Antimicrobial Terpenoids from the Oleoresin of the Peruvian Medicinal Plant<i>Copaifera paupera</i>

Tincusi, Benigna M.; Jiménez, Ignacio A.; Bazzocchi, Isabel L.; Moujir, Laila; Mamani, Zulma A.; Barroso, José P.; Ravelo, Ángel G.; Hernández, Basilio V.

doi:10.1055/s-2002-34399

Cited by 80 publications

(62 citation statements)

References 18 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The oleoresin is a natural solution of diterpene acids in an essential oil composed mainly of sesquiterpenes and has been reported as being bactericidal (Maruzzela and Sicurella, 1960;Opdyke, 1976;Tincusi et al, 2002), antihelminthic (Pellegrino, 1967;Gilbert et al, 1972), analgesic (Fernandes and Pereira, 1989), anti-inflammatory (Basile et al, 1988;Fernandes et al, 1992;Veiga-Junior et al, 2001) and gastro-protective (Paiva et al, 1998) as well as showing antitumor (Ohsaki et al, 1994;Lima et al, 1998) and trypanocidal activity. However, in several of these evaluations commercial copaiba oleoresins were used, the chemical composition of which was either not given or only partially described.…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

et al. 2005

View full text Add to dashboard Cite

We characterized the chemical constituents of Copaifera duckei oleoresin and used dermal application to Wistar rats to evaluated its possible mutagenic and cytotoxic activities on peripheral blood reticulocytes and bone marrow cells. Chemical characterization of the oleoresin revealed the presence of sesquiterpene hydrocarbons, an unidentified neutral diterpene and diterpene acids. To evaluate mutagenicity evaluation the rats were treated with 10, 25 and 50% of the LD 50 dose of the oleoresin for three consecutive days and peripheral blood collected after 0, 24, 48 and 72 h for micronucleus analysis. The rats were humanly sacrificed 24 hours after the last treatment and chromosome preparations made using standard techniques. At the three concentrations and the three time intervals tested we found that there were no statistically significant differences in either the mean number of micronucleated reticulocytes (MNRETs) or the number of chromosomal aberrations as to the negative control. However, at 25 and 50% of the LD 50 dose of the oleoresin there was a significant decrease in the mitotic index (MI) as compared to the negative control. Under our experimental conditions, C. duckei V11 oleoresin produced no mutagenic effects on bone marrow cells or in peripheral reticulocytes as assessed by chromosome aberrations and the micronucleus test respectively, but showed cytotoxic activity at high doses.

show abstract

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Além disso, existem diversas pesquisas sobre a atividade antiinflamatória (CARVALHO et al, 2005;VEIGA et al, 2001), analgésica (CARVALHO et al, 2005), antibacteriana (CASCON et al, 2000;TINCUSI, JIMÉNEZ, BAZZOCCHI, 2002); anti-úlcera gástrica (PAIVA et al, 1998) e cicatrizante (PAIVA et al, 2002) do óleo de copaíba.…”

Section: Copaíbaunclassified

Desenvolvimento e avaliação de nanoemulsões com óleos de Carapa guianensis e Copaifera sp. e estudo da ação repelente frente a Aedes aegypti.

Oliveira¹

View full text Add to dashboard Cite

“…Anti-inflamatório (VEIGA JÚNIOR; PATITUCCI; PINTO, 1997); anticancerígeno ; antimicrobiano (TINCUSI et al, 2002), antinociceptivo (GOMES et al, 2007), antiparasitário (SANTOS et al, 2008) Fonte: Autores Quadro 9 -Informações toxicológicas e efeitos comprovados de Momordica charantia (melão-de-são-caetano).…”

Section: Efeitos Comprovadosunclassified

Toxicidade dos fitoterápicos de interesse do SUS: uma revisão

Fernandes

Félix

Nobre

2016

Semin. Cienc. Biol. Saude

View full text Add to dashboard Cite

No Brasil, desde sua colonização até os dias atuais são utilizados produtos de origem natural e a Agência nacional de Vigilância Epidemiológica vem instituindo regras para a regulamentação dos medicamentos fitoterápicos, sendo que foram escolhidas 71 plantas utilizadas empiricamente no país para pesquisa e comprovação de suas propriedades medicinais. Atualmente, 12 dessas 71 plantas foram liberadas para uso no Sistema Único de Saúde, sendo que as outras 59 plantas ainda necessitam de mais pesquisas para liberação do seu uso. Neste contexto, observou-se a necessidade de uma revisão dos testes toxicológicos das plantas que ainda não foram liberadas, na tentativa de impulsar e estimular novas pesquisas nesse campo. Para escolha das plantas foram utilizadas as palavras-chave: nome da planta + toxicidade/ estudos toxicológicos nas línguas português e inglês nos principais bancos de dados. As 10 plantas que apresentaram maior quantidade de estudos toxicológicos foram utilizadas para a pesquisa. Para as dez plantas avaliadas, três apresentam dados completos referentes aos estudos toxicológicos exigidos pela Agência nacional de Vigilância Epidemiológica. Destas, sugere-se que duas (Curcuma longa e Zingiber officinale) sejam adotadas pelo Sistema Único de Saúde. De maneira geral, três plantas já apresentam o valor determinado para DL50, nove plantas apresentam resultados para a toxicidade reprodutiva e cinco plantas, até o presente momento, não apresentam sinais de toxicidade nos testes aplicados.In Brazil, ever since colonization plants have been used as natural products; thus, the National Health Surveillance Agency has been establishing rules for herbal medicine regulation; in this light, 71 plant species were chosen and empirically used in the country to investigate their medicinal properties. Currently, 12 of these 71 plants have been approved to be used in SUS (Public Health System), the remaining species still need further research. Thusly, this review aimed to seek information from toxicological studies on the plants that have not yet been officially approved, to stimulate new research in the field, promoting an economical and functional impact. In order to obtain the information, the keywords plant name + toxicity and/or toxicological studies were searched in the most prominent databases, both in English and in Portuguese. The ten plants with the most references were included in this review. Among the ten plants assessed, three have all the required studies required by the National Health Surveillance Agency, two of which we recommend the immediate adoption by SUS. In general, three plants have a determined LD50, nine have reproductive toxicity data, and five have not yet shown any sign of toxicity. ResumoPalvras-chave: Plantas medicinais. Fitoterapia. Efeitos tóxicos.

show abstract

Antimicrobial Terpenoids from the Oleoresin of the Peruvian Medicinal PlantCopaifera paupera

Cited by 80 publications

References 18 publications

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

In vivo evaluation of the mutagenic potential and phytochemical characterization of oleoresin from Copaifera duckei Dwyer

Desenvolvimento e avaliação de nanoemulsões com óleos de Carapa guianensis e Copaifera sp. e estudo da ação repelente frente a Aedes aegypti.

Toxicidade dos fitoterápicos de interesse do SUS: uma revisão

Contact Info

Product

Resources

About