Antimicrobial-Resistant Bacteremia in the Elderly: Risk of Previous Hospitalization

Su, Yung-Cheng; Kung, Lu-Chih; Lee, Chao-Hsiung; Chang, Wen-Han; Hung, Chung‐Lieh; Tsao, Chih-Chen; Huang, Ming-Yuan

doi:10.1016/j.ijge.2016.09.002

Cited by 3 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The elderly population is highly relevant to the study in relation to AMR as it is a high antibiotic-exposure population [ 12 , 13 , 14 ]. This population furthermore has a high rate of hospital admissions and residency at long term care facilities, which both are risk environments for colonization with antimicrobial resistant bacteria and antibiotic treatment [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Prior Antibiotic Use Increases Risk of Urinary Tract Infections Caused by Resistant Escherichia coli among Elderly in Primary Care: A Case-Control Study

et al. 2022

View full text Add to dashboard Cite

We investigated whether prior use of antibiotics affects the risk of mecillinam/trimethoprim/nitrofurantoin/multi-resistant Escherichia coli urinary tract infection (UTI) among elderly patients in general practice. Data on urine culture came from urine samples performed in general practice and sent to hospitals in the Capital Region of Denmark, and prescription data came from a nationwide prescription database. The study population consisted of patients with UTI episodes (n = 41,027) caused by E. coli that received a concurrent antibiotic prescription against UTI from 2012 to 2017. We used a case-control design. Cases were UTI episodes caused by mecillinam, trimethoprim, nitrofurantoin or multi-resistant E. coli and controls were UTI episodes caused by E. coli not displaying the respective resistance pattern. We analyzed whether exposure to antibiotics in a period of 8–90 days prior to the UTI episode affected the risk of antibiotic resistant uropathogenic E coli. The analyses were adjusted for age, sex, hospital admission and nursing home status. The odds of resistance to all of the four antibiotics increased significantly after exposure to antibiotics within 90 days prior to the UTI episode. In general, mecillinam showed the lowest increase in the odds for selection of resistance. The results indicate that mecillinam is a favorable antibiotic choice in terms of selection of resistance.

show abstract

Section: Introductionmentioning

confidence: 99%

Prior Antibiotic Use Increases Risk of Urinary Tract Infections Caused by Resistant Escherichia coli among Elderly in Primary Care: A Case-Control Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…reported that elderly patients with a history of hospitalization were more than three times as likely to be infected by ESBLproducing E. coli or K. pneumoniae bacteremia even though they had been discharged more than 360 days ago. 39 The use of urinary catheters is cited as one of the most common sources of infection and medium for bacterial colonization. Utilization of such medical devices is often associated with a history of hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and mortality outcomes of extended-spectrum beta-lactamase producing Escherichia coli bacteremia: A retrospective cohort study from two Indonesian referral hospitals

Siregar

Nelwan

Eppy³

et al. 2022

F1000Res

View full text Add to dashboard Cite

Background: Bacteremia caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) can lead to bloodstream infection and subsequent sepsis which increases morbidity and mortality. Evaluation of risk factors of infection by ESBL-producing E. coli is important as it can decrease inappropriate antibiotic use and mortality rates. This study aimed to identify the risk factors and mortality of bacteremia caused by ESBL-producing E. coli. Methods: This retrospective cohort study included inpatients with confirmed E. coli blood culture examinations from two referral hospitals in Jakarta, Indonesia. Data suspected as risk factors for ESBL-producing E. coli bacteremia (utilization of medical devices, age, Charlson Comorbidity Index, history of hospitalization, and history of antibiotic therapy) were collected for analysis. Clinical profiles and independent risk factors of ESBL-producing E. coli bacteremia associated mortality were also evaluated. Results: A total of 116 subjects were analyzed with 81% aged ≥18 years old. The most common source of infection was the gastrointestinal and intra-abdominal tracts. Malignancy as comorbidity was present in 46.6% subjects. Significant risk factors for developing ESBL-producing E. coli bacteremia were history of antibiotic therapy and utilization of medical devices. The proportion of mortality in ESBL-producing E. coli bacteremia was 55.7% with age and sepsis as its independent risk factors. Conclusions: History of antibiotic therapy and utilization of medical devices were significant risk factors for ESBL-producing E. coli bacteremia. The proportion of mortality in ESBL-producing E. coli bacteremia patients was 55.7% with its independent risk factors being age and sepsis.

show abstract

“…Las ß-lactamasas de espectro extendido (BLEE) son un conjunto de enzimas que descomponen y destruyen la mayoría de antibióticos. Estas enzimas son procedentes de bacilos gram negativas con actividad de hidrolizar a un grupo de antimicrobianos que en su estructura tengan inmerso el anillo β-lactámico (24,25). Se clasifican según Ambler en cuatro clases (A, B, C y D) característico por su homología de las proteínas y no en las fenotípicas.…”

Section: │ 17unclassified

Infecciones Urinarias en pacientes geriátricos por presencia de Escherichia coli y Klebsiella spp productoras de betalactamasas de espectro extendido

et al. 2020

View full text Add to dashboard Cite

Uno de los problemas de salud que más afecta a la población es la infección urinaria, siendo los ancianos la población más vulnerable debido a que su sistema inmunitario se encuentra debilitado por el envejecimiento. Este trabajo tuvo como finalidad establecer la presencia de Escherichia coli y Klebsiella spp productoras de betalactamasas de espectro extendido causantes de infecciones urinarias en pacientes geriátricos del Cantón Machala, Ecuador. Mediante la recolección de 200 muestras de orina, durante el lapso enero-marzo 2019, de los pacientes en ayunas y en recipientes estériles determinando en los análisis microbiológicos urocultivos positivos. Los resultados demuestran que el bacilo E. coli es el agente primordial para tal infección con un 71,5 %, seguido por Klebsiella spp con un 28,5 %. Asimismo, el grupo más susceptible a tal contagio resultó el grupo de mujeres ancianas por factores de su anatomía y fisiología deteriorada por la edad y al mal uso de antibióticos o suspensión del tratamiento terapéutico, generando resistencia bacteriana y dando como resultado que esto se agrave y se tienda a usar antibióticos de amplio espectro. Se recomiendan buenas prácticas de higiene en los genitales en las personas de tercera edad y el uso correcto del antibiograma por parte del personal de salud, para minimizar la presencia de estos patógenos bacterianos.

show abstract

Antimicrobial-Resistant Bacteremia in the Elderly: Risk of Previous Hospitalization

Cited by 3 publications

References 19 publications

Prior Antibiotic Use Increases Risk of Urinary Tract Infections Caused by Resistant Escherichia coli among Elderly in Primary Care: A Case-Control Study

Prior Antibiotic Use Increases Risk of Urinary Tract Infections Caused by Resistant Escherichia coli among Elderly in Primary Care: A Case-Control Study

Risk factors and mortality outcomes of extended-spectrum beta-lactamase producing Escherichia coli bacteremia: A retrospective cohort study from two Indonesian referral hospitals

Infecciones Urinarias en pacientes geriátricos por presencia de Escherichia coli y Klebsiella spp productoras de betalactamasas de espectro extendido

Contact Info

Product

Resources

About