Antimicrobial Silk Fibroin Hydrogel Instantaneously Induced by Cationic 
 Surfactant

Lu, Shenzhou; Xing, Tieling; Sun, Shan; Zhang, Fang; Zhang, Shanshan

doi:10.3923/biotech.2013.128.134

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…SFT in DI water was 72.5 mN/m, aligned with previous studies. 36,47,48 The HSF sols exhibited significantly higher SFT than those of the SF sol at different concentrations (Figure 7C). Moreover, the liquid contact angles of the HSF sol on a hydrophobic PDMS membrane were also significantly larger than those of SF sol at the concentration of 0 to 0.8% (w/v).…”

Section: Resultsmentioning

confidence: 98%

“…A DataPhysics DCAT-21 surface tension instrument was used to characterize HSF and SF sol via the Wilhemy plate method for surface tension. ,, The HSF and SF sol were poured into a circular thermostated dish (60 cm 2 , 25 °C ± 0.5 °C) separately for surface tension measurements. The results were determined when the standard deviation of the SFT was less than 0.03 mN m –1 in the last 50 cycled measurements and the accuracy was 0.001 mN m –1 The concentrations of HSF and SF sol were 0.25, 0.5, and 0.75% (w/v).…”

Section: Methodsmentioning

confidence: 99%

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Self-Assembling Silk-Based Nanofibers with Hierarchical Structures

Yin

Zheng

et al. 2017

ACS Biomater. Sci. Eng.

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Self-assembling fibrous supramolecular assemblies with sophisticated hierarchical structures at the mesoscale are of interest from both fundamental and applied engineering. In this paper, the relatively hydrophilic domains of silk fibroin (HSF) were extracted and used in studies of self-assembly. The HSF fraction spontaneously self-assembled into nanofibers, 10 to 100 μm long and 50 to 250 nm in diameter, within 2 to 8 h in aqueous conditions. Interestingly, these HSF nanofibers consisted of dozens of nanofibrils arranged in a parallel organization with assembled diameters of ∼30 nm, similar to the sophisticated hierarchical structure observed in native silk fibers. Dynamic morphology and conformation studies were carried out to determine the mechanisms underlying the HSF self-assembly process at both the nanoscale and mesoscale. The HSF self-assembled into nanofibers in a bottom-to-up manner, from “sticky” colloid particles to cylindrical globules, to form nanofibrous networks. Because of the enhanced HSF self-assembling kinetics and the hierarchical structure of HSF nanofibers, this hydrophilicity-driven approach provides further insight into silk fibroin (SF) self-assembly in vivo and also offers new tools for the recapitulation of high-performance materials for engineering applications.

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Section: Resultsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Self-Assembling Silk-Based Nanofibers with Hierarchical Structures

Yin

Zheng

et al. 2017

ACS Biomater. Sci. Eng.

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“…Sun et al prepared fibroin hydrogels using a cationic surfactant, Dodecyltrimethylammonium bromide (DTAB), as a gelation agent and studied the antimicrobial activity of the hydrogels. 94 In the absence of surfactant, gelation of fibroin solution took place over 10 days at 37 °C. Upon surfactant addition, the gelation took place within an hour.…”

Section: Self-assembled Sf Hydrogelsmentioning

confidence: 99%

Self-assembled silk fibroin hydrogels: from preparation to biomedical applications

2022

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“…Regenerated Silk fibroin (RSF) derived from Bombyx mori , is a suitable hydrogel candidate material for bioapplications due to its biocompatibility, biodegradation and easy processability. 3,4 RSF hydrogels could be prepared by inducing β-sheet formation in RSF aqueous solutions via several triggers such as temperature, 5 pH, 6 metal ions, 7 sonication, 8 vortexing 9 surfactants 10,11 or by chemical crosslinking of RSF. 12 However, the RSF hydrogels generally exhibit weak mechanical properties and lack of functionality, which limits their use in various biomedical applications.…”

Section: Introductionmentioning

confidence: 99%