within each group (55).…”

Section: Discussionmentioning

confidence: 99%

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Bertrand

Baer

Orav

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Emerging evidence suggests positive associations between serum antimüllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk. Methods We examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC). Height and weight were measured at baseline (ages 8–10) and throughout adolescence. Serum AMH concentrations and breast density were assessed at ages 25–29 at the DISC06 Follow-Up visit. We used linear mixed effects models to quantify associations of AMH (dependent variable) with quartiles of age-specific youth body mass index (BMI) Z-scores (independent variable). We assessed cross-sectional associations of breast density (dependent variable) with AMH concentration (independent variable). Results Neither early life BMI nor current adult BMI was associated with AMH concentrations. There were no associations between AMH and percent or absolute dense breast volume. In contrast, women with higher AMH concentrations had significantly lower absolute non-dense breast volume (p-trend <0.01). Conclusions We found no evidence that current or early life BMI influences AMH concentrations in later life. Women with higher concentrations of AMH had similar percent and absolute dense breast volume, but lower non-dense volume. Impact These results suggest that AMH may be associated with lower absolute non-dense breast volume; however, future prospective studies are needed to establish temporality.

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“…Natural menopause is a physiologic manifestation of a depleted follicular pool. Elevated follicle-stimulating hormone (FSH) and luteinizing hormone levels, and low anti-Mullerian hormone (AMH; a hormone used to estimate ovarian reserve (35)) are hallmark biochemical signs of menopause (33, 36). Menopause is preceded by a transition period (perimenopause) that can last several years starting from when a woman enters her fourth decade of life (33).…”

Section: Menopausementioning

confidence: 99%

Cosmetics use and age at menopause: is there a connection?

Chow

Mahalingaiah

2016

Fertility and Sterility

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Short Narrative Abstract Cosmetics contain a vast number of chemicals, most of which are not under the regulatory purview of the Food and Drug Administration. Only a few of these chemicals have been evaluated for potential deleterious health impact – parabens, phthalates, polycyclic aromatic hydrocarbons, and siloxanes. A review of the ingredients in the best-selling and top rated products of the top beauty brands in the world, as well as a review of highlighted chemicals by non-profit environmental organizations reveal 11 chemicals and chemical families of concern: butylated hydroxyanisole/butylated hydroxytoluene, coal tar dyes, diethanolamine, formaldehyde releasing preservatives, parabens, phthalates, 1,4 dioxane, polycyclic aromatic hydrocarbons, siloxanes, talc/asbestos, and triclosan. Age at menopause can be affected by a variety of mechanisms, including endocrine disruption, failure of DNA repair, oxidative stress, shortened telomere length, and ovarian toxicity. There is a lack of available studies to make a conclusion regarding cosmetics use and age at menopause. What little data there is suggests future studies are warranted. Women with chronic and consistent use of cosmetics across their lifespan may be a population of concern. More research is required to better elucidate the relationship and time windows of vulnerability and the effects of mixtures and combinations of products on ovarian health.

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Antimüllerian hormone: correlation with age and androgenic and metabolic factors in women from birth to postmenopause

Abstract: From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve.

Cited by 74 publications

References 30 publications

Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women

Cosmetics use and age at menopause: is there a connection?

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