Antimicrobial susceptibility patterns of some recently established coryneform bacteria

Abstract

The susceptibility patterns of 480 isolates representing six recently defined species of coryneform bacteria (Corynebacterium amycolatum [n = 101], Corynebacterium auris [n = 48], Corynebacterium glucuronolyticum [n = 86], Brevibacterium casei [n = 50], Dermabacter hominis [n = 49], and Turicella otitidis [n = 146]) to 17 antimicrobial agents were determined by an agar dilution method. Most significantly, for C. amycolatum strains the MICs at which 90% of isolates are inhibited were > or = 32 micrograms/ml for nearly all agents. However, all 480 strains examined were susceptible to glycopeptide antibiotics.

Central Venous Catheter Infection with Brevibacterium sp. in an Immunocompetent Woman: Case Report and Review of the Literature

“…were 0.75 mg/ml and 0.19 mg/l, respectively. Interpretative breakpoints are not available for coryneform bacteria, but our results of decreased susceptibilities to betalactams are in line with the data of Funke et al [3]. We assume from the clinical improvement of our patient that the isolate was susceptible to vancomycin and moxifloxacin.…”

In vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus Corynebacterium

“…Corynebacterium aurimucosum is a recently described species isolated from clinical samples whose clinical role in human pathology remains unknown [14]. All of these species have been reported as susceptible to glycopeptides, linezolid, Q/D and daptomycin, but with variable resistance to other antibiotics [1,4], as observed in our study. A recently published report showed that tigecycline is active against several species of corynebacteria [7], as in our study, therefore this antibiotic could be another potential treatment for infections caused by these organisms.…”

“…More recently, C. amycolatum appeared as one of the commonest species isolated in clinical laboratories, able to cause several nosocomial infections and frequently showing a resistant phenotype against many antibiotics [8]. Together with these species, C. striatum and C. afermentans were also recognised as human pathogens [2,13], showing a variable antibiotic susceptibility phenotype [4]. Corynebacterium coyleae is a new species of corynebacteria that has been recently described as a human pathogen, phenotypically similar to C. jeikeium, which appears to be usually macrolide-resistant [9].…”

“…These organisms have been described as the cause of a wide range of human infections, including severe foreign-body-related infections such as endocarditis and prosthetic joint infections [2,3]. Many of these organisms appear in vitro to be resistant to most antibiotics, with only a limited number of antibiotics being active [4], therefore therapeutic approaches are limited, especially in the nosocomial setting where multidrug-resistant organisms are common.…”

Urethritis due to Corynebacterium glucuronolyticum

“…Maeda et al [11] found that a single dose of 1 g azithromycin was effective in 32 (84.2%) of 38 men with non-mycoplasmal, non-ureaplasmal NGCU. Funke et al [12] consider that MICs of ciprofloxacin covered a broad range. However, the strain described in this report, in particular, is susceptible to the treatment administrated, ciprofloxacin, as was observed from the benign evolution of the patient.…”