Antimicrobial susceptibility patterns of gonococcal isolates in Pretoria, South Africa, over a 20-year period (1984-2004)

Dangor, Y; Jongh, M. De; Adam, A; Hoosen, Anwar A.

doi:10.1080/10158782.2010.11441393

Cited by 3 publications

(1 citation statement)

References 12 publications

(9 reference statements)

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“…Erythromycin and tetracycline are the recommended drugs for the treatment of chlamydial infections, [33] and most cases of gonorrheae also present with chlamydial coinfection. However, since syndromic diagnosis does not differentiate between gonorrheae and chlamydial infection, patients with gonococcal infections are exposed to this group of drugs, [27,34] because, the national standard protocol for the treatment of chlamydia requires that these drugs are administered for 7 days [35]. This eventually exerts selective pressure on strains of N. gonorrhoeae that leads to mutations in key genes [27,32].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antimicrobial Susceptibility Pattern of Neisseria gonorrhoeae in Kumasi, Ghana

Acheampong

Opoku

Adokoh

et al. 2018

JAMB

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Background: In most African countries, including Ghana, treatment of the Neisseria gonorrhoeae infection is based on syndromic management owing to lack of laboratory equipment and resources in primary care facilities where most patients first visit. Aim: The aim of this study was to determine the prevalence of Neisseria gonorrhoeae and evaluate its susceptibility pattern to standard antimicrobials used for empirical treatment of the infection in patients that attended Ellolab Diagnostic Centre at Kumasi from November 2014 to July 2017. Methodology: Four hundred and twenty-seven (427) clinical specimens from suspected patients were cultured on chocolate agar. Positive cultures were tested for resistance against twelve Original Research Article

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Section: Discussionmentioning

confidence: 99%

Prevalence and Antimicrobial Susceptibility Pattern of Neisseria gonorrhoeae in Kumasi, Ghana

Acheampong

Opoku

Adokoh

et al. 2018

JAMB

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Resistance Profile of Neisseria gonorrhoeae in KwaZulu-Natal, South Africa Questioning the Effect of the Currently Advocated Dual Therapy

et al. 2019

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Background We report on the antimicrobial resistance profile of Neisseria gonorrhoeae isolates and the distribution of tetM genes in isolates with high-level tetracycline resistance in KwaZulu-Natal, South Africa. Methods Male and female patients presenting with urethral and/or vaginal discharge were recruited into the study. Urethral and cervical secretions were cultured on New York City agar. Confirmatory tests for N. gonorrhoeae included Gram stain, catalase, oxidase, and carbohydrate utilization tests. Beta-lactamase was tested by means of the chromogenic cephalosporin test. Minimum inhibitory concentrations were determined using agar dilution with multipoint inoculation. Polymerase chain reaction with gel electrophoresis was used to detect the presence and type of the tetM gene. Results N. gonorrhoeae was isolated from the specimens of 319 (26%) of the 1220 recruited patients. Of these 319 isolates, 71% were resistant to 3 or more drugs. Resistance to azithromycin was found in 68% of the isolates. All isolates showed high-level tetracycline resistance with minimum inhibitory concentration values of 16 and 32 mg/mL. The tetM gene was present in 293 (92%). The American type was found in 264 (90%) and the Dutch type in 29 (10%). Twenty-six (8%) did not carry a tetM gene. Conclusions The current syndromic management with dual ceftriaxone and azithromycin is due to the high level of azithromycin resistance factually single-drug therapy. High-level tetracycline resistance based on a resistance mechanism other than ribosome protection by the tetM gene product is present in N. gonorrhoeae infecting South African patients.

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Antibiotic susceptibility pattern of Neisseria gonorrhoeae strains isolated from five cities in India during 2013–2016

Kulkarni

Bala

Muqeeth

et al. 2018

Journal of Medical Microbiology

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Our data suggest that the disc diffusion method which is both cost effective and more feasible, can effectively be used routinely for monitoring antibiotic susceptibility in N. gonorrhoeae, in limited resource countries like India. We demonstrate the emergence of decreased susceptibility to ceftriaxone and cefixime and threshold levels of resistance to azithromycin in India. This underscores the importance of maintaining continued surveillance for antibiotic resistance in N. gonorrhoeae and a potential requirement for strategic change in guidelines in the not so distant future.

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Antimicrobial susceptibility patterns of gonococcal isolates in Pretoria, South Africa, over a 20-year period (1984-2004)

Cited by 3 publications

References 12 publications

Prevalence and Antimicrobial Susceptibility Pattern of Neisseria gonorrhoeae in Kumasi, Ghana

Prevalence and Antimicrobial Susceptibility Pattern of Neisseria gonorrhoeae in Kumasi, Ghana

Resistance Profile of Neisseria gonorrhoeae in KwaZulu-Natal, South Africa Questioning the Effect of the Currently Advocated Dual Therapy

Antibiotic susceptibility pattern of Neisseria gonorrhoeae strains isolated from five cities in India during 2013–2016

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