Highly stretchable, self-healing and conductive silk fibroin-based double network gels <i>via</i> a sonication-induced and self-emulsifying green procedure

Fang, Tao; Zhu, Jingxin; Xu, Sheng; Jia, Lan; Ma, Yanlong

doi:10.1039/d2ra00954d

Cited by 3 publications

(5 citation statements)

References 38 publications

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“…The hydrophobic part of the polymer chain forms dynamic HA with the surfactant micelles, which serves as the physical cross-linking center to further improve the mechanical properties of the hydrogel. [42,43] It can be seen from Figure 3g-i that after the introduction of micelles, the tensile strain of the hydrogel was significantly increased, and the fracture force value was increased to 98 kPa, and the corresponding toughness was also significantly improved. The experimental results showed that the introduction of micelles was conductive to the mechanical properties of the hydrogel.…”

Section: Mechanical Properties Characterizationmentioning

confidence: 99%

Flexible MXene‐Based Hydrogel Enables Wearable Human–Computer Interaction for Intelligent Underwater Communication and Sensing Rescue

Zang

Chen

et al. 2023

Adv Funct Materials

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Conductive hydrogels have recently attracted extensive attention in the field of smart wearable electronics. Despite the current versatility of conductive hydrogels, the balance between mechanical properties (tensile properties, strength, and toughness) and electrical properties (electrical conductivity, sensitivity, and stability) still faces great challenges. Herein, a simplified method for constructing hydrophobic association hydrogels with excellent mechanical and electrical properties is proposed. The prepared conductive hydrogels exhibit high tensile properties (≈1224%), high linearity in the whole‐strain–range (R2 = 0.999), and a wide strain sensing range (2700%). The conductive hydrogel can realize more than 1000 cycles of sensing under 500% tensile strain. As an application demonstration, an underwater communication device is assembled in combination with polydimethylsiloxane/Triton X‐100 film coating, which successfully transmits underwater signals and provides warning of potential hazards. This study provides a new research method for developing underwater equipment with excellent mechanical properties and sensing properties.

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Section: Mechanical Properties Characterizationmentioning

confidence: 99%

Flexible MXene‐Based Hydrogel Enables Wearable Human–Computer Interaction for Intelligent Underwater Communication and Sensing Rescue

Zang

Chen

et al. 2023

Adv Funct Materials

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“…[41,42] However, silk fibroin protein-based hydrogels are weak owing to the simple network structure formed by physical or chemical cross-linking, so it is important to improve the mechanical properties of hydrogels to meet actual application requirements. [43] Meanwhile, after a particular treatment like organic solvents, the mechanical characteristics of the silk fibroin hydrogels were improved, which however reduced the biocompatibility to some extent. [44] Many researchers attempted to fabricate silk fibroin MNs for drug delivery systems, but they are also unsuitable for long-term drug release due to poor mechanical properties and dissolvable ability resulting in burst drug release.…”

Section: Introductionmentioning

confidence: 99%

Human Albumin‐Based Hydrogels for Their Potential Xeno‐Free Microneedle Applications

Rong

Mehwish

Niu

et al. 2023

Macromolecular Bioscience

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Nowadays, hydrogels-based microneedles (MNs) have attracted a great interest owing to their outstanding qualities for biomedical applications. For the fabrication of hydrogels-based microneedles as tissue engineering scaffolds and drug delivery carriers, various biomaterials have been tested. They are required to feature tunable physiochemical properties, biodegradability, biocompatibility, nonimmunogenicity, high drug loading capacity, and sustained drug release. Among biomaterials, human proteins are the most ideal biomaterials for fabrication of hydrogels-based MNs; however, they are mechanically weak and poorly processible. To the best of the knowledge, there are no reports of xeno-free human protein-based MNs so far. Here, human albumin-based hydrogels and microneedles for tissue engineering and drug delivery by using relatively new processible human serum albumin methacryloyl (HSAMA) are engineered. The resultant HSAMA hydrogels display tunable mechanical properties, biodegradability, and good biocompatibility. Moreover, the xeno-free HSAMA microneedles display a sustained drug release profile and significant mechanical strength to penetrate the model skin. In vitro, they also show good biocompatibility and anticancer efficacy. Sustainable processible human albumin-based biomaterials may be employed as a xeno-free platform in vivo for tissue engineering and drug delivery in clinical trials in the future.

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“…It was shown that SF prevents the coalescence of hydrophobic droplets in aqueous solutions and facilitates the formation of a stable oil-in-water emulsion. − Wen et al used SF as a self-emulsifier to form an oil-in-water (o/w) emulsion by emulsifying 1-butanol in an aqueous SF solution without the need for any other surface-active agent . Emulsifying performance of SF in combination with a cosurfactant was also used to prepare a double-network hydrogel consisting of a physically cross-linked SF hydrogel and hydrophobically modified polyacrylamide as the first and second networks, respectively …”

Section: Introductionmentioning

confidence: 99%

“…25 Emulsifying performance of SF in combination with a cosurfactant was also used to prepare a double-network hydrogel consisting of a physically cross-linked SF hydrogel and hydrophobically modified polyacrylamide as the first and second networks, respectively. 29 Herein, we present a versatile strategy to prepare OHGs consisting of an SF hydrogel as the continuous phase and microinclusions based on poly(n-octadecyl acrylate) (PC18A), which is a semicrystalline polymer with a melting temperature of around 50 °C (Scheme 1). Recent works from our group show that the hydrogels and polymer blends based on PC18A exhibit superior properties including switchable mechanics and viscoelasticity, shape-memory, and self-healing functions.…”

Section: Introductionmentioning

confidence: 99%

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Silk Fibroin-Based Shape-Memory Organohydrogels with Semicrystalline Microinclusions

Oral

Yetiskin

Cil

et al. 2023

ACS Appl. Bio Mater.

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Inspired by nature, we designed organohydrogels (OHGs) consisting of a silk fibroin (SF) hydrogel as the continuous phase and the hydrophobic microinclusions based on semicrystalline poly(n-octadecyl acrylate) (PC18A) as the dispersed phase. SF acts as a self-emulsifier to obtain oil-in-water emulsions, and hence, it is a versatile and green alternative to chemical emulsifiers. We first prepared a stable oil-in-water emulsion without an external emulsifier by dispersing the noctadecyl acrylate (C18A) monomer in an aqueous SF solution.To stabilize the emulsions for longer times, gelation in the continuous SF phase was induced by the addition of ethanol, which is known to trigger the conformational transition in SF from random coil to β-sheet structures. In the second step, in situ polymerization of C18A droplets in the emulsion system was conducted under UV light in the presence of a photoinitiator to obtain high-strength OHGs with shape-memory function, and good cytocompatibility. The incorporation of hydrophilic N,Ndimethylacrylamide and noncrystallizable hydrophobic lauryl methacrylate units in the hydrogel and organogel phases of OHGs, respectively, further improved their mechanical and shape-memory properties. The shape-memory OHGs presented here exhibit switchable viscoelasticity and mechanics, a high Young's modulus (up to 4.3 ± 0.1 MPa), compressive strength (up to 2.5 ± 0.1 MPa), and toughness (up to 0.68 MPa).

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Highly stretchable, self-healing and conductive silk fibroin-based double network gels via a sonication-induced and self-emulsifying green procedure

Abstract: Silk fibroin-based double network gels, which were synthesized by the free radical polymerization via sonication-induced and self-emulsifying green procedure, exhibited highly stretchable, good self-healing and satisfactory conductive.

Cited by 3 publications

References 38 publications

Flexible MXene‐Based Hydrogel Enables Wearable Human–Computer Interaction for Intelligent Underwater Communication and Sensing Rescue

Flexible MXene‐Based Hydrogel Enables Wearable Human–Computer Interaction for Intelligent Underwater Communication and Sensing Rescue

Human Albumin‐Based Hydrogels for Their Potential Xeno‐Free Microneedle Applications

Silk Fibroin-Based Shape-Memory Organohydrogels with Semicrystalline Microinclusions

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