Antimicrobial susceptibility and molecular subtyping of 55 Turkish Bacillus anthracis strains using 25-loci multiple-locus VNTR analysis

Ortatatli, Mesut; Karagöz, Alper; Perçin, Duygu; Kenar, Levent; Kılıç, Selçuk; Durmaz, Rıza

doi:10.1016/j.cimid.2012.02.005

Cited by 21 publications

(25 citation statements)

References 33 publications

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“…Moderately sensitive strains appeared in several studies (Cavallo et al, 2002;Mohammed et al, 2002;Luna et al, 2007;Ortatatli et al, 2012), andActa Veterinaria Hungarica 64, 2016 two resistant strains were described in Turkey (Ortatatli et al, 2012). In the current study, 17.2% of the Hungarian strains were only intermediately sensitive to erythromycin.…”

Section: Discussionmentioning

confidence: 63%

“…Most B. anthracis stains are resistant or intermediately susceptible to cefotaxime according to previous findings (Doğonay and Aydin, 1991;Odendaal et al, 1991;Turnbull et al, 2004;Habrun et al, 2011;Ortatatli et al, 2012). Turnbull et al (2004) found one susceptible strain (MIC 3 mg/L) with the Etest method, while Doğanay and Aydin (1991) described five susceptible strains with the disc diffusion test.…”

Section: Discussionmentioning

confidence: 95%

“…Ciprofloxacin resistance has not been described yet. Resistance against doxycycline was observed in one strain (MIC 4 mg/L) in Turkey (Ortatatli et al, 2012). All examined strains from Hungary were susceptible to both antibiotics.…”

Section: Discussionmentioning

confidence: 99%

“…Rifampicin, vancomycin and clindamycin resistance has not been reported yet. Gentamicin resistance was observed in two cases (MIC = 32 mg/L) in Turkey (Ortatatli et al, 2012). All Hungarian strains proved to be susceptible to rifampicin, vancomycin, clindamycin, and gentamicin as well.…”

Section: Discussionmentioning

confidence: 99%

“…The extremely resistant spore is able to survive in the soil for decades (Fasanella et al, 2010). Bacillus anthracis is susceptible to most antibiotics used in therapy (Lightfoot et al, 1990;Doğanay and Aydin, 1991;Odendaal et al, 1991;Cavallo et al, 2002;Coker et al, 2002;Mohammed et al, 2002;Turnbull et al, 2004;Luna et al, 2007;Caplan et al, 2009;Habrun et al, 2011;Ortatatli et al, 2012;Quinn et al, 2011). The main recommended antibiotics to treat human anthrax cases are ciprofloxacin and doxycycline, apart from penicillin (WHO, 2008).…”

mentioning

confidence: 99%

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Antimicrobial susceptibility of Bacillus anthracis strains from Hungary

Kreizinger

Sulyok

Makrai

et al. 2016

Acta Veterinaria Hungarica

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The susceptibility of 29 Bacillus anthracis strains, collected in Hungary between 1933 and 2014, was tested to 10 antibiotics with commercially available minimum inhibitory concentration (MIC) test strips. All strains were susceptible to amoxicillin, ciprofloxacin, clindamycin, doxycycline, gentamicin, penicillin, rifampicin, and vancomycin. Intermediate susceptibility to erythromycin and cefotaxime was detected in 17.2% (5/29) and 58.6% (17/29) of the strains, respectively. Correlations were not observed between the isolation date, location, host species, genotype, and antibiotic susceptibility profile of strains.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Antimicrobial susceptibility of Bacillus anthracis strains from Hungary

Kreizinger

Sulyok

Makrai

et al. 2016

Acta Veterinaria Hungarica

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Resistance in Aerobic Gram-Positive Bacilli

Weber¹,

Miller²,

Rutala³

2017

Antimicrobial Drug Resistance

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Molecular epidemiology of the Bacillus anthracis isolates collected throughout Turkey from 1983 to 2011

Durmaz

Doğanay

Şahin

et al. 2012

Eur J Clin Microbiol Infect Dis

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The main perspective of this study was to determine cross-transmissions amongst anthrax cases and provide detailed information regarding the genotypes of Bacillus anthracis isolates circulating in Turkey. A total of 251 B. anthracis isolates were obtained from human (93 isolates), animal (155 isolates), and environmental (three isolates) samples in various provinces of Turkey. All isolates were susceptible to quinolones, vancomycin, tigecycline, and linezolid, but not to ceftriaxone. Excluding human isolates, one of the animal isolates was found to be resistant to penicillin, erythromycin, and doxycycline. Multiple-locus variable-number tandem repeats analysis including 8 loci (MLVA8) revealed 12 genotypes, in which genotype 43 was observed at the highest frequency (41.8 %), followed by genotype 35 (25.5 %) and genotype 27 (10.4 %). Major subtype A3.a was the predominant cluster, including 86.8 % of the isolates. The MLVA25 analysis for the 251 isolates yielded 62 different genotypes, 33 of which had only one isolate, while the remaining 29 genotypes had 2 to 43 isolates, with a total of 218 isolates (86.9 %). These findings indicate very high cross-transmission rates within anthrax cases in Turkey. The genotypes diagnosed in Turkey are populated in the A major cluster. Penicillin prescribed as the first-choice antibiotic for the treatment of anthrax is still effective.

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Antimicrobial susceptibility and molecular subtyping of 55 Turkish Bacillus anthracis strains using 25-loci multiple-locus VNTR analysis

Cited by 21 publications

References 33 publications

Antimicrobial susceptibility of Bacillus anthracis strains from Hungary

Antimicrobial susceptibility of Bacillus anthracis strains from Hungary

Resistance in Aerobic Gram-Positive Bacilli

Molecular epidemiology of the Bacillus anthracis isolates collected throughout Turkey from 1983 to 2011

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