Antimicrobial Susceptibility Pattern of Staphylococcus aureus

Dilnessa, Tebelay

doi:10.5772/intechopen.74615

Cited by 2 publications

(3 citation statements)

References 11 publications

(10 reference statements)

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“…It is a preferred antibiotic due to its shorter administration period and frequency [ 29 ]. S. aureus also showed susceptibility to Cotrimoxazole, contrary to what was reported in [ 30 ], where resistance to Cotrimoxazole was evident in MSSA. However, the susceptibility of S. aureus to Vancomycin correlates with the findings of [ 30 ].…”

Section: Discussioncontrasting

confidence: 93%

“…S. aureus also showed susceptibility to Cotrimoxazole, contrary to what was reported in [ 30 ], where resistance to Cotrimoxazole was evident in MSSA. However, the susceptibility of S. aureus to Vancomycin correlates with the findings of [ 30 ]. Staphylococcus saprophyticus was sensitive to all the antibiotics, while S. epidermidis was resistance to Vancomycin and Oxacillin but susceptible to other antibiotics.…”

Section: Discussioncontrasting

confidence: 93%

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Investigating the Toxicity of Compounds Yielded by Staphylococci on Vero Cells

Modimola

Green

Njobeh

et al. 2022

Toxins

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Bacterial secondary metabolites play a major role in the alleviation of diseases; however, the cytotoxicity of other metabolites cannot be ignored as such metabolites could be detrimental to human cells. Three Staphylococci strains Staphylococcus aureus, staphylococcus epidermidis and staphylococcus saprophyticus were used in the experiments. These strains are well known to cause hospital and community-acquired infections. Secondary metabolites from S. aureus isolated from milk of cows with clinical features of mastitis (swollen udders and the production of watery clotted milk), S. saprophyticus (ATCC 35552), and S. epidermidis (ATCC 51625) were exposed to a minimal medium then screened using Gas Chromatography High-Resolution Time-of-flight Mass Spectrometry (GC-HRTOF-MS) and identified with Nuclear Magnetic Resonance (NMR). From S. epidermidis, two compounds were isolated: oleamide and methyl palmitate; three from S. aureus, including fluoranthene, 3-methyl-2-phenyl-1H-pyrrole, and cyclo(L-Leu-L-Propyl); while S. saprophyticus yielded succinic acid, 1,2,6-hexantriol, veratramine, and 4-methyl-pentyl-amine. The secondary metabolites were tested for cytotoxicity using the Vero cell line. Fluoranthene exhibited toxicity with an LC50 of 0.0167 mg/mL to Vero cells, while the other metabolites did not. Methyl palmitate was the least toxic of all of the metabolites. The results imply that none of the compounds, except fluoranthene, pose any danger to human cells.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussioncontrasting

confidence: 93%

Investigating the Toxicity of Compounds Yielded by Staphylococci on Vero Cells

Modimola

Green

Njobeh

et al. 2022

Toxins

View full text Add to dashboard Cite

show abstract

“…Additionally, penicillin-resistant Staphylococcus is discovered in hospitals. And bacteria isolated from the community [1,2]. A Exploration of novel antibacterial active chemicals is required.. Andalas (Morus macroura) is One of the alternatives for an active compound source.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characterization of Bioactive Compounds on Ethanol Extracts Fermentation Products of Isolate BJDTA21 Endophytic Bacterial Andalas

Mardhiyah¹,

Putri²,

Violita³

et al. 2023

Advances in Biological Sciences Research

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The West Sumatra, Indonesia, mascot plant is called Andalas (Morus macroura Miq.). This plant belongs to the Moraceae family, which has a long history of being used medicinally. The goal of this study was to evaluate the Andalas ethanol extract's potential to prevent the growth of pathogenic microorganisms. The Andalas stems and roots were subjected to the ethanol extraction process. A completely randomized design (CRD) was utilized to determine the ideal concentration of ethanol extracts of Andalas roots and stems for suppressing test microorganisms. In this investigation, there were four different extract concentrations used as treatments: 3.12 percent, 6.25 percent, 12.50 percent, and 25 percent. The paper disc diffusion method was used to conduct antimicrobial activity testing on the test microorganisms (Staphylococcus aureus, Escherichia coli, and Candida albicans). The outcomes revealed that the. The extract's potential mechanisms for exerting antibacterial activity against both of the studied microorganisms include flavonoids, alkaloids, saponins, terpenoids, and tannins.

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Antimicrobial Susceptibility Pattern of Staphylococcus aureus

Cited by 2 publications

References 11 publications

Investigating the Toxicity of Compounds Yielded by Staphylococci on Vero Cells

Investigating the Toxicity of Compounds Yielded by Staphylococci on Vero Cells

Phytochemical Characterization of Bioactive Compounds on Ethanol Extracts Fermentation Products of Isolate BJDTA21 Endophytic Bacterial Andalas

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