In vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus Corynebacterium

Fernández-Roblas, R.; Adames, H.; Martín-de-Hijas, N.Z.; Almeida, de; Gadea, Ignacio; Esteban, Jaime

doi:10.1016/j.ijantimicag.2008.11.001

Cited by 47 publications

(33 citation statements)

References 15 publications

(26 reference statements)

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“…For all 16 of the strains tested, the tigecycline MICs ranged from 0.5 to 2 mg/liter, consistent with intermediate or resistant phenotypes. This is in contrast to the data presented by Fernandez-Roblas and colleagues, who recommended tigecycline as a good alternative for infections caused by non-C. diphtheriae corynebacteria (7). On the basis of the results presented in this study, we are of the opinion that tigecycline does not represent a good therapeutic option for the treatment of C. tuberculostearicum infections.…”

Section: Discussioncontrasting

confidence: 99%

Corynebacterium tuberculostearicum: a Potentially Misidentified and Multiresistant Corynebacterium Species Isolated from Clinical Specimens

Hinić

Lang²,

Weisser

et al. 2012

J Clin Microbiol

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c Corynebacterium tuberculostearicum is a lipophilic corynebacterium validly characterized in 2004. We provide clinical information on 18 patients from whom this organism was isolated. The majority of the patients were hospitalized and had a history of prolonged treatment with broad-spectrum antimicrobials. In 7 (38.9%) of the 18 cases, the isolates were found to be clinically relevant. The present report also includes detailed data on the biochemical and molecular identification of C. tuberculostearicum, as well as its identification by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Our data demonstrate that routine biochemical tests do not provide reliable identification of C. tuberculostearicum. MALDI-TOF MS represents a helpful tool for the identification of this species, since all of the strains matched C. tuberculostearicum as the first choice and 58.3% (7/12) of the strains processed with the full extraction protocol generated scores of >2.000. Nevertheless, partial 16S rRNA gene sequencing still represents the gold standard for the identification of this species. Due to the challenging identification of C. tuberculostearicum, we presume that this organism is often misidentified and its clinical relevance is underestimated. The antimicrobial susceptibility profile of C. tuberculostearicum presented here reveals that 14 (87.5%) of the 16 strains analyzed exhibited multidrug resistance.

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Section: Discussioncontrasting

confidence: 99%

Corynebacterium tuberculostearicum: a Potentially Misidentified and Multiresistant Corynebacterium Species Isolated from Clinical Specimens

Hinić

Lang²,

Weisser

et al. 2012

J Clin Microbiol

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“…The conducted study characterizing resistance to antibiotics isolated from clinical material of different species of the genus Corynebacterium (Anderson et al, 2008;Fernandez-Roblas et al, 2009;Funke et al, 1997a;Funke et al, 1997b;Garcia-Bravo et al, 1996;Gomez-Garceset al, 2007;Martinem-Martinez et al, 1995;Otsuka et al, 2006;Roberts et al, 1992, Troxler R et al, 2001, Weiss et al, 1996 draw attention to the most frequently occuring mechanisms of resistance to antibiotics in this group of microorganisms. The results show participation of extrachromosomal genetic elements in transmission of resistance genes in both pathogenic and potentially pathogenic -opportunistic and typically nonpathogenic ones, e.g.…”

Section: Mechanisms Of Resistance To Antibiotics Most Commonly Occurrmentioning

confidence: 99%

“…An analysis of sensistivity to antibiotics of a large group of strains of C. urealyticum, C. amycolatum, C. jeikeium, C. coyleae, C. striatum, C. aurimucosum and C. afermentans was conducted with assays using Etests (Fernandez-Roblas et al, 2009). The authors found that strains of all tested species were susceptible to glycopeptides, linezolid, chinupristin/dalphopristin and daptomycin, which was also confirmed in other studies (Funke et al, 1997a;Funke et al, 1997b).…”

Section: Antibiotic Therapy Used In Infections Of Corynebacterium Sppmentioning

confidence: 99%

“…In recent years we can observe an increasing number of publications describing different incidents of infections, where species of Corynebacterium are isolated as the etiological factor of infection (Anderson et al, 2008;Campanile et al, 2009;Chiner et al, 1999;Dela et al, 2008;Fernandez-Roblas et al, 2009;Funke et al, 1997a;Funke et al, 1997b;Lagrou et al, 1998;Otsuka et al, 2005;Ostuka et al, 2006;Williams et al, 1993). It is a large and very diverse group of microorganisms, in which Corynebacterium diphtheriae is the most important species, with the most important human-pathogenic significance (Gomes et al, 2009;Wagner et al, 2011;Wilson, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of Antibiotic Resistance in Corynebacterium spp. Causing Infections in People

Olender¹

2012

Antibiotic Resistant Bacteria - A Continuous Challenge in the New Millennium

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“…La terapia combinada usando un macrólido (claritromicina tiene mejor actividad contra M. abscessus o M. chelonae) 9,25 o quinolonas (especialmente para M. fortuitum) 9,25 y un antimicrobiano parenteral (amikacina) mostró una actividad uniforme contra estos microorganismos, siendo la acción de cefoxitina e imipenem menos predecible 9,25 , pero recomendada para las infecciones graves.…”

Section: Discussionunclassified

Infección protésica mamaria por Mycobacteriumfortuitum en una paciente con lupus eritematoso sistémico

Lizaso¹,

Garcı́a²,

Aguirre³

et al. 2011

Rev. chil. infectol.

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Breast implant infection by Mycobacterium fortuitum in a patient with systemic lupus erythematosusIn recent decades there has been an increase in the number of breast implants for reconstruction and cosmetic purposes. Infection is a severe complication mostly caused by Staphylococcus aureus or coagulase-negative staphylococci. Mycobacteria are an infrequent cause of infection in this type of surgery. We describe a case of Mycobacterium fortuitum infection in a patient with lupus, subjected to a prosthetic replacement. These patients are more prone to unusual opportunistic infections. Treatment always requires both removal of prosthetic material and antibiotic therapy.Key words: Breast implants; atypical mycobacterial infection; systemic lupus erythematosus; Mycobacterium fortuitum.Palabras clave: Implantes mamarios, infecciones por micobacterias atípicas, Mycobacterium fortuitum. Caso clínicoP aciente con 50 años de edad, con diagnóstico de lupus eritematoso sistémico (LES) hacía cuatro años. Durante su evolución presentó como intercurrencia un síndrome antifosfolipídico y nefritis lúpica que requirió tratamiento con anticoagulantes orales, azatioprina 100 mg/día, hidroxicloroquina 200 mg/día y prednisona 20 mg/día en dosis decreciente. En el año 1996 se le practicó una mastectomía bilateral por antecedentes familiares directos de neoplasia mamaria y hallazgos mamográfi cos de micro-calcifi caciones agrupadas en ambas mamas. Con diagnóstico histopatológico de displasia severa se procedió a la colocación de prótesis mamarias texturizadas por vía submuscular. En agosto de 2008 fue sometida a un recambio protésico mamario bilateral, por encapsulamiento y retracción cutánea, colocándose prótesis texturizadas por vía retromuscular con incisión inframamaria. Al mes del procedimiento, comenzó con equivalentes febriles, tumefacción y eritema en ambas mamas. Se realizó una ecografía de tejidos blandos que demostró una colección periprotésica derecha evidente y mínima contralateral. Se le indicó reposo, hielo y anti-infl amatorios. Luego de una mejoría transitoria recrudeció el cuadro por lo que se le prescribió amoxicilina/ác. clavulánico (3 gr/ día) que luego fue modifi cado a ciprofl oxacina asociada a clindamicina. Posteriormente, consultó a un médico infectólogo quien le aconsejó retiro de ambas prótesis mamarias dado el hallazgo ecográfi co de colecciones bilaterales; sin embargo, la paciente no accedió. Evolucionó posteriormente con drenaje espontáneo de secreción en la mama derecha, por lo que se realizó una evacuación quirúrgica, obteniéndose un líquido de aspecto citrino que se envió a cultivo (Figuras 1 y 2).

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In vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus Corynebacterium

Cited by 47 publications

References 15 publications

Corynebacterium tuberculostearicum: a Potentially Misidentified and Multiresistant Corynebacterium Species Isolated from Clinical Specimens

Corynebacterium tuberculostearicum: a Potentially Misidentified and Multiresistant Corynebacterium Species Isolated from Clinical Specimens

Mechanisms of Antibiotic Resistance in Corynebacterium spp. Causing Infections in People

Infección protésica mamaria por Mycobacteriumfortuitum en una paciente con lupus eritematoso sistémico

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