Antimicrobial triterpenes fromIlex integra and the mechanism of antifungal action

Haraguchi, Hiroyuki; Kataoka, Shintaro; Okamoto, Shiho; Hanafi, Muhammad; Shibata, Kozo

doi:10.1002/(sici)1099-1573(199903)13:2<151::aid-ptr391>3.0.co;2-c

Cited by 77 publications

(28 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, studies have demonstrated that extract of genus Ilex possessed anticariogenic properties (Tsai, Chien, Lee, & Tsai, 2008). It has also been demonstrated that triterpenoids isolated from the genus Ilex showed significantly broad antimicrobial activity (Haraguchi, Kataoka, Okamoto, Hanafi, & Shibata, 1999), which suggested that triterpenoids could be the components active against oral pathogens. But there are few data or observations concerning triterpenoids of this genus acting against oral pathogens.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of triterpenoids in different parts of Ilex hainanensis, Ilex stewardii and Ilex pubescens using HPLC–ELSD and HPLC–MSn and antibacterial activity

et al. 2011

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of triterpenoids in different parts of Ilex hainanensis, Ilex stewardii and Ilex pubescens using HPLC–ELSD and HPLC–MSn and antibacterial activity

et al. 2011

View full text Add to dashboard Cite

“…Sterols and triterpenes were stated to possess antifungal activity [46][47][48]. A study suggested that the antifungal activity of triterpenes was due to membrane lipid alteration which resulted in a change of membrane permeability [49].…”

Section: Discussionmentioning

confidence: 99%

Anti-infective Properties of Brachychiton rupestris and Brachychiton luridum Leaves and their Qualitative Phytochemical Screening

Marasabessy¹,

Rudiyono²,

Dewi³

2017

Med Aromat Plants

View full text Add to dashboard Cite

Brachychiton rupestris and Brachychiton luridum are deciduous trees belonging to family Malvaceae. Several members of the genus Brachychiton and its related genus, Sterculia, are used in folk medicine for the treatment of infections. Herein, we investigated the antimicrobial activity of the total extracts, n-hexane, dichloromethane as well as the ethyl acetate fractions of the leaves of both species using agar well diffusion method in an effort to better consolidate the scientific basis for their traditional uses. The study was carried out against two Gram-positive and two Gram-negative bacteria together with two fungi. The extracts and fractions showed mean inhibition zones diameter in the range of 10.97-14.98 mm with minimum inhibitory concentration values ranging between 39.06 and 625 µg/mL against the susceptible bacteria and fungi. The ethyl acetate fraction of B. luridum exhibited notable activity against Staphylococcus aureus while the total extract showed moderate activity against Salmonella typhi. Regarding B. rupestris, the total extract, n-hexane and ethyl acetate fractions showed moderate activity against Escherichia coli, Candida albicans, and Salmonella typhi, respectively. Other extracts and fractions showed weak or no activity against the tested microorganisms. Qualitative phytochemical screening of both plants was performed to preliminary unveil the classes of secondary metabolites present in the leaves. The results indicated the existence of flavonoids, tannins, sterols, triterpenes, carbohydrates and/or glycosides in both plants.

show abstract

“…Results suggest that the antifungal activity can be correlated with the presence of sitosterol in the C. leptophylla extract, and stigmasterol in I. marginata. These compounds according to Haraguchi et al (1999) could change the membrane permeability arising from membrane lipid alteration, thus promoting the fungal inhibition.…”

Section: Antimicrobial Activities: Phytopathogenic Filamentous Fungimentioning

confidence: 99%

Antimicrobial activity of Brazilian plants of the genera Leguminosae and Myrtaceae

Daniel¹,

Iwasso²,

Fiorini³

et al. 2014

J. Med. Plants Res.

View full text Add to dashboard Cite

Five Brazilian plant extracts from Pimenta pseudocaryophyllus, Erythrina speciosa, Tephrosia toxicaria, Inga marginata and Cassia leptophylla found in Paraná State and currently used in folkloric medicines, were assayed for antibacterial, antifungal and toxic activities. The antibacterial and anti-yeast activities were assessed by a diffusion assay on Gram (+) bacteria (Bacillus subtilis and Staphylococcus aureus), Gram (-) bacteria (Escherichia coli and Pseudomonas aeruginosa), and the yeasts (Candida albicans, Candida krusei, and Candida tropicalis). The extracts were also tested against the phytopathogenic fungi (Lasiodiplodia theobromae, Botryosphaeria ribis, Botryosphaeria rhodina, and Fusarium verticillioides) by growth inhibition using Captan™ as control. The toxicity was evaluated in Artemia salina through LC 50 (50% median lethal concentration) using Probit analysis. P. aeruginosa was inhibited by P. pseudocaryophyllus stems, E. speciosa and C. lephophylla leaves. E. coli by P. pseudocaryophyllus stems, B. subtilis by C. leptophylla leaves, and T. toxicaria roots. C. albicans by P. pseudocaryophyllus stems and E. speciosa leaves, while C. krusei by P. pseudocaryophyllus stems, and C. tropicalis by P. pseudocaryophyllus leaves, E. speciosa leaves and I. marginata leaves. E. speciosa and P. pseudocaryophyllus leaf extracts also inhibited all the phytopathogenic fungi examined. T. toxicaria roots showed stronger toxicity towards A. salina.

show abstract

Antimicrobial triterpenes fromIlex integra and the mechanism of antifungal action

Cited by 77 publications

References 39 publications

Quantitative analysis of triterpenoids in different parts of Ilex hainanensis, Ilex stewardii and Ilex pubescens using HPLC–ELSD and HPLC–MSn and antibacterial activity

Quantitative analysis of triterpenoids in different parts of Ilex hainanensis, Ilex stewardii and Ilex pubescens using HPLC–ELSD and HPLC–MSn and antibacterial activity

Anti-infective Properties of Brachychiton rupestris and Brachychiton luridum Leaves and their Qualitative Phytochemical Screening

Antimicrobial activity of Brazilian plants of the genera Leguminosae and Myrtaceae

Contact Info

Product

Resources

About