Antimicrobial susceptibility monitoring of mastitis pathogens isolated from acute cases of clinical mastitis in dairy cows across Europe: VetPath results

Thomas, Valérie; Jong, Anno de; Moyaert, Hilde; Simjee, Shabbir; Garch, Farid El; Morrissey, Ian; Marion, Hervé; Vallé, Michel

doi:10.1016/j.ijantimicag.2015.03.013

Cited by 72 publications

(89 citation statements)

References 20 publications

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“…In this same study, the authors reported lower levels of resistance to tetracycline (7.2%) than ours (18.1%); this may also be due to differences in breakpoints used and a heterogeneous spatial distribution of AMR in mastitis, potentially linked to a heterogeneous spatial distribution of practices and farm management. Recently, a European study performed on 282 S. uberis isolates from dairy cattle with clinical mastitis found results similar to ours for erythromycin resistance (20.0%), but they identified higher resistance to tetracycline (28.7% using the CLSI breakpoint; Thomas et al, 2015).…”

Section: Antimicrobial Resistance In Bacteria Involved In Mastitissupporting

confidence: 82%

“…Because the use of antibiotics can lead to resistance (Aarestrup, 2015), AMR occurrence must be carefully monitored to guide prudent prescription (Thomas et al, 2015). Hundreds of publications describe the proportion of AMR in bovine mastitis pathogens in the last decades (Barlow, 2011), highlighting differences in AMR proportions between areas and populations (Erskine et al, 2002;Makovec and Ruegg, 2003;Pitkälä et al, 2004;Osterås et al, 2006;Tenhagen et al, 2006;Botrel et al, 2010;Idriss et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial resistance in bacteria isolated from mastitis in dairy cattle in France, 2006–2016

Boireau¹,

Cazeau

Jarrige

et al. 2018

Journal of Dairy Science

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In dairy cattle, mastitis is the most frequent bacterial disease, and the routine use of antibiotics for treatment and prevention can drive antimicrobial resistance (AMR). The aim of our study was to estimate the levels of AMR of the 3 main bacteria isolated from dairy cattle with mastitis in France (Streptococcus uberis, Escherichia coli, and coagulase-positive staphylococci) and to investigate their changes over time. Data collected between 2006 and 2016 by the French surveillance network for AMR in pathogenic bacteria of animal origin (called RESAPATH) were analyzed. The proportions of mono- and multidrug resistance were calculated and the trends were investigated using nonlinear analyses applied to time series. Over the whole period, the lowest proportions of resistance in S. uberis isolates were observed for oxacillin (2.2%) and gentamicin (2.4%) and most resistance levels were below 20%. The trends in resistance showed some significant variation, mainly for S. uberis, but without a common pattern across the various antibiotics examined. For only 2 combinations of bacteria-antibiotic the trend in resistance showed a continuous increase from 2006 to 2016: tetracycline resistance in S. uberis isolates and third-generation cephalosporin resistance in E. coli isolates. In E. coli, the highest proportions of resistance were observed for amoxicillin (28.1%) and tetracycline (23.1%). Resistance to third-generation cephalosporins in E. coli from dairy cattle was almost nil in 2006, but reached 2.4% in December 2016. This increase is particularly concerning because these antibiotics constitute one of the latest therapeutic alternatives to fight severe infectious diseases in humans. Except for penicillin (33.9%), the proportions of resistance in coagulase-positive staphylococci were below 11% during the whole study period. Multidrug resistance (isolates with acquired resistance to at least one antibiotic in 3 or more antibiotic classes) ranged from 2.4% for coagulase-positive staphylococci to 9.9% for S. uberis. These findings can serve as guidelines for practitioners in the choice of the most appropriate antibiotic according to the prevailing epidemiological context. Ultimately, our results contribute to risk assessment of AMR and provide a baseline for setting up and evaluating control measures and designing strategies to limit AMR.

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Section: Antimicrobial Resistance In Bacteria Involved In Mastitissupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Antimicrobial resistance in bacteria isolated from mastitis in dairy cattle in France, 2006–2016

Boireau¹,

Cazeau

Jarrige

et al. 2018

Journal of Dairy Science

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“…Compared with 8 European countries (Thomas et al, 2015), resistance rates were higher in our Chinese study. We found major differences in antimicrobial consumption patterns among countries (Mather et al, 2011), reflecting a combination of factors including national guidelines for proper antimicrobial use, veterinarian prescription patterns, pharmaceutical marketing strategies, animal demographics, and specific needs for antimicrobials in specific countries (ESVAC, 2012).…”

Section: Discussioncontrasting

confidence: 63%

Antimicrobial resistance profiles of 5 common bovine mastitis pathogens in large Chinese dairy herds

Cheng

Barkema

et al. 2019

Journal of Dairy Science

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The prevalence of antimicrobial resistance (AMR) is increasing in human and animal pathogens, becoming a concern worldwide. However, prevalence and characteristics of AMR of bovine mastitis pathogens in large Chinese dairy herds are still unclear. Therefore, our objective was to determine the AMR profile of bacteria isolated from clinical mastitis in large (>500 cows) Chinese dairy herds. A total of 541 isolates of the 5 most common species, Staphylococcus aureus (n = 103), non-aureus staphylococci (NAS; n = 107), Streptococcus species (n = 101), Klebsiella species (n = 130), and Escherichia coli (n = 100), isolated from bovine clinical mastitis on 45 dairy farms located in 10 provinces of China were included. Presence of AMR was determined by minimum inhibitory concentrations using the microdilution method. Prevalence of multidrug resistance (resistance to >2 antimicrobials) was 27% (148/541). A very wide distribution of minimum inhibitory concentrations was screened in all isolates, including Staph. aureus isolates, which were resistant to penicillin (66%). In addition, NAS (30%) were more resistant than Staph. aureus to oxacillin (84%), penicillin (62%), tetracycline (34%), and clindamycin (33%). Prevalence of resistance to tetracycline was high (59%) in Streptococcus spp. Additionally, prevalence of resistance of both E. coli and Klebsiella spp. was high to amoxicillin/clavulanate potassium (81 and 38%, respectively), followed by tetracycline (only Klebsiella spp. 32%). A high proportion (27%) of isolates were multidrug resistant; the most frequent combinations were clindamycin-cefalexin-tetracycline or enrofloxacin-cefalexin-penicillin patterns for Staph. aureus; enrofloxacin-oxacillin-penicillin-tetracycline patterns for NAS; clindamycin-enrofloxacin-tetracycline patterns for Streptococcus spp.; amoxicillin/clavulanate potassiumceftiofur-polymyxin B patterns for Klebsiella spp.; and amoxicillin/clavulanate potassium-ceftiofur-polymyxin B patterns for E. coli. Resistance for 4 kinds of antimicrobials highly critical for human medicine, including daptomycin, vancomycin, imipenem, and polymyxin B, ranged from 0 to 24%. In conclusion, prevalence of AMR in mastitis pathogens was high on large Chinese dairy farms, potentially jeopardizing both antimicrobial efficacy and public health. Results of this study highlighted the need for improvements in antimicrobial stewardship and infection control programs in large Chinese dairy farms to reduce emergence of AMR.

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“…Therefore, it can be speculated that the E. coli strains showed a high resistance to amoxicillin. Resistance rates towards tetracycline were 9.0% in the European Union (Thomas et al, 2015), 14.3% in Canada (Saini et al, 2012), and 55.1% in Southwestern Nigeria (Adesoji, Ogunjobi, Olatoye, & Douglas, 2015). Moreover, 34.8% isolates had MDR (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility, phylotypes, and virulence genes of Escherichia coli from clinical bovine mastitis in five provinces of China

Lan

Liu

Meng

et al. 2020

Food and Agricultural Immunology

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The objectives of this study were to determine the antimicrobial susceptibility, phylotype, and virulence genes of Escherichia coli (E. coli) from cows with clinical mastitis. A total of 497 mastitis samples were collected and 92 E. coli isolates were identified. E. coli isolates were highly resistance to ampicillin (41.3%), followed by piperacillin (36.9%) and tetracycline (34.7%). Five intimin types, namely μR-ι2, λ, ξR/β2, νR-ε2, η, were observed among 75 EPEC strains with eae gene, with all the intimins were first detected in bovine mastitis milk. And 65 E. coli strains (70.7%) belonged to seven different O serotypes (O121, O91, O22, O26, O128, O111, and O113). For the phylogroup assignment, only 87 E. coli isolates could be assigned into phylogroup B1, A, C, and E. This study suggested the prevailing among EPEC strains isolated from mastitis in five provinces was important to understand the etiology of E. coli.

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Antimicrobial susceptibility monitoring of mastitis pathogens isolated from acute cases of clinical mastitis in dairy cows across Europe: VetPath results

Cited by 72 publications

References 20 publications

Antimicrobial resistance in bacteria isolated from mastitis in dairy cattle in France, 2006–2016

Antimicrobial resistance in bacteria isolated from mastitis in dairy cattle in France, 2006–2016

Antimicrobial resistance profiles of 5 common bovine mastitis pathogens in large Chinese dairy herds

Antimicrobial susceptibility, phylotypes, and virulence genes of Escherichia coli from clinical bovine mastitis in five provinces of China

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