Therapie bakterieller Infektionen in der pädiatrischen Onkologie

Simon, Arne; Beutel, Karin; Marklein, G; Fleischhack, Gudrun

doi:10.1055/s-2005-872500

Klin Padiatr

2005

DOI: 10.1055/s-2005-872500

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Therapie bakterieller Infektionen in der pädiatrischen Onkologie

Arne Simon

Karin Beutel²,

G Marklein³

et al.

Abstract: ZusammenfassungOhne den sachkundigen Einsatz von Antibiotika kann das Ziel einer intensiveren Chemotherapie und letztlich eines verbesserten Langzeitüberlebens in der pädiatrischen Onkologie nicht erreicht werden. Während der Granulozytopenie und auch zwischen den intensiven Chemotherapien können bakterielle Infektionen die Lebensqualität des Patienten beeinträchtigen, das Leben des Patienten akut gefährden und den Ressourcenverbrauch im Rahmen der erforderlichen supportiven Behandlung massiv erhöhen. Der unkr… Show more

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Cited by 2 publications

References 367 publications

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Bloodstream infection in paediatric cancer centres—leukaemia and relapsed malignancies are independent risk factors

Ammann

Schrey

et al. 2015

Eur J Pediatr

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• Paediatric cancer patients face an increased risk of nosocomial bloodstream infections (BSIs). • In most cases, these BSIs are associated with the use of a long-term central venous catheter (Broviac, Port), severe and prolonged immunosuppression (e.g. neutropenia) and other chemotherapy-induced alterations of host defence mechanisms (e.g. mucositis). What is New: • This study is the first multicentre study confirming relapsed malignancy as an independent risk factor for BSIs in paediatric cancer patients. • It describes the epidemiology of nosocomial BSI in paediatric cancer patients mainly outside the stem cell transplantation setting during conventional intensive therapy and argues for prospective surveillance programmes to target and evaluate preventive bundle interventions.

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Bloodstream infection in paediatric cancer centres—leukaemia and relapsed malignancies are independent risk factors

Ammann

Schrey

et al. 2015

Eur J Pediatr

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Effectiveness of bacterial infection-related cytokine profile (BIRCP) determination for monitoring pathogen infections in children with hemopathy in the bone marrow inhibition phase

Chen

Tang

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Serum cytokine profiles were analyzed before and after infection in children with hemopathy in the bone marrow inhibition phase to explore the utility of cytokine variations for detecting infections. Serum Th1/Th2 cytokine levels, including tumor necrosis factor, interleukin (IL)-2, IL-4, IL-6, IL-10, and interferon, were quantitatively determined by cytometric bead array technology in 480 cases (230 children) of children with hemopathy in the bone marrow inhibition phase with signs of infection, such as fever, and without, to establish baseline and affected levels for comparison with healthy control children. We used the cytokine profile of infected, blood culture-positive children to establish a bacterial infection-related cytokine profile (BIRCP) for Usefulness of BIRCP in monitoring pathogen infections predicting infections by pathogens in blood culture-negative children. Overall, 82.9% of children with Gram-negative bacterial infections were accompanied by marked increases of IL-6 and IL-10 levels [>10 times (means ± SD)], whereas only a mild increase of IL-6 levels occurred in Gram-positive bacteria-infected children [>2 times (means ± SD)] and only a mild increase of IFN-γ levels occurred in fungal culturepositive children [>2 times (means ± SD)]. Gram-positive bacterial and fungal infections did not cause a marked increase in IL-6 or IL-10 levels. The effective rate (86.05%, N = 43) of infectious cases predicted by BIRCP was significantly higher than that obtained using traditional methods for selecting antibiotics based on clinical indications (65.45%, N = 55, P < 0.05). In summary, BIRCP can be used to predict the infections by pathogens in children with hemopathy and to select appropriate antibiotics.

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Therapie bakterieller Infektionen in der pädiatrischen Onkologie

Cited by 2 publications

References 367 publications

Bloodstream infection in paediatric cancer centres—leukaemia and relapsed malignancies are independent risk factors

Bloodstream infection in paediatric cancer centres—leukaemia and relapsed malignancies are independent risk factors

Effectiveness of bacterial infection-related cytokine profile (BIRCP) determination for monitoring pathogen infections in children with hemopathy in the bone marrow inhibition phase

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