Antimicrobial susceptibility profile of community-acquired urinary tract infection in adults: A seven months prospective cross-sectional study in Dakar Town, Senegal

Barry, Misbaou; Diallo, Boubacar Alpha; Kante, Daouda; Diallo, I

doi:10.1016/j.afju.2016.11.005

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…Similarly, a higher prevalence of community acquired urinary tract infections (39.1%) was reported in Uganda [ 3 ]. However, our prevalence matches the prevalence of 26.7% observed in a study in Senegal [ 15 ]. These variations could be attributable to differences in antibiotic usage, age, and gender, as well as in the handling and processing of urine samples [ 16 ].…”

Section: Discussionsupporting

confidence: 91%

“…Notably, more than one half of isolated uropathogens causing community acquired urinary tract infections were Gram-negative bacteria, of which E. coli was frequently isolated, which is in keeping with community acquired urinary tract infection studies conducted in Tanzania [ 14 ], Uganda [ 3 ], India [ 17 ], and Senegal [ 15 ]. Besides E. coli , Enterococcus spp., S. aureus and K. pneumoniae were the second, third, and fourth most frequent causes of community acquired urinary tract infections in our setting, which is in keeping with findings reported elsewhere [ 18 , 19 ].…”

Section: Discussionsupporting

confidence: 57%

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Multidrug-Resistant Uropathogens Causing Community Acquired Urinary Tract Infections among Patients Attending Health Facilities in Mwanza and Dar es Salaam, Tanzania

et al. 2022

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In low-income countries, the empirical treatment of urinary tract infections (UTIs) without laboratory confirmation is very common, especially in primary health facilities. This scenario often leads to unnecessary and ineffective antibiotic prescriptions, prompting the emergence and spread of antimicrobial resistance. We conducted this study to examine the antibiogram of uropathogens causing community-acquired urinary tract infections among outpatients attending selected health facilities in Tanzania. Method: This was a cross-sectional health centre-based survey conducted for a period of five months, from July to November 2021, in the Mwanza and Dar es Salaam regions in Tanzania. We enrolled consecutively a total of 1327 patients aged between 2 and 96 years with a median [IQR] age of 28 [22–39] from Dar es Salaam (n = 649) and Mwanza (n = 678). Results: Significant bacteriuria was observed in 364 (27.4% [95%CI: 25.0–29.9]) patients, from whom 412 urinary pathogens were isolated. Gram-negative bacteria contributed to 57.8% (238) of the 412 uropathogens isolated, of which 221 were Enterobacterales, and Escherichia coli was the most frequent. Staphylococcus aureus and Staphylococcus haemolyticus were the most frequently isolated among Gram-positive uropathogens (n = 156). Generally, resistance among Escherichia coli ranged from 0.7% (meropenem) to 86.0% (ampicillin) and from 0.0% (meropenem) to 75.6% (ampicillin) in other Enterobacterales. Moreover, about 45.4% (108) of Enterobacterales and 22.4% (35) of Gram-positive bacteria were multidrug resistant (MDR), p = 0.008. We observed 33 MDR patterns among Gram-negative bacteria, predominantly AMP-CIP-TCY (23/108; 21.3%), and 10 MDR patterns among Gram-positive bacteria, most commonly CIP-GEN-TCY (22/35; 62.9%). Conclusion: the presence of a high number of wide-ranging uropathogens that are multidrug resistant to a variety of antibiotics points to the need to strengthen the laboratory diagnostic systems for the regular surveillance of the antimicrobial resistance of uropathogens to guide and update empirical treatment guidelines.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 57%

Multidrug-Resistant Uropathogens Causing Community Acquired Urinary Tract Infections among Patients Attending Health Facilities in Mwanza and Dar es Salaam, Tanzania

et al. 2022

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“…16 Patients may not report on self-treatment at clinic presentation due to social desirability bias. Prior antimicrobial use was similar to that reported by patients from Senegal, 17 which had a culture positivity of 27% but lower than that in studies from the USA. 18 This suggests that asking patients about antimicrobials may not be sufficient in determining prior exposure as shown in findings from Ghana.…”

Section: Discussionsupporting

confidence: 72%

Sexually transmitted infections and prior antibiotic use as important causes for negative urine cultures among adults presenting with urinary tract infection symptoms to primary care clinics in Zimbabwe: a cross-sectional study

et al. 2021

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ObjectiveUrinary tract infections (UTIs) are common in primary care. The yield of urine cultures in patients with UTI symptoms can be considerably different between high-income and low-income settings. This study aimed to explore possible causes of negative urine cultures in patients presenting with symptoms of UTI to primary health clinics in Harare.DesignCross-sectional study.SettingNine primary health clinics in Harare, Zimbabwe.ParticipantsAdults presenting with symptoms of UTIs between March and July 2020.Primary outcome measuresUrine samples underwent dipstick testing, microscopy, culture, and testing for sexually transmitted infections (STIs) using GeneXpert and for the presence of antibiotic residues using an antibiotic bioassay. The primary outcomes were the number and proportion of participants with evidence of STIs, prior antibiotic exposure, leucocyturia and UTIs.ResultsThe study included 425 participants with a median age of 37.3 years, of whom 275 (64.7%) were women. Leucocyturia was detected in 130 (30.6%, 95% CI 26.2% to 35.2%) participants, and 96 (22.6%, 95% CI 18.7% to 26.9%) had a positive urine culture for a uropathogen. Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis were detected in 43/425 (10.1%, 95% CI 7.4% to 13.4%), 37/425 (8.7%, 95% CI 6.2% to 11.8%) and 14/175 (8.0%, 95% CI 4.4% to 13.1%) participants, respectively. Overall, 89 (20.9%, 95% CI 17.2% to 25.1%) participants reported either having taken prior antibiotics or having had a positive urine bioassay. In 170 (40.0%, 95% CI 35.3% to 44.8%) participants, all of the tests that were performed were negative.ConclusionsThis study found a high prevalence of STIs and evidence of prior antimicrobial use as possible explanations for the low proportion of positive urine cultures.

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“…This relatively low proportion of participants with UTI was probably due to the fact that there are different nonbacterial conditions that can manifest with UTI like symptoms. Our study prevalence correlates with the findings from different studies which include; in Uganda by (14) with a prevalence of (27%), (A Agrawal et al 2017) in India with a prevalence of (29.4%), in Senegal by (15) with a prevalence of (26.7%), in India by (16) with a prevalence of (29.44%) and in West Bengal, India by (17) with a prevalence of (27.75%).…”

Section: Discussionsupporting

confidence: 90%

Prevalence of Extended Spectrum Beta-Lactamase Producing Bacteria (ESBL) in Patients presenting with Urinary Tract Infections (UTIs) at a peri-Urban hospital, Uganda

Abubakar

Josserine²,

Peruth

et al. 2020

Preprint

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Introduction Urinary tract infections remain one of the infections that are commonly diagnosed in Uganda with Enterobacteriaceae reported as the commonest uropathogens. Extended Spectrum Beta Lactamase producing Enterobacteriaceae have emerged as significant pathogens responsible for most of these urinary tract infections throughout the world. This resistance often leads to therapeutic failures from multidrug resistant bacteria. This study was carried out to determine the prevalence of Extended Spectrum Beta-Lactamase producing bacteria (ESBLs) in patients presenting with Urinary Tract Infections (UTIs) at Mbarara MunicipalCouncil Health Center IV, an urban hospital in Mbarara district, south western Uganda.Methods This was a Cross sectional study in which a total of 158 non repetitive midstream urine samples were obtained from 158 participants during months of June to August, 2018. Samples were cultured on conventional media (MacConkey agar and Cysteine Lysine Electrolyte Deficient agar) using a standard wire loop of capacity 0.05ml, incubated at 37 0 C for 24hrs. Only samples that showed significant growth (growth of pure colonies ≥105 cfu/ml) on primary culture were considered for further testing. The isolates were identified basing on the colony appearance, Gram stain and different conventional biochemical tests. Phenotypic expression of ESBLs production was detected using the double disc synergy test using Amoxicillin, Ceftazidime, Amoxicillin-Clavulanic acid and Ceftazidime-Clavulanic acid.Results The results show that 23% of the 158 participants had Urinary Tract infection. The most common uropathogens isolated were Staphylococcus aureus (64%) and Escherichia coli (17%). Phenotypic ESBLs was seen in 27.8% (10/36) of the uropathogens and was commonly seen among Escherichia coli , 60% (6/10) isolates. Others included; Pseudomonas species (8%), Enterobacteraerogenes (1.3%), Citrobacterfruendii (0.6%) and coagulase negative staphylococcus (0.6%).Conclusion This study revealed a fairly high prevalence of ESBL producing organisms in Mbarara Municipal Council Health Center IV and high levels of resistance to third generation cephalosporins.

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Antimicrobial susceptibility profile of community-acquired urinary tract infection in adults: A seven months prospective cross-sectional study in Dakar Town, Senegal

Cited by 10 publications

References 16 publications

Multidrug-Resistant Uropathogens Causing Community Acquired Urinary Tract Infections among Patients Attending Health Facilities in Mwanza and Dar es Salaam, Tanzania

Multidrug-Resistant Uropathogens Causing Community Acquired Urinary Tract Infections among Patients Attending Health Facilities in Mwanza and Dar es Salaam, Tanzania

Sexually transmitted infections and prior antibiotic use as important causes for negative urine cultures among adults presenting with urinary tract infection symptoms to primary care clinics in Zimbabwe: a cross-sectional study

Prevalence of Extended Spectrum Beta-Lactamase Producing Bacteria (ESBL) in Patients presenting with Urinary Tract Infections (UTIs) at a peri-Urban hospital, Uganda

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