Antimüllerian hormone and polycystic ovary syndrome

Lin, Yi Hui; Chiu, Wan‐Chun; Wu, Chien Hua; Tzeng, Chii‐Ruey; Hsu, Chia-Hsiang; Hsu, Ming Jen

doi:10.1016/j.fertnstert.2011.04.003

Cited by 103 publications

(81 citation statements)

References 11 publications

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“…The purported relationship between insulin resistance and metabolic syndrome with AMH has been a source of controversy [26,29]. In our study, AMH was not related to insulin resistance-or metabolic syndrome-related variables, irrespective of the PCOS status, and is in agreement with other studies [8,11].…”

Section: Discussionsupporting

confidence: 93%

“…However, serum AMH level was not higher in the overweight/obese PCOS group than in the non-obese PCOS group. There have been a few studies that have previously reported serum AMH level reflected severity of PCOS [8,11]. Considering these earlier results, overweight/obese PCOS group could not be regarded as the more severe PCOS group although they were evaluated as distinct from the other three groups and appeared to reflect a greater influence due to obesity than observed in other groups.…”

Section: Comparison Of Clinical and Biochemical Data Between Women Wimentioning

confidence: 87%

“…A cutoff level of 7.82 ng/mL (AURC 0.868, sensitivity 75.9%, specificity 86.8%) was obtained in this study. This value represents an average across the two threshold AMH concentrations previously reported, 7.3 ng/mL (sensitivity 70%, specificity 76%) [8] and 8.4 ng/mL (sensitivity 67%, specificity 92%) [25]. Differences in the cutoff values may be attributed to the different inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

“…Differences in the cutoff values may be attributed to the different inclusion criteria. In Lin's study [8], PCOS-risk cases with one of three PCOS components were classified into non-PCOS group, while these same PCOS-risk cases were excluded from the control group in Pigny [25] and in our study. There were a few studies that performed ROC curve analysis for the cutoff of biochemical parameters of hyperandrogenism other than AMH for the diagnosis of PCOS [30,31].…”

Section: Discussionmentioning

confidence: 99%

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Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

et al. 2012

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POLYCYSTIC OVARY SYNDROME (PCOS) is one of the most common endocrinological problems in women. In addition to chronic oligo-anovulation, the main features of the PCOS include elevated levels of circulating androgens and/or clinical hyperandrogenism, polycystic ovary morphology, altered gonadotropin secretion, insulin resistance and/or compensatory hyperinsulinemia often associated with obesity [1]. Women affected by PCOS also show a higher risk of type 2 diabetes, dyslipidemia, hypertension and cardiovascular diseases [2][3][4].Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome Abstract. The aim of the present study was to compare the associations of anti-Müllerian hormone (AMH) with clinical or biochemical characteristics between women with and without polycystic ovary syndrome (PCOS). We also explored the optimal cutoff point of AMH to diagnose PCOS. A cross-sectional study was performed in 87 women diagnosed with PCOS and 53 healthy control subjects. Body mass index (BMI), indices of insulin resistance, metabolic syndrome-related variables, reproductive hormones and serum AMH were measured in all subjects. We conducted receiver operating characteristic (ROC) curve analysis to determine the cutoff of AMH for diagnosis of PCOS. Serum AMH levels were significantly (p <0.001) higher in women with PCOS after adjustment for age and BMI. AMH levels were not significantly related with obesity, indices of insulin resistance, and metabolic syndrome-related variables in both PCOS and control groups. In the control group, AMH levels showed positive correlations with total testosterone (p <0.001), free testosterone (p=0.024), and adiponectin (p=0.002), and showed negative correlations with age (p=0.010) and estradiol (E2) (p=0.012). However, only total (p=0.044) and free testosterone (p=0.012) levels showed significant positive correlations with serum AMH level in PCOS group. ROC curve analysis showed a cutoff point for AMH of 7.82 ng/mL (sensitivity 75.9%, specificity 86.8%) for diagnosis of PCOS. Differences of the association of AMH with clinical or biochemical characteristics between women with PCOS and control groups were observed. This might contribute to the pathogenesis of PCOS, although further investigation is necessary to elucidate the detailed mechanism.

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Section: Discussionsupporting

confidence: 93%

Section: Comparison Of Clinical and Biochemical Data Between Women Wimentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

et al. 2012

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“…Therefore, serum AMH levels increase by 2-3-fold in women with early stage PCOS compared with normal controls. The sensitivity of serum AMH for diagnosis of PCOS ranges from 64 to 99 % [60][61][62][63][64][65][66][67][68]. The wide range of sensitivities among studies is likely due to variations in diagnostic criteria and in the age of the patient population.…”

Section: Diagnosis Of Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Anti‐Müllerian hormone as a marker of ovarian reserve: What have we learned, and what should we know?

Iwase

Nakamura

Osuka

et al. 2015

Reprod Medicine & Biology

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Ovarian reserve reflects the quality and quantity of available oocytes. This reserve has become indispensable for the better understanding of reproductive potential. Measurement of the serum anti-Müllerian hormone (AMH) level allows quantitative evaluation of ovarian reserve. It has been applied to a wide range of clinical conditions, and it is well established that the measurement of serum AMH levels is more useful than qualitative evaluation based on the menstrual cycle. AMH levels are monitored during infertility treatments; in patients undergoing medically assisted reproductive technology; and in the diagnosis of ovarian failure, polycystic ovarian syndrome, and granulosa cell tumor. It is also useful in the evaluation of iatrogenic ovarian damage. Population-based studies have indicated a potential role for serum AMH in the planning of reproductive health management. While AMH is currently the best measure of ovarian reserve, its predictive value for future live births remains controversial. Furthermore, there is a serious practical issue in the interpretation of test results, as currently available assay kits use different assay ranges and coefficients of variation due to the absence of an international reference standard. The pros and cons of the serum AMH level as a definitive measure of ovarian reserve merits further review in order to guide future research.

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Correlations among anti‐Müllerian hormone levels, body mass index and lipid profile in reproductive‐aged women: The Korea Nurses' Health Study

Lim

Kim

et al. 2021

Nursing Open

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Antimüllerian hormone and polycystic ovary syndrome

Cited by 103 publications

References 11 publications

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

Differences of the association of anti-Müllerian hormone with clinical or biochemical characteristics between women with and without polycystic ovary syndrome

Anti‐Müllerian hormone as a marker of ovarian reserve: What have we learned, and what should we know?

Correlations among anti‐Müllerian hormone levels, body mass index and lipid profile in reproductive‐aged women: The Korea Nurses' Health Study

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