Antimicrobial Resistance to Linezolid

Abstract

Acquired resistance to linezolid, the first approved oxazolidinone, has been selected in laboratory experiments and has been observed in clinical isolates of gram-positive cocci. This resistance has typically been associated with single-nucleotide changes in varying numbers of copies of the genes encoding 23S ribosomal RNA. In the current environment of increasingly prevalent resistance to standard antibiotics, linezolid is an important drug because of its activity against a number of clinically significant gram-positive cocci, including multidrug-resistant staphylococci and enterococci. Although resistance to linezolid remains uncommon, the development of resistance by clinical isolates should prompt increased attention to susceptibility testing for this agent and should be taken into account in consideration of the therapeutic use of this drug.

Determinação da resistência antimicrobiana associada em isolados clínicos de Staphylococcus aureus e Pseudomonas aeruginosa em um hospital público de Goiânia, Estado de Goiás

“…A ocorrência da resistência à linezolida em estabelecimentos clínicos tem sido considerada um fenômeno raro 13 , sendo mais relatada em pacientes debilitados sob longa terapia com este agente e em uso de dispositivos infectados não removidos 18 . Apesar da menor freqüência de resistência de Staphylococcus aureus à linezolida, o achado de resistência associada a este antimicrobiano é preocupante, visto que esta droga tem sido considerada uma das últimas opções terapêuticas para infecções graves causadas por isolados de ORSA, frequentemente multirresistentes 7 .…”

In-vitro antimicrobial activity of marine actinobacteria against multidrug resistance Staphylococcus aureus

“…Morphological characteristics Actinobacteria isolate were inoculated in seven different international streptomyces project (ISP) mediums (ISP 1 to ISP 7) and incubated for 7 days at room temperature. The colonies were observed under a high power magnifying lens and colony morphology was noted with respect to aerial mycelium color, nature of colony and reverse side color.…”

“…Due to the development of drug resistance in S. aureus, treatment of this bacterial infection has become a serious problem [5] . Recently, new antimicrobial agents like daptomycin, linezolid and streptogramin combination (quinupristin/dalfopristin) are useful to treat MRSA [6,7] . However, due to certain defects and escalation of drug resistance it emphasizes the requirement of advance antimicrobial agents having potential activity towards Gram positive bacteria [8] .…”

Synthesis and Antibacterial Activity of Novel 2-Oxo-pyrrolidinyl Oxazolidinones

“…[12][13][14] The most common mechanism of linezolid resistance is point mutations in the 23S rRNA peptidyl transferase region, [15][16][17][18] and recently a new resistance mechanism mediated by cfr gene encoding methyltransferase has been reported. 19,20 Thus, there is a significant need for the development of new oxazolidinone series with an improved potency and spectrum of antibacterial activity.…”