Antimicrobial therapy of methicillin resistant Staphylococcus aureus infection

Khare, Milind; Keady, Deirbhile

doi:10.1517/eoph.4.2.165.21082

Cited by 8 publications

(11 citation statements)

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“…Teicoplanin is a glycopeptide antibiotic used against methicillin‐resistant gram‐positive infections 1 . It is generally well tolerated at therapeutic doses 2 .…”

Section: What Is Known and Objectivementioning

confidence: 99%

Complete heart block in a patient with acute lymphoblastic leukaemia: teicoplanin as a possible cause and review of literature

Sharif‐Yakan

Arabi

Musharrafıeh

et al. 2012

Journal of Clinical Pharmacy and Therapeutics

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SUMMARYWhat is known and Objective: Teicoplanin is a glycopeptide antibiotic used against documented or presumed methicillin-resistant infections. We report a 31-month-old boy with acute lymphocytic leukaemia who developed permanent complete atrioventricular block (CAVB) necessitating pacemaker insertion after receiving teicoplanin for Staphylococcus epidermidis bacteremia. Case summary: Clinical assessment of the child revealed febrile neutropenia. After thorough assessment and work-up, the patient was started on teicoplanin intravenously after which he had sudden onset of bradycardia. Electrocardiography showed CAVB that eventually required permanent pacemaker insertion. Twenty-nine months from the incident, the patient is doing well. What is new and Conclusion: We report on a case of teicoplanin-associated CAVB in a child with acute lymphoblastic leukaemia (ALL). This is one of only two similar cases reported in the literature. Teicoplanin remains the most probable cause. The use of teicoplanin should be approached cautiously in the setting of immunosuppression. Whether VZV contributed and teicoplanin triggered remains speculative. Physicians should be aware of this possible complication. WHAT IS KNOWN AND OBJECTIVETeicoplanin is a glycopeptide antibiotic used against methicillinresistant gram-positive infections.1 It is generally well tolerated at therapeutic doses.2 Complete atrioventricular block (CAVB) induced by teicoplanin has been reported once in the literature. 3 We report another case of teicoplanin-induced CAVB in a child with acute lymphoblastic leukaemia (ALL). To the best of our knowledge, only one other similar case has been reported. DETAILS OF THE CASEA 31-month-old boy diagnosed at the age of 16 months with intermediate-risk T-cell ALL presented to the hospital for maintenance chemotherapy week #51 that consisted of 6-mercaptopurine (6-MP) at a dose of 60 mg/m 2 /day and methotrexate at 40 mg/ m 2 /week. Clinical assessment of the child on admission revealed febrile neutropenia which prevented the patient's receipt of the recommended chemotherapy. Fever work-up including blood cultures was performed, and the patient was discharged after receiving a single dose of ceftriaxone intravenously. Three days later, blood cultures showed coagulase-negative, gram-positive cocci identified as Staphylococcus epidermidis and the child was called for further management.On presentation, the patient was stable and in no acute distress. His vital signs were as follows: temperature of 36AE2°C, heart rate of 126 bpm, respiratory rate of 26 breaths per minute and blood pressure of 101/50 mmHg with 100% oxygen saturation. His electrocardiography (EKG) showed normal sinus rhythm. After re-evaluation of the patient and based on his previous studies and blood cultures, he was started on teicoplanin intravenously at a dose of 10 mg/kg twice daily. Fifteen hours later, there was sudden onset of bradycardia with the heart rate reaching 45 bpm. There was no obvious clinical distress, and cardiac examination revealed nor...

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“…Teicoplanin is a glycopeptide antibiotic used against methicillin‐resistant gram‐positive infections 1 . It is generally well tolerated at therapeutic doses 2 .…”

Section: What Is Known and Objectivementioning

confidence: 99%

Complete heart block in a patient with acute lymphoblastic leukaemia: teicoplanin as a possible cause and review of literature

Sharif‐Yakan

Arabi

Musharrafıeh

et al. 2012

Journal of Clinical Pharmacy and Therapeutics

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“…To a solution of 3 (428 mg, 1.25 mmol) in EtOH (4.12 mL) were added hydroxylamine hydrochloride (435 mg, 6.25 mmol) and NaHCO 3 (525 mg, 6.25 mmol). The mixture was heated under reflux overnight.…”

Section: N-((s)-3-{3-fluoro-4-[3-(n-hydroxycarbamimidoyl)-pyrrol-1-ylmentioning

confidence: 99%

“…1,2 Infections caused by these organisms pose a serious challenge to the scientific community and the need for an effective therapy has lead to a search for novel antibacterial agents. Oxazolidinones are a novel class of totally synthetic antimicrobial agents active against Gram-positive pathogenic bacteria including methicillin-resistant Staphylococcus aureus (MRSA), 3,4 vancomycin-resistant Enterococcus faecium (VRE), 5 and penicillin-resistant Streptococcus pneumoniae (PRSP). 6,7 Linezolid (1) is the first member of this class currently launched worldwide, and available in both intravenous and oral formulations.…”

mentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel Substituted Pyrrolyl and Pyrazolyl Oxazolidinone Analogues

2009

Bulletin of the Korean Chemical Society

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“…Linezolid aus der neuen Klasse der Oxazolidinone hemmt die ribosomale Proteinbiosynthese grampositiver Erreger [278]. Es kann sowohl i. v. als auch p. o. verabreicht werden (Bioverfügbarkeit nahe 100 %) [19,184]. Linezolid ist gegen Vancomycin-resistente E. faecium und gegen Vancomycin-resistente E. faecalis bakteriostatisch wirksam.…”

Section: Oxazolidinone: Linezolidunclassified

“…MRSA sind resistent gegen alle Betalaktam-Antibiotika. "Arbeitspferde" gegen MRSA sind daher die Glykopeptide [184,253]. Die Entdeckung von zwei Vanco-resistenten S.-aureus-Isolaten (VRSA) im Jahre 2002 [53,376] und eines dritten Isolates im April 2004 [84] hat auch bei MRSA-Infektionen das Augenmerk auf mögliche Alternativen gelenkt.…”

Section: Therapie Ausgewählter Infektionenunclassified

Therapie bakterieller Infektionen in der pädiatrischen Onkologie

Simon

Beutel²,

Marklein³

et al. 2005

Klin Padiatr

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ZusammenfassungOhne den sachkundigen Einsatz von Antibiotika kann das Ziel einer intensiveren Chemotherapie und letztlich eines verbesserten Langzeitüberlebens in der pädiatrischen Onkologie nicht erreicht werden. Während der Granulozytopenie und auch zwischen den intensiven Chemotherapien können bakterielle Infektionen die Lebensqualität des Patienten beeinträchtigen, das Leben des Patienten akut gefährden und den Ressourcenverbrauch im Rahmen der erforderlichen supportiven Behandlung massiv erhöhen. Der unkritische und nicht standardisierte Umgang mit Antibiotika kann den Patienten unnötigerweise mit Nebenwirkungen belasten und zur Selektion resistenter Bakterienspezies führen. Die vorliegende Arbeit enthält Empfehlungen der Arbeitsgruppe „Infektionen bei immunsupprimierten Kindern” der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI) und der Deutschen Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) zur gezielten Therapie mit Antibiotika, insoweit sie für die Behandlung pädiatrisch-onkologischer Patienten von Interesse sind.

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Antimicrobial therapy of methicillin resistant Staphylococcus aureus infection

Cited by 8 publications

References 0 publications

Complete heart block in a patient with acute lymphoblastic leukaemia: teicoplanin as a possible cause and review of literature

Complete heart block in a patient with acute lymphoblastic leukaemia: teicoplanin as a possible cause and review of literature

Synthesis and Biological Evaluation of Novel Substituted Pyrrolyl and Pyrazolyl Oxazolidinone Analogues

Therapie bakterieller Infektionen in der pädiatrischen Onkologie

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