Antimicrobial Susceptibility Profiles of Salmonella enterica Serovar Typhi Isolates from Patients Attending Health Care Facilities, Ebonyi Sate, Nigeria

Olugbue, V; Nwaugo, V. O.; Okata, M; Oko, I; Okoro, N

doi:10.9734/jamb/2018/39802

Cited by 1 publication

(1 citation statement)

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“…An author reported each colistin resistant Salmonella gastroenteritis [65] and colistin resistant-Salmonella bacteraemia [37]. This study revealed that Salmonellaassociated bacteraemia and Salmonella-associated gastroenteritis mostly developed resistant to three cephalosporin antibiotics: ceftriaxone [22,24,35], cefotaxime [12,33] and cefuroxime [18,45,47,56,60].…”

Section: Reports On Antimicrobial Resistancementioning

confidence: 99%

A systemic review of literatures on human Salmonella enterica serovars in Nigeria (1999-2018)

Akinyemi

Ajoseh

Fakorede

2021

J Infect Dev Ctries

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Introduction: Salmonella infections are endemic in Nigeria. There is lack of reliable data on culture-positive Salmonella with national coverage. This systemic review of literatures was undertaken to aggregate data on culture proven cases of human Salmonellae and to determine the prevailing serotypes for disease burden estimations. Methodology: This involved comprehensive search engines of Pubmed, Google Scholar, Google and Embase for the literatures on culture positive human Salmonellae from 1999-2018. This review documented the prevalence, common Salmonella serotypes. antibiotic resistance and risk factors associated with human Salmonella infections. Results: This study revealed that 21out of 36 States in Nigeria reported Salmonella-associated diseases, spanning the six geopolitical zones. Our study revealed prevalence of 1.9% (2,732/143,756) Salmonella-bacteraemia and 16.3% (1,967/12,081) Salmonella-associated gastroenteritis. Fifty-three 53 Salmonella serotypes were identified. 39 serotypes were associated with Salmonella-bacteraemia and 31 serotypes with Salmonella-gastroenteritis. Salmonella typhi remains the commonest serotype accounting for 85.2% for Salmonella-bacteraemia and 73.1% Salmonella-gastroenteritis. S. typhimurium (3.8%) was mostly implicated invasive non-typhoidal serotype followed S. enteritidis (2.8%) among others. Human Immunodeficiency Virus-infected individuals, malnutrition was among factors predisposing Salmonella infections. Over 60% of the reported Salmonella isolates developed resistance to two or more of 23 antibiotics recorded, mostly ampicillin, cotrimoxazole, tetracycline and amoxicillin. Conclusions: This study revealed 39 Invasive and 31 non-invasive Salmonella serotypes. Ampicillin, cotrimoxazole, amoxicillin-clavulanate and tetracycline are the most frequently reported antibiotics resisted by Salmonella isolates. This antimicrobial resistance exhibited poses a threat to public health. Data generated from this review would serve as a baseline information for future surveillance studies.

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