Antimicrobial Susceptibility of Gram-Negative Nonurinary Bacteria to Fosfomycin and Other Antimicrobials

Samonis, George; Maraki, Sofia; Rafailidis, Petros I.; Kapaskelis, Anastasios; Kastoris, Antonia C.; Falagas, Matthew E.

doi:10.2217/fmb.10.47

Cited by 33 publications

(19 citation statements)

References 21 publications

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“…The occurrence of fosfomycin resistance in E. coli from human and pet animal isolates is still rare in many countries (Ͻ5%) (3,6,7,9,12,13,15,20). However, in this study, a higher prevalence of fosfomycin resistance mainly mediated by FosA3 was observed in E. coli isolates recovered from pets during 2006 and 2010, although none of the pets had received fosfomycin treatment.…”

mentioning

confidence: 47%

“…The recent growing prevalence of extended-spectrum ␤-lactamase (ESBL)-producing Enterobacteriaceae and fluoroquinoloneresistant E. coli has rekindled interest in fosfomycin as a therapeutic agent in many countries (7,8,18). Despite its worldwide use in clinical practice for nearly 4 decades, fosfomycin remains effective against common uropathogens without giving rise to clinically significant resistance (3,6,7,9,12,15,20). The main type of resistance to fosfomycin appears to be chromosome mediated rather than plasmid mediated (17,21,23,27).…”

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confidence: 99%

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Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M β-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China

Hou

Huang

Deng

et al. 2012

Antimicrob Agents Chemother

131

134

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The presence and characterization of plasmid-mediated fosfomycin resistance determinants among Escherichia coli isolates collected from pets in China between 2006 and 2010 were investigated. Twenty-nine isolates (9.0%) were positive for fosA3, and all of them were CTX-M producers. The fosA3 genes were flanked by IS26 and were localized on F2:A؊:B؊ plasmids or on very similar F33:A؊:B؊ plasmids carrying both bla CTX-M-65 and rmtB. These findings indicate that the fosA3 gene may be coselected by antimicrobials other than fosfomycin.

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confidence: 47%

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confidence: 99%

Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M β-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China

Hou

Huang

Deng

et al. 2012

Antimicrob Agents Chemother

131

134

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“…More promising data have been reported for CR P. aeruginosa strains; three studies reported synergy between fosfomycin and colistin (22%) or carbapenems (up to 40%) against clinical isolates using checkerboards and time-kill assays (40,149,150). Using checkerboards/FICI, aminoglycosides, piperacillin-tazobactam, ceftazidime, cefepime, and ciprofloxacin were also synergistic with fosfomycin against CR P. aeruginosa strains (151).…”

Section: Newer Studiesmentioning

confidence: 94%

“…The laboratory methods that have been used for the determination of in vitro susceptibility of Gram-positive and Gram-negative pathogens to fosfomycin include agar (Mueller-Hinton agar) dilution, broth dilution, disk diffusion, and Etest techniques (22,40,(56)(57)(58)(59). Supplementation of agar or broth with G-6-P enhances fosfomycin activity.…”

Section: Susceptibility Testing Methodologymentioning

confidence: 99%

“…(including Enterococcus faecalis and E. faecium irrespective of vancomycin resistance), Staphylococcus aureus (irrespective of methicillin resistance), and S. epidermidis (37,38). Fosfomycin also exhibits considerable activity against Gram-negative pathogens, including Salmonella spp., Shigella spp., E. coli, Klebsiella and Enterobacter spp., Serratia spp., Citrobacter spp., and Proteus mirabilis (37)(38)(39)(40)(41). Fosfomycin has been also found to be active against Listeria monocytogenes, Neisseria gonorrhoeae, Aerococcus urinae, and Helicobacter pylori (42)(43)(44)(45).…”

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confidence: 99%

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Fosfomycin

et al. 2016

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SUMMARYThe treatment of bacterial infections suffers from two major problems: spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) pathogens and lack of development of new antibiotics active against such MDR and XDR bacteria. As a result, physicians have turned to older antibiotics, such as polymyxins, tetracyclines, and aminoglycosides. Lately, due to development of resistance to these agents, fosfomycin has gained attention, as it has remained active against both Gram-positive and Gram-negative MDR and XDR bacteria. New data of higher quality have become available, and several issues were clarified further. In this review, we summarize the available fosfomycin data regarding pharmacokinetic and pharmacodynamic properties, thein vitroactivity against susceptible and antibiotic-resistant bacteria, mechanisms of resistance and development of resistance during treatment, synergy and antagonism with other antibiotics, clinical effectiveness, and adverse events. Issues that need to be studied further are also discussed.

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Serratia infections in a general hospital: characteristics and outcomes

Samonis

Vouloumanou

Christofaki

et al. 2011

Eur J Clin Microbiol Infect Dis

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We aimed to present our experience regarding infections caused by Serratia spp. in a region with relatively high antimicrobial resistance rates. We retrospectively reviewed the databases of the microbiological laboratory of the University Hospital of Heraklion, Crete (2/2004-12/2009). A total of 77 patients [67.5% men, mean age ± standard deviation (SD) = 56.9 ± 24.5 years) were identified; 37.7% were outpatients. Sixty-five (84.4%) of the 77 included patients had a Serratia marcescens isolate; the remaining 12 patients had a non-marcescens Serratia spp. The most frequently observed infections were respiratory tract infection (32.5%) and keratitis/endophthalmitis (20.8%). Seventy-three (94.9%) patients were cured. Four deaths were observed; three of them were considered as attributed to the Serratia infection. No difference was found regarding the characteristics and outcomes between patients with Serratia marcescens and non-marcescens infections. In addition, antipseudomonal penicillins and their combinations with beta-lactamase inhibitors, as well as carbapenemes, and fluoroquinolones exhibited high antimicrobial activity against both the tested Serratia marcescens and non-marcescens isolates. Our study adds useful information regarding the characteristics and outcomes of patients with Serratia infection, as well as the susceptibilities of the respective Serratia marcescens and non-marcescens isolates, in a region with relatively high levels of antimicrobial resistance.

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Antimicrobial Susceptibility of Gram-Negative Nonurinary Bacteria to Fosfomycin and Other Antimicrobials

Abstract: In a region with relatively high levels of antimicrobial resistance, fosfomycin seems to exhibit good levels of in vitro activity against Gram-negative nonurinary isolates. These data justify further evaluation of its potential clinical effectiveness.

Cited by 33 publications

References 21 publications

Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M β-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China

Dissemination of the Fosfomycin Resistance Gene fosA3 with CTX-M β-Lactamase Genes and rmtB Carried on IncFII Plasmids among Escherichia coli Isolates from Pets in China

Fosfomycin

Serratia infections in a general hospital: characteristics and outcomes

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